外泌体在肝内胆管癌诊疗中的作用
The Role of Exosomes in the Diagnosis and Treatment of Intrahepatic Cholangiocarcinoma
DOI: 10.12677/acm.2025.1541001, PDF,   
作者: 王乾昌*, 王 哲：山东第一医科大学研究生院，山东 济南；祝训浩*：潍坊市益都中心医院肝胆胰外科，山东 潍坊；刘方峰#：山东第一医科大学附属省立医院奥体院区肝胆外科，山东 济南
关键词: 肝内胆管癌；外泌体；生物标志物；肿瘤微环境；细胞间通讯；Intrahepatic Cholangiocarcinoma； Exosomes； Biomarkers； Tumor Microenvironment； Intercellular Communication
摘要: 目的：原发性肝内胆管癌是一组预后极差的异质性肿瘤，其主要起源于胆管内皮细胞，由于其症状比较隐匿，在确诊时往往肿瘤已经到达晚期，因此预后很差。早期诊断预后预测和有效的治疗仍是提高肝内胆管癌患者生存质量的关键。外泌体是一种小分子磷脂双层囊泡，其属于细胞外囊泡的一种亚型，可以携带多种类型的生物分子，如蛋白质，RNA，DNA，代谢物和脂质，使其成为潜在的肿瘤生物标志物和参与人体多种生物活动的调节。本文综述了外泌体在肝内胆管癌发生发展机制中的作用及其作为疾病生物标志物的潜在用途。
Abstract: Objective: Intrahepatic cholangiocarcinoma (ICC) represents a heterogeneous group of tumors with an extremely poor prognosis, primarily originating from the epithelial cells of the bile duct. Owing to its subtle symptoms, ICC is frequently diagnosed at an advanced stage, resulting in an unfavorable prognosis. Early diagnosis, prognosis prediction, and effective treatment remain imperative to enhance the quality of life for ICC patients. Exosomes, a subtype of extracellular vesicles, are small phospholipid bilayer vesicles capable of transporting a variety of biomolecules, including proteins, RNA, DNA, metabolites, and lipids. This endows them with the potential to serve as cancer biomarkers and regulators participating in diverse biological activities within the human body. This article comprehensively reviews the role of exosomes in the mechanisms underlying the occurrence and development of intrahepatic cholangiocarcinoma, highlighting their prospective applications as disease biomarkers.
文章引用：王乾昌, 祝训浩, 刘方峰, 王哲. 外泌体在肝内胆管癌诊疗中的作用[J]. 临床医学进展, 2025, 15(4): 830-834. https://doi.org/10.12677/acm.2025.1541001

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