蒙药润骨灵治疗膝关节骨性关节炎的临床研究进展

Clinical Research Progress of Mongolian Medicine Runguling in the Treatment of Knee Osteoarthritis

摘要: 蒙药润骨灵是内蒙古自治区国际蒙医医院巴虎山教授经过多年临床工作总结并应用的验方，它是在蒙药升阳-10味和苏木-6味汤的基础上研制出的方剂，方剂组成是豆蔻、苏木、槟榔、高良姜、草果、木香、黄精、手掌参、天门冬、肉豆蔻、丁香、沉香等12味草药，有补肾、增加清浊代谢、滋补骨，降赫依的作用，临床上主要用于骨性关节炎、骨质疏松症、骨伤、体虚等的治疗。在临床上使用已经10年有余，纯草药成分副作用小和价格低廉。近年来，对该领域药物的研发方向在朝向疗效好、毒副作用小、多靶点治疗的生物技术药物、单克隆抗体的方向发展，促使传统医药及复方制剂的研发及二次开发有了长足发展。但是蒙医药尚缺，因此开发新型的、毒副作用小的治疗骨性关节炎的新型蒙药显得急迫。润骨灵已经越来越受到临床及科研工作者关注。本文在前期总结关于蒙药润骨灵的研究，并提出现阶段存在的问题，为进一步探讨蒙药润骨灵的研发及在骨科当中更广泛的运用提供参考。

Abstract: Mongolian medicine Runguling is a proven prescription summarized and applied by Professor Bahushan of the International Mongolian Hospital of Inner Mongolia Autonomous Region after many years of clinical work. It is a prescription developed on the basis of Mongolian medicine Shengyang-10 Flavors and Su Mu-6 Flavors Decoction. The prescription is composed of 12 herbs such as cardamom, sappanwood, betel nut, galangal, tsaoko amomum fruit, costus root, polygonatum, ginseng, asparagus, nutmeg, clove, and agilawood. It has the effects of tonifying the kidney, increasing the metabolism of turbidity and clarity, nourishing the bones, and reducing “Heyi”. It is mainly used clinically for the treatment of osteoarthritis, osteoporosis, bone injuries, and weakness. It has been used clinically for more than 10 years. The pure herbal ingredients have few side effects and are low in price. In recent years, the research and development direction of drugs in this field is developing towards biotechnological drugs and monoclonal antibodies with good curative effect, low toxic and side effects, and multi-target treatment, promoting the research and development and secondary development of traditional medicine and compound preparations. However, Mongolian medicine is still lacking. Therefore, it is urgent to develop a new type of Mongolian medicine with low toxic and side effects for the treatment of osteoarthritis. Runguling has received more and more attention from clinical and scientific researchers. This article summarizes the previous research on Mongolian medicine Runguling and puts forward the existing problems at the present stage, providing a reference for further exploring the research and development of Mongolian medicine Runguling and its wider application in orthopedics.