铁死亡调控代谢相关脂肪性肝病的研究进展
Research Advances on the Regulation of Ferroptosis in Metabolic Dysfunction-Associated Fatty Liver Disease
摘要: 铁死亡是近年发现的一种铁依赖的非凋亡性的程序性细胞死亡方式，其主要特征包括铁稳态失衡与脂质过氧化。代谢相关脂肪性肝病(Metabolic dysfunction-Associated Fatty Liver Disease, MAFLD)是与肥胖、胰岛素抵抗等相关的一种代谢性疾病，其正迅速成为全球慢性肝病最常见的病因之一。研究指出，铁死亡在MAFLD的病理进展中起着关键作用，抑制铁死亡可能成为MAFLD的一种新的治疗策略。本文对近年来铁死亡在MAFLD中作用分子细胞机制、铁死亡的检测及铁死亡抑制剂治疗MAFLD的临床研究进展进行总结，以期为治疗MAFLD提供新的思路及研究方向。
Abstract: Ferroptosis is an iron-dependent, non-apoptotic, programmed cell death, characterized by iron homeostasis and lipid peroxidation. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a metabolic disorder associated with obesity and insulin resistance, and it is rapidly becoming one of the most common causes of chronic liver disease worldwide. Studies have indicated that ferroptosis plays an important regulatory role in the occurrence and development of MAFLD, and ferroptosis may be a new therapeutic target for MAFLD. In this paper, the molecular and cellular mechanisms of ferroptosis in MAFLD, the detection of ferroptosis and the latest progress in clinical research on the treatment of MAFLD with ferroptosis inhibitors were summarized in order to provide new ideas and research directions for the treatment of MAFLD.
文章引用：谢婉婷, 谭婉燕. 铁死亡调控代谢相关脂肪性肝病的研究进展[J]. 临床医学进展, 2025, 15(4): 2557-2565. https://doi.org/10.12677/acm.2025.1541213

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