肥胖与心衰联系研究进展
Progress in the Study of the Link between Obesity and Heart Failure
DOI: 10.12677/acm.2025.153775, PDF,    科研立项经费支持
作者: 顾晏羽, 徐 景, 郭小玉, 美娃·赛力克, 努尔孜巴·阿吉, 热甫开提·阿不都哈力克*：新疆医科大学第一临床医学院，新疆 乌鲁木齐
关键词: 肥胖；心力衰竭；肥胖悖论；Obesity； Heart Failure； Obesity Paradox
摘要: 肥胖已成为全球性公共健康问题，其与心力衰竭(HF)的关联日益受到关注。该综述旨在梳理肥胖导致心力衰竭的流行病学、治疗、预后等方面的相关研究进展。阐述了肥胖通过多种病理生理机制，如血液动力学改变、神经激素激活、脂肪因子和脂肪毒性等增加心力衰竭发病风险。还提及肥胖悖论现象及其可能原因，最后对肥胖合并心力衰竭的治疗策略进行综述，强调综合管理的重要性，以增进对这一领域的理解并为临床实践提供参考。
Abstract: Obesity has become a global public health problem, and its association with heart failure (HF) has received increasing attention. The aim of this review is to sort out the research progress related to the epidemiology, treatment, and prognosis of obesity-induced heart failure. It is described that obesity increases the risk of developing heart failure through various pathophysiological mechanisms, such as hemodynamic alterations, neurohormonal activation, adipokines, and adipotoxicity. The phenomenon of the obesity paradox and its possible causes are also mentioned, and finally, a review of therapeutic strategies for obesity-combined heart failure is presented, emphasizing the importance of comprehensive management in order to improve the understanding of this field and to inform clinical practice.
文章引用：顾晏羽, 徐景, 郭小玉, 美娃·赛力克, 努尔孜巴·阿吉, 热甫开提·阿不都哈力克. 肥胖与心衰联系研究进展[J]. 临床医学进展, 2025, 15(3): 1546-1552. https://doi.org/10.12677/acm.2025.153775

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