蒙药森登-4汤对p38-MAPK/NF-κB信号通络干预膝关节骨性关节炎的作用机制研究

Study on the Mechanism of Action of Mongolian Medicine Sendeng-4 Decoction in Intervening Knee Osteoarthritis through the p38-MAPK/NF-κB Signaling Pathway

摘要: 文章分析了蒙药森登-4汤对p38-MAPK/NF-κB信号通络干预膝关节骨性关节炎的作用机制。方法：选择2021年01月~2023年12月来医院治疗全膝关节置换术的膝关节骨性关节炎患者60例，随机分成两组，每组30例患者，年龄40~80岁，平均年龄为57岁。治疗组与对照组两组p38-MAPK、NF-κB及其磷酸化、IL-1、IL-6、IL-1β、TNF-α表达情况进行比较。结果：对照组与治疗组相比p38-MAPK、p65-NF-κB及其磷酸化、IL-1、IL-6、IL-1β、TNF-α表达水平都有显著升高， 差异均有统计学意义(P < 0.05)。结论：研究结果说明，蒙药森登-4汤对p38-MAPK/NF-κB信号通络干预膝关节骨性关节炎有显著效果，不良反应少。

Abstract: This paper studies the Mechanism of Action of Mongolian Medicine Sendeng-4 Decoction in Intervening Knee Osteoarthritis through the p38-MAPK/NF-κB Signaling Pathway. Methods: Sixty patients with knee osteoarthritis who underwent total knee arthroplasty in the hospital from January 2021 to December 2023 were selected and randomly divided into two groups, with 30 cases in each group. The age range was 40 to 80 years old, with an average age of 57 years. The expression levels of p38-MAPK, NF-κB and their phosphorylated forms, IL-1, IL-6, IL-1β, and TNF-α were compared between the treatment group and the control group. Results: Compared with the treatment group, the expression levels of p38-MAPK, p65-NF-κB and their phosphorylated forms, IL-1, IL-6, IL-1β, and TNF-α in the control group were significantly increased, and the differences were statistically significant (P < 0.05). Conclusion: The research results indicate that Mongolian Medicine Sendeng-4 Decoction has a significant effect in intervening knee osteoarthritis through the p38-MAPK/NF-κB signaling pathway, with few adverse reactions.