研究NT-proBNP、ALB联合FIB与老年CHF患者预后的相关性

To Study the Correlation between NT-proBNP, ALB Combined with FIB and the Prognosis of Elderly Patients with CHF

摘要: 目的：本研究旨在探讨NT-proBNP、ALB联合FIB与老年慢性心力衰竭(Chronic Heart Failure, CHF)预后相关性。方法：本研究选取了邯郸市中心医院2021年1月至2023年1月期间于心血管内科住院的120例老年慢性心力衰竭患者，收集一般临床资料、实验室资料及随访信息等。一般临床资料包括：年龄、性别、收缩压、舒张压、心率，以及既往的吸烟史；实验室资料包括：血常规、生化(FIB、ALB、LDL、HDL等)、NT-proBNP；随访资料包括：心血管不良事件的发生(恶性心律失常、急性心肌梗死、急性脑血管病等)。根据患者是否发生主要心血管不良事件(MACE)，分为MACE组和非MACE组，比较两组患者一般基线资料、主要实验室指标。通过单因素和多因素Logistic回归分析老年慢性心力衰竭患者1年内发生MACE风险，通过ROC曲线评估NT-proBNP、ALB联合FIB对老年慢性心力衰竭一年内MACE预测价值。结果：(1) 老年慢性心力衰竭患者MACE组的年龄、FIB、NT-proBNP及Cl较非MACE组高，而ALB较非MACE组低。(2) 单因素与多因素Logistic回归分析结果表明，NT-proBNP、ALB及FIB是老年慢性心力衰竭患者在一年内MACE的独立风险因素。(3) NT-proBNP、ALB联合FIB对老年CHF患者1年内MACE发生有良好的预测效果。结论：老年慢性心力衰竭1年内MACE发生率高；NT-proBNP、ALB联合FIB对老年慢性心力衰竭患者1年内MACE发生有良好的预测价值。

Abstract: Objective: This study aims to explore the correlation between NT-proBNP, ALB combined with FIB and the prognosis of elderly patients with chronic heart failure (CHF). Methods: This study selected 120 elderly patients with chronic heart failure who were hospitalized in the Department of Cardiology of Hospital from January 2021 to January 2023. General clinical data, laboratory data and follow-up information were collected. General clinical data included: age, gender, systolic blood pressure, diastolic blood pressure, heart rate, and smoking history; laboratory data included: blood routine, biochemistry (FIB, ALB, LDL, HDL, etc.), NT-proBNP; follow-up data included: occurrence of adverse cardiovascular events (malignant arrhythmia, acute myocardial infarction, acute cerebrovascular disease, etc.). According to whether the patients had major adverse cardiovascular events (MACE), they were divided into MACE group and non-MACE group, and the general baseline data and main laboratory indicators of the two groups were compared. Univariate and multivariate Logistic regression analysis were used to analyze the risk of MACE in elderly patients with chronic heart failure within one year, and the predictive value of NT-proBNP, ALB combined with FIB for MACE within one year in elderly patients with chronic heart failure was evaluated by ROC curve. Results: (1) The age, FIB, NT-proBNP, and Cl of the MACE group of elderly patients with chronic heart failure were higher than those of the non-MACE group, while ALB was lower than that of the non-MACE group. (2) The results of univariate and multivariate Logistic regression analysis showed that NT-proBNP, ALB and FIB were independent risk factors for MACE within one year in elderly patients with chronic heart failure. (3) NT-proBNP, ALB combined with FIB had a good predictive effect on the occurrence of MACE within one year in elderly CHF patients. Conclusion: The incidence of MACE within one year in elderly patients with chronic heart failure is high; NT-proBNP, ALB combined with FIB have good predictive value for MACE within one year in elderly patients with chronic heart failure.