异补骨脂二氢黄酮的生物活性研究进展
Research Progress on the Biological Activity of Isobavachin
DOI: 10.12677/jocr.2025.131007, PDF,   
作者: 张文渊:兰州交通大学生物与制药工程学院,甘肃 兰州
关键词: 天然产物异补骨脂二氢黄酮生物活性Natural Product Isobavachin Biological Activity
摘要: 异补骨脂二氢黄酮(Isobavachin)是一种异戊二烯基化的二氢黄酮类化合物,主要存在于豆科植物补骨脂(Psoralea corylifolia Linn.)中,具有广泛的药理作用和生理活性,如治疗组织疏松、抗炎、抗高尿酸血症等。近年来,随着生物技术的进步,人们对天然产物异补骨脂二氢黄酮的生物活性进行了更为深入的研究。本文将梳理天然产物异补骨脂二氢黄酮生物活性的最新研究进展。
Abstract: Isobavachin is an isoprenylated dihydroflavonoid compound, which is mainly found in the leguminous plant Psoralea corylifolia Linn. It has a wide range of pharmacological and physiological activities, such as the treatment of tissue looseness, anti-inflammation, and anti-hyperuricemia. In recent years, with the advancement of biotechnology, people have conducted more in-depth research on the biological activity of the natural product Isobavachin. This article will review the latest research progress on the biological activity of the natural product Isobavachin.
文章引用:张文渊. 异补骨脂二氢黄酮的生物活性研究进展[J]. 有机化学研究, 2025, 13(1): 70-76. https://doi.org/10.12677/jocr.2025.131007

参考文献

[1] Haraguchi, H., Inoue, J., Tamura, Y. and Mizutani, K. (2002) Antioxidative Components of Psoralea corylifolia (Leguminosae). Phytotherapy Research, 16, 539-544. [Google Scholar] [CrossRef] [PubMed]
[2] Guo, J.N., et al. (2005) Antioxidants from a Chinese Medicinal Herb—Psoralea corylifolia L. Food Chemistry, 91, 287-292. [Google Scholar] [CrossRef
[3] Wang, D., Li, F. and Jiang, Z. (2001) Osteoblastic Proliferation Stimulating Activity of Psoralea corylifolia Extracts and Two of Its Flavonoids. Planta Medica, 67, 748-749. [Google Scholar] [CrossRef] [PubMed]
[4] Cho, H., Jun, J., Song, E., Kang, K., Baek, H., Ko, Y., et al. (2001) Bakuchiol: A Hepatoprotective Compound of Psoralea corylifolia on Tacrine-Induced Cytotoxicity in Hep G2 Cells. Planta Medica, 67, 750-751. [Google Scholar] [CrossRef] [PubMed]
[5] Chung, Y.C., Song, S.J., Lee, A., Jang, C.H., Kim, C. and Hwang, Y. (2024) Isobavachin, a Main Bioavailable Compound in Psoralea corylifolia, Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Macrophages and Zebrafish by Suppressing the MAPK and NF-κB Signaling Pathways. Journal of Ethnopharmacology, 321, Article ID: 117501. [Google Scholar] [CrossRef] [PubMed]
[6] Torres, S.L., Arruda, M.S.P., Arruda, A.C., Müller, A.H. and Silva, S.C. (2000) Flavonoids from Brosimum acutifolium. Phytochemistry, 53, 1047-1050. [Google Scholar] [CrossRef] [PubMed]
[7] Li, W.D., Yan, C.P., Wu, Y., Weng, Z.B., Yin, F.Z., Yang, G.M., et al. (2014) Osteoblasts Proliferation and Differentiation Stimulating Activities of the Main Components of Fructus Psoraleae corylifoliae. Phytomedicine, 21, 400-405. [Google Scholar] [CrossRef] [PubMed]
[8] Wätjen, W., Weber, N., Lou, Y., Wang, Z., Chovolou, Y., Kampkötter, A., et al. (2007) Prenylation Enhances Cytotoxicity of Apigenin and Liquiritigenin in Rat H4IIE Hepatoma and C6 Glioma Cells. Food and Chemical Toxicology, 45, 119-124. [Google Scholar] [CrossRef] [PubMed]
[9] Wu, C., Gao, M., Chen, J., Sun, X., Zhang, K., Dai, Y., et al. (2022) Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells. Molecules, 27, Article No. 6787. [Google Scholar] [CrossRef] [PubMed]
[10] Matsuda, H., Kiyohara, S., Sugimoto, S., Ando, S., Nakamura, S. and Yoshikawa, M. (2009) Bioactive Constituents from Chinese Natural Medicines. XXXIII. Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages. Biological and Pharmaceutical Bulletin, 32, 147-149. [Google Scholar] [CrossRef] [PubMed]
[11] Nepal, M., Jung Choi, H., Choi, B., Lim Kim, S., Ryu, J., Hee Kim, D., et al. (2012) Anti-Angiogenic and Anti-Tumor Activity of Bavachinin by Targeting Hypoxia-Inducible Factor-1α. European Journal of Pharmacology, 691, 28-37. [Google Scholar] [CrossRef] [PubMed]
[12] Kim, T., Jung, J.W., Ha, B.G., Hong, J.M., Park, E.K., Kim, H., et al. (2011) The Effects of Luteolin on Osteoclast Differentiation, Function in Vitro and Ovariectomy-Induced Bone Loss. The Journal of Nutritional Biochemistry, 22, 8-15. [Google Scholar] [CrossRef] [PubMed]
[13] Park, S.B., Lee, Y.J. and Chung, C.K. (2010) Bone Mineral Density Changes after Ovariectomy in Rats as an Osteopenic Model: Stepwise Description of Double Dorso-Lateral Approach. Journal of Korean Neurosurgical Society, 48, Article No. 309. [Google Scholar] [CrossRef] [PubMed]
[14] Shiraishi, A., Miyabe, S., Nakano, T., Umakoshi, Y., Ito, M. and Mihara, M. (2009) The Combination Therapy with Alfacalcidol and Risedronate Improves the Mechanical Property in Lumbar Spine by Affecting the Material Properties in an Ovariectomized Rat Model of Osteoporosis. BMC Musculoskeletal Disorders, 10, Article No. 66. [Google Scholar] [CrossRef] [PubMed]
[15] Riggs, B.L., Khosla, S. and Melton, L.J. (2002) Sex Steroids and the Construction and Conservation of the Adult Skeleton. Endocrine Reviews, 23, 279-302. [Google Scholar] [CrossRef] [PubMed]
[16] Ducy, P., Schinke, T. and Karsenty, G. (2000) The Osteoblast: A Sophisticated Fibroblast under Central Surveillance. Science, 289, 1501-1504. [Google Scholar] [CrossRef] [PubMed]
[17] Sozen, T., Ozisik, L. and Calik Basaran, N. (2017) An Overview and Management of Osteoporosis. European Journal of Rheumatology, 4, 46-56. [Google Scholar] [CrossRef] [PubMed]
[18] Lin, J.T. and Lane, J.M. (2004) Osteoporosis. Clinical Orthopaedics and Related Research, 425, 126-134. [Google Scholar] [CrossRef
[19] Wang, X., Chen, B., Sun, J., Jiang, Y., Zhang, H., Zhang, P., et al. (2018) Iron-Induced Oxidative Stress Stimulates Osteoclast Differentiation via NF-κB Signaling Pathway in Mouse Model. Metabolism, 83, 167-176. [Google Scholar] [CrossRef] [PubMed]
[20] Rensvold, J.W., Krautkramer, K.A., Dowell, J.A., Denu, J.M. and Pagliarini, D.J. (2016) Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis. Journal of Biological Chemistry, 291, 20827-20837. [Google Scholar] [CrossRef] [PubMed]
[21] Gattermann, N. (2016) Iron Rusting in the Mitochondria? Blood, 128, 1907-1908. [Google Scholar] [CrossRef] [PubMed]
[22] Li, T., Du, Y., Yao, H., Zhao, B., Wang, Z., Chen, R., et al. (2024) Isobavachin Attenuates Osteoclastogenesis and Periodontitis-Induced Bone Loss by Inhibiting Cellular Iron Accumulation and Mitochondrial Biogenesis. Biochemical Pharmacology, 224, Article ID: 116202. [Google Scholar] [CrossRef] [PubMed]
[23] Guzik, T., Korbut, R. and Adamek-Guzik, T. (2003) Nitric Oxide and Superoxide in Inflammation. Journal of Physiology and Pharmacology, 54, 469-487.
[24] Hirayama, D., Iida, T. and Nakase, H. (2017) The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis. International Journal of Molecular Sciences, 19, Article No. 92. [Google Scholar] [CrossRef] [PubMed]
[25] Liu, T., Zhang, L., Joo, D. and Sun, S. (2017) NF-κB Signaling in Inflammation. Signal Transduction and Targeted Therapy, 2, Article No. 17023. [Google Scholar] [CrossRef] [PubMed]
[26] Kany, S., Vollrath, J.T. and Relja, B. (2019) Cytokines in Inflammatory Disease. International Journal of Molecular Sciences, 20, Article No. 6008. [Google Scholar] [CrossRef] [PubMed]
[27] Dehlin, M., Jacobsson, L. and Roddy, E. (2020) Global Epidemiology of Gout: Prevalence, Incidence, Treatment Patterns and Risk Factors. Nature Reviews Rheumatology, 16, 380-390. [Google Scholar] [CrossRef] [PubMed]
[28] Pasalic, D., Marinkovic, N. and Feher-Turkovic, L. (2012) Uric Acid as One of the Important Factors in Multifactorial Disorders-Facts and Controversies. Biochemia Medica, 22, 63-75.
[29] Keenan, R.T. (2020) The Biology of Urate. Seminars in Arthritis and Rheumatism, 50, S2-S10. [Google Scholar] [CrossRef] [PubMed]
[30] Chen, X., Zhao, Z., Luo, J., Wu, T., Shen, Y., Chang, S., et al. (2021) Novel Natural Scaffold as hURAT1 Inhibitor Identified by 3d-Shape-Based, Docking-Based Virtual Screening Approach and Biological Evaluation. Bioorganic Chemistry, 117, Article ID: 105444. [Google Scholar] [CrossRef] [PubMed]
[31] Bibert, S., Hess, S.K., Firsov, D., Thorens, B., Geering, K., Horisberger, J., et al. (2009) Mouse GLUT9: Evidences for a Urate Uniporter. American Journal of Physiology-Renal Physiology, 297, F612-F619. [Google Scholar] [CrossRef] [PubMed]
[32] Zhao, Z., Luo, J., Liao, H., Zheng, F., Chen, X., Luo, J., et al. (2023) Pharmacological Evaluation of a Novel Skeleton Compound Isobavachin (4’,7-Dihydroxy-8-Prenylflavanone) as a Hypouricemic Agent: Dual Actions of URAT1/GLUT9 and Xanthine Oxidase Inhibitory Activity. Bioorganic Chemistry, 133, Article ID: 106405. [Google Scholar] [CrossRef] [PubMed]
[33] Zhao, Z., Chen, X., Luo, J., Chen, M., Luo, J., Chen, J., et al. (2024) Design, Synthesis and Bioactivity Evaluation of Isobavachin Derivatives as hURAT1 Inhibitors for Hyperuricemia Agents. European Journal of Medicinal Chemistry, 277, Article ID: 116753. [Google Scholar] [CrossRef] [PubMed]