拔除第三磨牙联合复方氯唑沙宗治疗颞下颌关节紊乱症的研究综述

A Review of the Study on the Treatment of Temporomandibular Joint Disorder by Combining the Extraction of the Third Molar and Compound Chlorzoxazone

摘要: 目的：综述拔除产生咬合干扰的第三磨牙及复方氯唑沙宗治疗颞下颌关节紊乱症的研究进展。方法：通过检索近20年来国内外对于拔除第三磨牙及复方氯唑沙宗治疗颞下颌关节紊乱症的文献，从颞下颌关节紊乱症的临床诊断、分类、病因和上述两种治疗方法的作用机制以及临床治疗效果等现有的研究进行总结。结果：拔除导致咬合紊乱的第三磨牙可以通过消除不良咬合因素达到治疗颞下颌关节紊乱症的目的；复方氯唑沙宗作为一种中枢性骨骼肌松弛剂可以在一定程度上缓解颞下颌关节紊乱症患者的肌肉功能亢进及肌肉疼痛的症状。结论：对于拔除第三磨牙以及复方氯唑沙宗治疗颞下颌关节紊乱症的机制应当进行深入的研究，对于其二者联用的综合疗法应当通过大样本的临床试验证明以及客观的疗效评价，合理把握临床适应证，为临床治疗颞下颌关节紊乱症提供行之有效的治疗策略。

Abstract: Objective: To review the research progress on the treatment of temporomandibular joint disorder by extracting the third molar causing occlusal interference and using the compound chlorzoxazone. Methods: By searching for domestic and international literature on the extraction of the third molar and the treatment of temporomandibular joint disorder with compound chlorzoxazone over the past 20 years, this paper summarizes the existing research on the clinical diagnosis and classification of temporomandibular joint disorder, its causes, the mechanisms of action of the above two treatment methods, and their clinical therapeutic effects. Results: Extracting the third molar that causes occlusal disorder can treat temporomandibular joint disorder by eliminating adverse occlusal factors; compound chlorzoxazone, as a central skeletal muscle relaxant, can alleviate the symptoms of muscle hyperfunction and muscle pain in patients with temporomandibular joint disorder to a certain extent. Conclusion: The mechanisms of extracting the third molar and treating the temporomandibular joint disorder with the compound chlorzoxazone should be further studied. The combined therapy of the two should be proven through large-scale clinical experiments and objective therapeutic evaluations, and the clinical indications should be reasonably grasped to provide effective treatment strategies for the clinical treatment of temporomandibular joint disorder.