痰瘀互结证高血压研究热点与趋势的可视化分析

Visual Analysis of Research Hotspots and Trends of Hypertension with Phlegm and Blood Stasis Syndrome

摘要: 目的：系统梳理2003~2023年高血压痰瘀互结证领域的研究动态及前沿热点，揭示其学术发展脉络。方法：以中国知网(CNKI)、万方(Wanfang)、维普(VIP)数据库中2003年1月1日至2023年12月31日收录的高血压痰瘀互结证相关文献为研究对象，通过文献计量学方法对符合纳入标准的355篇文献进行定量分析，运用可视化技术对发文量时序分布、作者合作网络、机构协作关系及关键词共现网络进行图谱解析。结果：1) 年度发文量呈阶梯式增长，2010年后进入快速发展期(年均增长率达15.6%)；2) 研究力量分布呈现核心作者引领与机构间协作不足的双重特征：韩学杰团队(累计发文23篇)及中国中医科学院中医临床基础医学研究所(发文量占比18.3%)为领域内主要贡献者，但73.5%的作者为独立发文，跨机构合作率不足10%；3) 关键词聚类分析显示，研究热点聚焦于四大主题：痰瘀互结证病理机制(如血脂异常、一氧化氮/内皮素失衡)、中医干预策略(化痰祛瘀复方、针药并用)、临床疗效评价(证候积分改善率)及生物标志物探索(炎症因子CRP、TNF-α)。结论：我国学者在高血压痰瘀互结证领域开展了积极且富有成效的研究，整体发展态势良好，研究广度和深度持续拓展。然而，目前的研究多集中于基础理论和临床实践层面，建议未来进一步深入分子水平和细胞机制的研究，并加强多机构间的合作与交流，以推动该领域的创新发展。

Abstract: Objective: To systematically analyze the research trends and hotspots in the field of hypertension with phlegm and stasis interconnection from 2003 to 2023, and to reveal its academic development. Methods: Taking the literature related to hypertension phlegm and stasis syndrome included in the databases of China National Knowledge Infrastructure (CNKI), Wanfang and VIP from January 1, 2003 to December 31, 2023 as the research object, 355 pieces of literature meeting the inclusion criteria were quantitatively analyzed by bibliometric methods, and visualization techniques were used to analyze the temporal distribution of the number of articles, the authors’ collaborative network, Institutional Collaboration Network and Keyword Co-occurrence Network. Results: 1) The annual number of published papers increased step by step, and entered a period of rapid development after 2010 (with an average annual growth rate of 15.6%). 2) The distribution of research strength showed the dual characteristics of core author leadership and insufficient inter-agency collaboration: Han Xuejie’s team (23 articles in total) and the Institute of Clinical Basic Medicine of Chinese Academy of Chinese Medical Sciences (18.3 % of the total) were the main contributors in the field, but 73.5% of the authors were independent, and the cross-agency cooperation rate was less than 10%. 3) Keywords cluster analysis showed that the research hotspots focused on four major topics: the pathological mechanism of phlegm and blood stasis syndrome (such as dyslipidemia, nitric oxide/endothelin imbalance), TCM intervention strategies (Huatan Quyu compound, acupuncture and medicine), clinical efficacy evaluation (syndrome score improvement rate) and biomarker exploration (inflammatory factors CRP, TNF-α). Conclusion: Chinese scholars have carried out active and fruitful research in the field of hypertension phlegm and blood stasis syndrome. The overall development trend is good, and the breadth and depth of research continue to expand. However, the current research mostly focuses on the basic theory and clinical practice. It is suggested that further research on molecular level and cellular mechanism should be carried out in the future, and cooperation and communication among multiple institutions should be strengthened to promote innovative development in this field.