硫叶立德参与的特定类型反应在杂环合成中的应用
Applications of Sulfur Ylide-Mediated Specific Reaction Types in Heterocyclic Synthesis
DOI: 10.12677/amc.2025.132025, PDF,   
作者: 张芳芳：浙江师范大学化学与材料科学学院，浙江 金华
关键词: 杂环化合物；硫叶立德；环加成反应；Heterocyclic Compounds； Sulfur Ylides； Cycloaddition Reactions
摘要: 在杂环化合物的合成方法学中，硫叶立德因其独特的亲核性与反应多样性展现出显著优势。通过[3 + 2]、[2 + 1]、[4 + 1]等环加成策略，硫叶立德可实现三元、五元及扩环系的高效构建。目前，该类反应已成功应用于抗肿瘤药物(如喹啉类化合物)、天然产物(如萜类环丙烷衍生物)及光电功能材料(如噻吩共轭聚合物)的开发，凸显了其在合成化学中的应用价值。
Abstract: In the methodology of heterocyclic compound synthesis, sulfur ylides demonstrate remarkable advantages due to their unique nucleophilicity and reaction diversity. Through [3 + 2], [2 + 1], [4 + 1], and other cycloaddition strategies, sulfur ylides enable efficient construction of three-membered, five-membered, and expanded ring systems. Currently, such reactions have been successfully applied in the development of antitumor agents (e.g., quinoline derivatives), natural products (e.g., terpenoid cyclopropane derivatives), and optoelectronic functional materials (e.g., thiophene-based conjugated polymers), highlighting their significant value in synthetic chemistry.
文章引用：张芳芳. 硫叶立德参与的特定类型反应在杂环合成中的应用[J]. 材料化学前沿, 2025, 13(2): 225-235. https://doi.org/10.12677/amc.2025.132025

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