浅析《景岳全书》治疗不寐的用药规律

Analysis on Medication Rules of Treating Insomnia in Jing Yue Quan Shu

摘要: 目的：对《景岳全书》治疗不寐的组方用药规律进行探究，分析治疗不寐的核心药物组合，为临床用药提供新思路。方法：筛选《景岳全书·理集·卷十八》中“不寐论列方”，在Excel中建立数据库，运用SPSS Statistics25.0、SPSS Modeler18.0对数据库进行分析。结果：提取方剂30首，以和阵、补阵居多；涉及中药70味，高频用药22味，前3位依次为甘草、人参、当归；高频药物功效以补虚药为主，其次为利水渗湿、安神药等；药性以温居多；药味以甘为主；多归脾、肺经；聚类分析得到4类药物组合；关联分析得到12组关联药组和3对强关联药对。结论：张景岳治疗不寐善于调补阴阳，重视扶正固本，兼顾利水渗湿；灵活配伍、分证论治；同时从太阴出发，治在脾肺，重在调畅气机。

Abstract: Objective: To investigate the pattern of the formulas of Jing Yue Quan Shu for the treatment of insomnia, the core drug combinations for the treatment of insomnia, and to provide new ideas for the clinic. Methods: The Insomnia Treatise was selected in Jing Yue Quan Shu·Liji·Volume eighteen, established the database in Excel and used SPSS Statistics25.0, SPSS Modeler18.0 to analyze the database. Results: 30 prescriptions were extracted, with most of them being Hezhen and Buzhen; 70 kinds of traditional Chinese medicine were involved, with 22 high-frequency flavors, the top three being licorice, ginseng, and angelica; the efficacy of high-frequency drugs was mainly tonic, followed by diuretic and tranquilizing medicines, etc. The nature of the medicines were mostly warm; the taste of the medicines were dominated by sweetness; most of them were attributed to the spleen and lung meridians; the clustering of 4 types of drug combinations; and the association of 12 groups of associated medicines and 3 pairs of strongly associated medicinal pairs. Conclusion: Zhang Jingyue is good at regulating and tonifying yin and Yang in treating insomnia, attaching importance to strengthening the body resistance and consolidating the constitution, taking into account diuresis and eliminating dampness; at the same time, it starts from Taiyin, treats the spleen and lung, and focuses on regulating qi.