探究特利加压素、生长抑素和垂体后叶素三种血管活性药物治疗肝硬化食管胃底静脉曲张破裂出血的临床效果及经济性分析

To Explore the Clinical Effect and Economic Analysis of Three Kinds of Vasoactive Drugs, Triptetrin, Somatostatin and Posterior Pituitary Hormone, in the Treatment of Rupture Bleeding of Esophageal and Gastric Varices in Cirrhosis

摘要: 食管静脉曲张是肝硬化诱发的门静脉高压的主要临床表现之一，约40%的肝硬化患者会出现食管静脉曲张，50%~60%的食管静脉曲张患者会并发大出血，也就是急性食管静脉曲张出血，其主要特征为来势迅猛、出血量大、病情凶险、病死率高(>40%)等。本文综述了特利加压素、生长抑素和垂体后叶素三种血管活性药物治疗肝硬化食管胃底静脉曲张破裂出血的临床效果及经济性。通过分析相关文献，比较了三种药物的作用机制、临床疗效、安全性和经济性。结果表明，特利加压素在止血效果和安全性方面优于生长抑素和垂体后叶素，且可能具有更好的经济性。本研究为临床合理用药提供了参考依据，对优化治疗方案、提高治疗效果和降低医疗成本具有重要意义。

Abstract: Esophageal varices is one of the main clinical manifestations of cirrhosis induced portal hypertension, about 40% of patients with cirrhosis will appear esophageal varices, 50%~60% of patients with esophageal varices will have massive bleeding, also is acute esophageal varices bleeding, its main characteristics for rapid, bleeding, dangerous, high case fatality rate (>40%), etc. This review summarizes the clinical effects and economy of three vasoactive drugs: terlipressin, somatostatin and retropituitary, in the treatment of esophageal and gastric varices in cirrhosis. By analyzing the relevant literature, the mechanism of action, clinical efficacy, safety and economy of the three drugs were compared. The results show that terlipressin is superior to somatostatin and retropituitary in hemostatic efficacy and safety, and may be better economical. This study provides a reference for the rational use of clinical drugs, and is of great significance to optimize the treatment plan, improve the treatment effect and reduce the medical cost.