中医药调控原发性肝癌相关信号通路研究进展
Research Progress on the Regulation of Signaling Pathways Related to Primary Liver Cancer by Traditional Chinese Medicine
DOI: 10.12677/tcm.2025.144232, PDF,    科研立项经费支持
作者: 张 强*, 乔 杰, 韦思玲, 张 政, 颜士朝, 郭 徽：广西中医药大学研究生院，广西 南宁；许 斌#：广西中医药大学第一附属医院肝胆外科，广西 南宁
关键词: 中医药；肝癌；研究进展；信号通路；发病机制；Traditional Chinese Medicine； Liver Cancer； Research Progress； Signal Pathway； Pathogenesis
摘要: 原发性肝癌(PLC)是一种我国常见的恶性肿瘤，有较高的发生率和死亡率，目前西医主要采取外科手术治疗和消融治疗，虽然对肝癌症状具有一定疗效，但大多数患者发现已是中晚期，已经失去最佳治疗时机。近年来，随着中医药对原发性肝癌的研究日益增多，其不仅可以通过调整患者的体质，提高病人的免疫力，扶正固本，还可以通过外敷、口服中药汤剂、中药离子介入等方式结合治疗，通过调控体内信号传导方式来影响肝癌细胞因子，从而达到治疗肝癌相关疾病的作用。目前大部分文章都是以中医药防治肝癌为主，而缺乏通过信号通路以及发病机制的总结性研究。本文重点论述了近些年来中医药治疗肝癌相关信号通路的研究进展，即RaF/MEK/ERK通路、PI3K/AKT/mTOR通路、WNT/β-catenin通路、肝细胞生长因子/c-MET通路、生长因子调节的血管生成信号途径。通过阐述肝癌的发病机制，为治疗肝癌提供一些靶点和临床思路。
Abstract: Primary liver cancer (PLC) is a common malignant tumor in China, with a high incidence and mortality rate. At present, Western medicine mainly adopts surgical treatment and ablation treatment, although it has a certain effect on liver cancer symptoms, but most patients are found to be in the middle and advanced stages and have lost the best treatment opportunity. In recent years, with the increasing research on primary liver cancer in traditional Chinese medicine, it can not only improve the patient’s immunity by adjusting the patient’s physique, but also strengthen the foundation. It can also be combined with external application, oral Chinese medicine decoction, traditional Chinese medicine ion intervention, etc., to affect liver cancer cytokines by regulating the signal transduction mode in vivo, so as to achieve the effect of treating liver cancer-related diseases. At present, most of the articles focus on the prevention and treatment of liver cancer with traditional Chinese medicine, but there is a lack of summary research on signaling pathways and pathogenesis. This article discusses the research progress of TCM in the treatment of HCC-related signaling pathways, namely RaF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/β-catenin pathway, hepatocyte growth factor/c-MET pathway, and growth factor-regulated angiogenic signaling pathway. This article provides some targets and clinical ideas for the treatment of liver cancer by elaborating on the pathogenesis of liver cancer.
文章引用：张强, 许斌, 乔杰, 韦思玲, 张政, 颜士朝, 郭徽. 中医药调控原发性肝癌相关信号通路研究进展[J]. 中医学, 2025, 14(4): 1541-1549. https://doi.org/10.12677/tcm.2025.144232

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