犬尿氨酸代谢通路与卒中后抑郁的研究进展
Progress in the Study of Canine Uridine Metabolic Pathway and Post-Stroke Depression
DOI: 10.12677/acm.2025.152565, PDF,    科研立项经费支持
作者: 曹欣颖, 李英浩, 赵立波*：重庆医科大学附属永川医院神经内科，重庆；脑血管病研究重庆市重点实验室，重庆
关键词: 卒中后抑郁；犬尿氨酸代谢途径；炎症反应；Post-Stroke Depression； Kynurenine Metabolic Pathway； Inflammatory Reaction
摘要: 卒中后抑郁(post stroke depression, PSD)是脑卒中患者非常常见的并发症，其三大核心症状是：心情低落、兴趣减退及易疲劳，卒中后抑郁可发生在卒中后急性期，中期和恢复期，其发生率均在30%左右。目前卒中后抑郁的发病机制尚不清楚。犬尿氨酸代谢途径(kynurenine pathway, KP)被认为是连接神经系统免疫炎性反应等多个系统与抑郁症的主要途径。本文就犬尿氨酸代谢途径参与卒中后抑郁的病理生理学机制及其调控对抑郁症状的影响的研究做一综述，旨在为进一步研究抑郁的形成机制提供参考。
Abstract: Post stroke depression (PSD) is a very common complication in stroke patients, with three core symptoms: depressed mood, loss of interest and fatigue. PSD can occur in the acute, middle and recovery periods after stroke, with an incidence rate of about 30%. The pathogenesis of post-stroke depression is still unclear. The kynurenine pathway (KP) is thought to be a major pathway linking multiple systems, including the immune-inflammatory response of the nervous system, to depression. In this paper, we present a review on the pathophysiological mechanisms of kynurenine pathway involved in post-stroke depression and its modulation on depressive symptoms, with the aim of providing a reference for further research on the formation mechanisms of depression.
文章引用：曹欣颖, 李英浩, 赵立波. 犬尿氨酸代谢通路与卒中后抑郁的研究进展[J]. 临床医学进展, 2025, 15(2): 2028-2032. https://doi.org/10.12677/acm.2025.152565

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