布比卡因脂质体在膝关节置换术后镇痛中的应用进展

Advances in the Use of Liposomal Bupivacaine in Postoperative Analgesia after Knee Arthroplasty

摘要: 膝关节置换手术产生的创伤刺激常使患者术后承受着中到重度疼痛，这不仅使患者术后体验不佳，疼痛应激还会加重机体的内环境紊乱，对患者的术后康复产生不利的影响。现在多模式镇痛理念越来越多被应用到术后镇痛中，即将多种不同机制的镇痛药物和镇痛方法进行合理有效的结合，发挥最佳的镇痛效应。布比卡因脂质体作为一种具有稳定性和长效性特点的新型缓释局麻药在术后多模式镇痛中得到越来越多的应用，尤其是应用在膝关节置换术后镇痛。文章综述了布比卡因脂质体应用于膝关节置换手术后镇痛的应用进展情况。

Abstract: The traumatic stimulus produced by knee replacement surgery often causes patients to suffer from moderate to severe pain after surgery, which not only makes the patient’s postoperative experience poor, but also aggravates the internal environmental disorders of the body, which adversely affects the patient’s postoperative recovery. Nowadays, the concept of multimodal analgesia is more and more often applied to postoperative analgesia, which is to reasonably and effectively combine multiple analgesic drugs and analgesic methods with different mechanisms to exert the best analgesic effect. Liposomal bupivacaine, as a new type of sustained-release local anesthetic with stability and long-acting characteristics, has been increasingly used in postoperative multimodal analgesia, especially in postoperative analgesia after knee arthroplasty. This article reviews the progress of liposomal bupivacaine application for postoperative analgesia after knee replacement surgery.