影响牙齿漂白治疗效果因素的研究进展
Research Progress of Factors Influencing the Effect of Teeth Bleaching Treatment
DOI: 10.12677/acm.2025.152559, PDF,    科研立项经费支持
作者: 朱灵珊, 徐镔亭*：重庆医科大学附属口腔医院口腔修复科，重庆；口腔疾病与生物医学重庆市重点实验室，重庆；重庆市高校市级口腔生物医学工程重点实验室，重庆
关键词: 变色牙；漂白治疗；漂白剂；影响因素；Tooth Discoloration； Bleaching Treatment； Bleaching Agents； Influencing Factor
摘要: 着色牙是常见的口腔疾病，根据其病因可以分为外源性着色牙和内源性着色牙两类。随着人们生活水平和经济水平的提高，牙齿变色与美观问题引起越来越多患者的关注，而漂白治疗，作为一种微创性高，对牙齿硬组织损伤较小的治疗方式被越来越多地应用于变色牙的治疗。漂白治疗已经被大量的研究证实其有效性，但漂白治疗的效果受多种因素的影响，本文将就影响漂白治疗效果的因素进行综述。
Abstract: Discolored teeth are common oral diseases, which can be divided into exogenous and endogenous discolored teeth according to their etiology. With the improvement of people’s living standards and economic level, the discoloration and aesthetic problems of teeth have attracted more and more patients’ attention. Bleaching treatment, as a minimally invasive treatment with less damage to the hard tissue of teeth, has been more and more applied in the treatment of discoloration of teeth. Bleaching treatment has been proved effective by a large number of studies, but the effect of bleaching treatment is affected by many factors. This paper reviews the factors influencing the therapeutic effect of tooth bleaching.
文章引用：朱灵珊, 徐镔亭. 影响牙齿漂白治疗效果因素的研究进展[J]. 临床医学进展, 2025, 15(2): 1976-1983. https://doi.org/10.12677/acm.2025.152559

参考文献

[1] Butera, A., Maiorani, C., Rederiene, G., Checchi, S. and Nardi, G.M. (2024) Evaluation of the Effectiveness of Different Types of Professional Tooth Whitening: A Systematic Review. Bioengineering, 11, Article No. 1178. [Google Scholar] [CrossRef] [PubMed]
[2] Nathoo, S.A. (1997) The Chemistry and Mechanisms of Extrinsic and Intrinsic Discoloration. The Journal of the American Dental Association, 128, 6S-10S. [Google Scholar] [CrossRef] [PubMed]
[3] 黄茜, 李文妙, 邢莉, 文小俊. 微研磨联合居家漂白治疗氟斑牙的疗效观察[J]. 中国现代医生, 2021, 59(31): 84-87.
[4] Bloomquist, R.F., Sword, R.J., Londono, J. and Haywood, V.B. (2021) Bleaching: The Initial Treatment Consideration for Tetracycline-Stained Teeth. British Dental Journal, 230, 807-812. [Google Scholar] [CrossRef] [PubMed]
[5] 徐英新. Beyond冷光美白疗效的患者满意度调查[J]. 口腔医学研究, 2016, 32(1): 67-70.
[6] Leonard, R.H., Haywood, V.B., Caplan, D.J. and Tart, N.D. (2003) Nightguard Vital Bleaching of Tetracycline-Stained Teeth: 90 Months Post Treatment. Journal of Esthetic and Restorative Dentistry, 15, 142-153. [Google Scholar] [CrossRef] [PubMed]
[7] Alkahtani, R., Stone, S., German, M. and Waterhouse, P. (2020) A Review on Dental Whitening. Journal of Dentistry, 100, Article ID: 103423. [Google Scholar] [CrossRef] [PubMed]
[8] Takamizawa, T., Aoki, R., Saegusa, M., Hirokane, E., Shoji, M., Yokoyama, M., et al. (2023) Whitening Efficacy and Tooth Sensitivity in a Combined In-Office and At-Home Whitening Protocol: A Randomized Controlled Clinical Trial. Journal of Esthetic and Restorative Dentistry, 35, 821-833. [Google Scholar] [CrossRef] [PubMed]
[9] Donassollo, S.H., Donassollo, T.A., Coser, S., Wilde, S., Uehara, J.L.S., Chisini, L.A., et al. (2021) Triple-Blinded Randomized Clinical Trial Comparing Efficacy and Tooth Sensitivity of In-Office and At-Home Bleaching Techniques. Journal of Applied Oral Science, 29, e20200794. [Google Scholar] [CrossRef] [PubMed]
[10] Kothari, S., Jum’ah, A.A., Gray, A.R., M. Lyons, K., Yap, M. and Brunton, P.A. (2020) A Randomized Clinical Trial Investigating Three Vital Tooth Bleaching Protocols and Associated Efficacy, Effectiveness and Participants’ Satisfaction. Journal of Dentistry, 95, Article ID: 103322. [Google Scholar] [CrossRef] [PubMed]
[11] Naidu, A.S., Bennani, V., Brunton, J.M.A.P. and Brunton, P. (2020) Over-the-Counter Tooth Whitening Agents: A Review of Literature. Brazilian Dental Journal, 31, 221-235. [Google Scholar] [CrossRef] [PubMed]
[12] Deng, S., Zhang, Y., Qiao, Z., Wang, K., Ye, L., Xu, Y., et al. (2023) Hierarchically Designed Biodegradable Polylactide Particles with Unprecedented Piezocatalytic Activity and Biosafety for Tooth Whitening. Biomacromolecules, 24, 797-806. [Google Scholar] [CrossRef] [PubMed]
[13] Patil, P., Ankola, A., Hebbal, M. and Patil, A. (2014) Comparison of Effectiveness of Abrasive and Enzymatic Action of Whitening Toothpastes in Removal of Extrinsic Stains—A Clinical Trial. International Journal of Dental Hygiene, 13, 25-29. [Google Scholar] [CrossRef] [PubMed]
[14] de Oliveira, M.N., Vidigal, M.T.C., Vieira, W., Lins-Candeiro, C.L., Oliveira, L.M., Nascimento, G.G., et al. (2024) Assessment of Color Changes and Adverse Effects of Over-the-Counter Bleaching Protocols: A Systematic Review and Network Meta-Analysis. Clinical Oral Investigations, 28, Article No. 189. [Google Scholar] [CrossRef] [PubMed]
[15] Müller-Heupt, L.K., Wiesmann-Imilowski, N., Kaya, S., Schumann, S., Steiger, M., Bjelopavlovic, M., et al. (2023) Effectiveness and Safety of Over-the-Counter Tooth-Whitening Agents Compared to Hydrogen Peroxide in Vitro. International Journal of Molecular Sciences, 24, Article No. 1956. [Google Scholar] [CrossRef] [PubMed]
[16] Barbosa, L.M.M., Amâncio Filha, M.B.G., Leite, J.V.C., Santos, J.V.d.N., De Medeiros, J.M., De Oliveira, I.L.M., et al. (2024) Over-the-Counter Products in Tooth Bleaching: A Scoping Review. Journal of Dentistry, 145, Article ID: 104989. [Google Scholar] [CrossRef] [PubMed]
[17] Sutil, E., da Silva, K.L., Terra, R.M.O., Burey, A., Rezende, M., Reis, A., et al. (2020) Effectiveness and Adverse Effects of At‐Home Dental Bleaching with 37% versus 10% Carbamide Peroxide: A Randomized, Blind Clinical Trial. Journal of Esthetic and Restorative Dentistry, 34, 313-321. [Google Scholar] [CrossRef] [PubMed]
[18] Wijetunga, C.L., Otsuki, M., Abdou, A., Luong, M.N., Qi, F. and Tagami, J. (2021) The Effect of In-Office Bleaching Materials with Different pH on the Surface Topography of Bovine Enamel. Dental Materials Journal, 40, 1345-1351. [Google Scholar] [CrossRef] [PubMed]
[19] Ito, Y., Otsuki, M. and Tagami, J. (2019) Effect of pH Conditioners on Tooth Bleaching. Clinical and Experimental Dental Research, 5, 212-218. [Google Scholar] [CrossRef] [PubMed]
[20] Xu, B., Li, Q. and Wang, Y. (2011) Effects of pH Values of Hydrogen Peroxide Bleaching Agents on Enamel Surface Properties. Operative Dentistry, 36, 554-562. [Google Scholar] [CrossRef] [PubMed]
[21] Priyadarsini, S., Mukherjee, S. and Mishra, M. (2018) Nanoparticles Used in Dentistry: A Review. Journal of Oral Biology and Craniofacial Research, 8, 58-67. [Google Scholar] [CrossRef] [PubMed]
[22] Kim, D., Bae, J., Heo, J.H., Park, C.H., Kim, E.B. and Lee, J.H. (2022) Nanoparticles as Next-Generation Tooth-Whitening Agents: Progress and Perspectives. ACS Nano, 16, 10042-10065. [Google Scholar] [CrossRef] [PubMed]
[23] Fu, P.P., Xia, Q., Hwang, H., Ray, P.C. and Yu, H. (2014) Mechanisms of Nanotoxicity: Generation of Reactive Oxygen Species. Journal of Food and Drug Analysis, 22, 64-75. [Google Scholar] [CrossRef] [PubMed]
[24] Cheng, Y., Zhong, B., Su, C., Lu, Z. and Yu, H. (2024) Enhanced Tooth Bleaching with a Hydrogen Peroxide/Titanium Dioxide Gel. BMC Oral Health, 24, Article No. 923. [Google Scholar] [CrossRef] [PubMed]
[25] Antunes, E.V.G., Basting, R.T., do Amaral, F.L.B., França, F.M.G., Turssi, C.P., Kantovitz, K.R., et al. (2022) Titanium Dioxide Nanotubes in a Hydrogen Peroxide-Based Bleaching Agent: Physicochemical Properties and Effectiveness of Dental Bleaching under the Influence of a Poliwave Led Light Activation. Clinical Oral Investigations, 27, 1745-1755. [Google Scholar] [CrossRef] [PubMed]
[26] Caneschi, C.d.S., Benetti, F., de Oliveira, L.C.A., Belchior, J.C., Ferreira, R.C., Moreira, A.N., et al. (2023) Bleaching Effectiveness and Cytotoxicity of New Experimental Formulation of Niobium-Based Bleaching Gel. Clinical Oral Investigations, 27, 1613-1621. [Google Scholar] [CrossRef] [PubMed]
[27] Münchow, E.A., Hamann, H.J., Carvajal, M.T., Pinal, R. and Bottino, M.C. (2016) Stain Removal Effect of Novel Papain-and Bromelain-Containing Gels Applied to Enamel. Clinical Oral Investigations, 20, 2315-2320. [Google Scholar] [CrossRef] [PubMed]
[28] Kohli, S., Bhatia, S., Banavar, S.R., Al-Haddad, A., Kandasamy, M., Qasim, S.S.B., et al. (2023) In-Vitro Evaluation of the Effectiveness of Polyphenols Based Strawberry Extracts for Dental Bleaching. Scientific Reports, 13, Article No. 4181. [Google Scholar] [CrossRef] [PubMed]
[29] Gasmi Benahmed, A., Gasmi, A., Menzel, A., Hrynovets, I., Chirumbolo, S., Shanaida, M., et al. (2022) A Review on Natural Teeth Whitening. Journal of Oral Biosciences, 64, 49-58. [Google Scholar] [CrossRef] [PubMed]
[30] Gallinari, M.d.O., Cintra, L.T.A., Souza, M.B.d.A., Barboza, A.C.S., Esteves, L.M.B., Fagundes, T.C., et al. (2019) Clinical Analysis of Color Change and Tooth Sensitivity to Violet LED during Bleaching Treatment: A Case Series with Split-Mouth Design. Photodiagnosis and Photodynamic Therapy, 27, 59-65. [Google Scholar] [CrossRef] [PubMed]
[31] Costa, J.L.d.S.G., Nogueira, B.R., Batista de Oliveira Junior, O. and Pretel, H. (2022) The Influence of Hydrogen Peroxide Concentration on the Chemical Kinetics of Photo-Accelerated Tooth Whitening. Photodiagnosis and Photodynamic Therapy, 40, Article ID: 103175. [Google Scholar] [CrossRef] [PubMed]
[32] Manzoli, T.M., Costa, J.L.d.S.G., Besegato, J.F., Gelio, M.B., Galvani, L.D., Bordini, E.A.F., et al. (2022) Violet LED Associated with High Concentration Hydrogen Peroxide: Effects on Bleaching Efficacy, pH, and Temperature. Photodiagnosis and Photodynamic Therapy, 40, Article ID: 103133. [Google Scholar] [CrossRef] [PubMed]
[33] 孙皎. 活髓牙漂白材料面临的挑战与展望[J]. 口腔材料器械杂志, 2021, 30(1): 1-6.
[34] 赵雅丽, 王植, 高阳, 等. 磷酸钛氧钾激光在牙齿漂白治疗中的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 195-202.
[35] 路秀燕, 龙兴华. 牙釉质车针打磨联合祛氟剂、Beyond冷光美白技术治疗中度氟斑牙患者的疗效评价[J]. 中国医疗美容, 2020, 10(11): 108-112.
[36] Celik, E., Yıldız, G. and Yazkan, B. (2013) Comparison of Enamel Microabrasion with a Combined Approach to the Esthetic Management of Fluorosed Teeth. Operative Dentistry, 38, E134-E143. [Google Scholar] [CrossRef] [PubMed]
[37] Sundfeld, D., Pavani, C., Pini, N., Machado, L., Schott, T. and Sundfeld, R. (2019) Enamel Microabrasion and Dental Bleaching on Teeth Presenting Severe-Pitted Enamel Fluorosis: A Case Report. Operative Dentistry, 44, 566-573. [Google Scholar] [CrossRef] [PubMed]
[38] Bourouni, S., Dritsas, K., Kloukos, D. and Wierichs, R.J. (2021) Efficacy of Resin Infiltration to Mask Post-Orthodontic or Non-Post-Orthodontic White Spot Lesions or Fluorosis—A Systematic Review and Meta-Analysis. Clinical Oral Investigations, 25, 4711-4719. [Google Scholar] [CrossRef] [PubMed]
[39] Raut, A., Mantri, V., Gedam, P. and Phabyani, P. (2020) Conservative Esthetic Management of Severe Dental Fluorosis with In-Office Power Bleaching. Annals of African Medicine, 19, 211-214. [Google Scholar] [CrossRef] [PubMed]
[40] Gugnani, N., Pandit, I.K., Gupta, M., Gugnani, S., Soni, S. and Goyal, V. (2017) Comparative Evaluation of Esthetic Changes in Nonpitted Fluorosis Stains When Treated with Resin Infiltration, In‐Office Bleaching, and Combination Therapies. Journal of Esthetic and Restorative Dentistry, 29, 317-324. [Google Scholar] [CrossRef] [PubMed]
[41] Schoppmeier, C.M., Derman, S.H.M., Noack, M.J. and Wicht, M.J. (2018) Power Bleaching Enhances Resin Infiltration Masking Effect of Dental Fluorosis. A Randomized Clinical Trial. Journal of Dentistry, 79, 77-84. [Google Scholar] [CrossRef] [PubMed]
[42] Krishnakumar, K., Tandale, A., Mehta, V., Khade, S., Talreja, T., Aidasani, G., et al. (2022) Post-Operative Sensitivity and Color Change Due to In-Office Bleaching with the Prior Use of Different Desensitizing Agents: A Systematic Review. Cureus, 14, e24028. [Google Scholar] [CrossRef] [PubMed]
[43] Vochikovski, L., Favoreto, M.W., Rezende, M., Terra, R.M.O., da Silva, K.L., Farago, P.V., et al. (2022) Effect of an Experimental Desensitizing Gel on Bleaching-Induced Tooth Sensitivity after In-Office Bleaching—A Double-Blind, Randomized Controlled Trial. Clinical Oral Investigations, 27, 1567-1576. [Google Scholar] [CrossRef] [PubMed]
[44] Martini, E.C., Favoreto, M.W., Rezende, M., de Geus, J.L., Loguercio, A.D. and Reis, A. (2021) Topical Application of a Desensitizing Agent Containing Potassium Nitrate before Dental Bleaching: A Systematic Review and Meta-Analysis. Clinical Oral Investigations, 25, 4311-4327. [Google Scholar] [CrossRef] [PubMed]
[45] Mohammadipour, H.S., Shokrollahi, P., Gholami, S., Bagheri, H., Namdar, F. and Sekandari, S. (2024) Do Different Tooth Bleaching–Remineralizing Regimens Affect the Bleaching Effectiveness and Enamel Microhardness in Vitro? International Journal of Dentistry, 2024, Article ID: 6893472. [Google Scholar] [CrossRef] [PubMed]
[46] Wang, Y., Gao, J., Jiang, T., Liang, S., Zhou, Y. and Matis, B.A. (2015) Evaluation of the Efficacy of Potassium Nitrate and Sodium Fluoride as Desensitizing Agents during Tooth Bleaching Treatment—A Systematic Review and Meta-analysis. Journal of Dentistry, 43, 913-923. [Google Scholar] [CrossRef] [PubMed]
[47] Sadri, M., Nakhostin, A. and Salamat, F. (2023) Effects of Laser Irradiation and Tooth Mousse on Tooth Hypersensitivity after Office Bleaching: A Non-Randomized Clinical Trial. Dental Research Journal, 20, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[48] Yang, S., Han, A.R., Kim, K. and Kwon, J. (2022) Effects of Incorporating 45S5 Bioactive Glass into 30% Hydrogen Peroxide Solution on Whitening Efficacy and Enamel Surface Properties. Clinical Oral Investigations, 26, 5301-5312. [Google Scholar] [CrossRef] [PubMed]
[49] Martins, B.V., Dias, M.F., de Oliveira Ribeiro, R.A., Leite, M.L.d.A.e.S., Hebling, J. and de Souza Costa, C.A. (2022) Innovative Strategy for In-Office Tooth Bleaching Using Violet LED and Biopolymers as H2O2 Catalysts. Photodiagnosis and Photodynamic Therapy, 38, Article ID: 102886. [Google Scholar] [CrossRef] [PubMed]
[50] Charakorn, P., Cabanilla, L.L., Wagner, W.C., Foong, W., Shaheen, J., Pregitzer, R., et al. (2009) The Effect of Preoperative Ibuprofen on Tooth Sensitivity Caused by In-Office Bleaching. Operative Dentistry, 34, 131-135. [Google Scholar] [CrossRef] [PubMed]
[51] da Costa Poubel, L.A., de Gouvea, C.V.D., Calazans, F.S., Dip, E.C., Alves, W.V., Marins, S.S., et al. (2018) Pre-operative Use of Dexamethasone Does Not Reduce Incidence or Intensity of Bleaching-Induced Tooth Sensitivity. A Triple-Blind, Parallel-Design, Randomized Clinical Trial. Clinical Oral Investigations, 23, 435-444. [Google Scholar] [CrossRef] [PubMed]

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