IP-10与PWH的相关性研究进展
Research Progress in the Correlation between IP-10 and PWH
DOI: 10.12677/acm.2025.153666, PDF,   
作者: 吕春林：成都中医药大学医学与生命科学学院，四川 成都；赵 川*：遂宁市中心医院感染科，四川 遂宁
关键词: IP-10；HIV；AIDS；IP-10； HIV； AIDS
摘要: 虽然目前公认抗逆转录病毒治疗(antiretroviral therapy, ART)可以延长HIV感染者(People with HIV, PWH)生存时间及改善生活质量，但持续存在的免疫激活将导致HIV相关非AIDS并发症的进一步发生。γ-干扰素诱导蛋10 (interferon gamma-induced protein 10, IP-10)是一种或在免疫系统中发挥着关键作用的炎症趋化因子，目前在国内外的PWH研究中得到广泛关注。
Abstract: It is now well established that antiretroviral therapy (ART) can prolong the survival time and improve the quality of life of people with HIV (PWH), but persistent immune activation remains a significant concern, leading to the further development of HIV-related non-AIDS complications. Interferon gamma-induced protein 10 (IP-10), an inflammatory chemokine that plays a crucial role in the immune system, has garnered considerable attention in both domestic and international research on PWH.
文章引用：吕春林, 赵川. IP-10与PWH的相关性研究进展[J]. 临床医学进展, 2025, 15(3): 691-695. https://doi.org/10.12677/acm.2025.153666

参考文献

[1] Aslan, F., Koroglu, M., Karabay, O., Inci, M. and Altindis, M. (2021) A Predictive Test in the Screening of HIV Positive Cases; Interferon Gamma Inducible Protein 10 (IP-10). Clinical Laboratory, 67. [Google Scholar] [CrossRef] [PubMed]
[2] Chéret, A., Durier, C., Mélard, A., Ploquin, M., Heitzmann, J., Lécuroux, C., et al. (2017) Impact of Early Cart on HIV Blood and Semen Compartments at the Time of Primary Infection. PLOS ONE, 12, e0180191. [Google Scholar] [CrossRef] [PubMed]
[3] Côrtes, F.H., de Paula, H.H.S., Bello, G., Ribeiro-Alves, M., de Azevedo, S.S.D., Caetano, D.G., et al. (2018) Plasmatic Levels of IL-18, IP-10, and Activated CD8+ T Cells Are Potential Biomarkers to Identify HIV-1 Elite Controllers with a True Functional Cure Profile. Frontiers in Immunology, 9, Article 1576. [Google Scholar] [CrossRef] [PubMed]
[4] Eller, M.A., Hong, T., Creegan, M., Nau, M.E., Sanders-Buell, E., Slike, B.M., et al. (2020) Activated PD-1+ CD4+ T Cells Represent a Short-Lived Part of the Viral Reservoir and Predict Poor Immunologic Recovery Upon Initiation of Art. AIDS, 34, 197-202. [Google Scholar] [CrossRef] [PubMed]
[5] Hassan, A.S., Hare, J., Gounder, K., Nazziwa, J., Karlson, S., Olsson, L., et al. (2021) A Stronger Innate Immune Response during Hyperacute Human Immunodeficiency Virus Type 1 (HIV-1) Infection Is Associated with Acute Retroviral Syndrome. Clinical Infectious Diseases, 73, 832-841. [Google Scholar] [CrossRef] [PubMed]
[6] Masson, L., Passmore, J.S., Liebenberg, L.J., Werner, L., Baxter, C., Arnold, K.B., et al. (2015) Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases, 61, 260-269. [Google Scholar] [CrossRef] [PubMed]
[7] Mhandire, K., Mlambo, T., Zijenah, L.S., Duri, K., Mateveke, K., Tshabalala, M., et al. (2017) Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection. The Open AIDS Journal, 11, 24-31. [Google Scholar] [CrossRef] [PubMed]
[8] Pastor, L., Casellas, A., Carrillo, J., Alonso, S., Parker, E., Fuente-Soro, L., et al. (2017) IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV Infection in Resource-Limited Settings. Scientific Reports, 7, Article No. 8104. [Google Scholar] [CrossRef] [PubMed]
[9] Pastor, L., Casellas, A., Rupérez, M., Carrillo, J., Maculuve, S., Jairoce, C., et al. (2017) Interferon-γ-Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings. Clinical Infectious Diseases, 65, 1670-1675. [Google Scholar] [CrossRef] [PubMed]
[10] Pastor, L., Urrea, V., Carrillo, J., Parker, E., Fuente-Soro, L., Jairoce, C., et al. (2018) Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults. Frontiers in Immunology, 8, Article 1925. [Google Scholar] [CrossRef] [PubMed]
[11] Reepalu, A., Arimide, D.A., Balcha, T.T., Björkman, P. and Medstrand, P. (2020) Brief Report: Interferon-γ-Inducible Protein 10—A Potential Marker for Targeted Viral Load Monitoring of Antiretroviral Treatment? JAIDS Journal of Acquired Immune Deficiency Syndromes, 83, 475-478. [Google Scholar] [CrossRef] [PubMed]
[12] Riitho, V., Connon, R., Gwela, A., Namusanje, J., Nhema, R., Siika, A., et al. (2024) Biomarkers of Mortality in Adults and Adolescents with Advanced HIV in Sub-Saharan Africa. Nature Communications, 15, Article No. 5492. [Google Scholar] [CrossRef] [PubMed]
[13] Schindler, S., Netto, E., Deminco, F., Figueiredo, C.A., de Andrade, C.M., Alves, A.R., et al. (2024) Detection of Cytokines in Cervicovaginal Lavage in HIV-Infected Women and Its Association with High-Risk Human Papillomavirus. Frontiers in Immunology, 15, Article 1416204. [Google Scholar] [CrossRef] [PubMed]
[14] Schnittman, S.R., Deitchman, A.N., Beck-Engeser, G., Ahn, H., York, V.A., Hartig, H., et al. (2020) Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus. The Journal of Infectious Diseases, 223, 1621-1630. [Google Scholar] [CrossRef] [PubMed]
[15] Stiksrud, B., Aass, H.C.D., Lorvik, K.B., Ueland, T., Trøseid, M. and Dyrhol-Riise, A.M. (2019) Activated Dendritic Cells and Monocytes in HIV Immunological Nonresponders: HIV-Induced Interferon-Inducible Protein-10 Correlates with Low Future CD4+ Recovery. AIDS, 33, 1117-1129. [Google Scholar] [CrossRef] [PubMed]
[16] Stiksrud, B., Lorvik, K.B., Kvale, D., Mollnes, T.E., Ueland, P.M., Trøseid, M., et al. (2016) Plasma IP-10 Is Increased in Immunological Nonresponders and Associated with Activated Regulatory T Cells and Persisting Low CD4 Counts. JAIDS Journal of Acquired Immune Deficiency Syndromes, 73, 138-148. [Google Scholar] [CrossRef] [PubMed]
[17] Thorman, J., Björkman, P., Marrone, G., Tolera Balcha, T., Tesfaye, F., Abdissa, T., et al. (2021) Interferon-γ-Inducible Protein 10 (IP-10) Kinetics after Antiretroviral Treatment Initiation in Ethiopian Adults with HIV. Microbiology Spectrum, 9, e0181021. [Google Scholar] [CrossRef] [PubMed]
[18] Turk, G., Ghiglione, Y., Hormanstorfer, M., Laufer, N., Coloccini, R., Salido, J., et al. (2018) Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4+ T-Cell Count? Viruses, 10, Article 34. [Google Scholar] [CrossRef] [PubMed]
[19] Wang, Z., Wu, T., Ma, M., Zhang, Z., Fu, Y., Liu, J., et al. (2017) Elevated Interferon-γ-Induced Protein 10 and Its Receptor CXCR3 Impair NK Cell Function during HIV Infection. Journal of Leukocyte Biology, 102, 163-170. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, Z., Yin, X., Ma, M., Ge, H., Lang, B., Sun, H., et al. (2021) IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway. Frontiers in Immunology, 12, Article 656663. [Google Scholar] [CrossRef] [PubMed]
[21] Wu, X., Zhang, L., Yin, L., Fu, Y., Jiang, Y., Ding, H., et al. (2017) Deregulated MicroRNA-21 Expression in Monocytes from HIV-Infected Patients Contributes to Elevated IP-10 Secretion in HIV Infection. Frontiers in Immunology, 8, Article 1122. [Google Scholar] [CrossRef] [PubMed]

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