吲哚菁绿荧光影像技术在肝胆胰外科中的应用

Clinical Applications of Indocyanine Green Fluorescence Imaging in Hepatobiliary and Pancreatic Surgery

摘要: 吲哚菁绿(indocyaninegreen, ICG)荧光影像技术(Indocyaninegreen fluorescence image, ICG-FI)是由近红外光激发产生荧光的成像方式。本研究系统阐述了该技术的显像机制、给药方案及临床安全性。在肝脏外科领域，ICG-FI技术被广泛应用于肿瘤边界界定、肝功能储备检测、肝段染色定位及胆漏预防等方面；在胆道外科中，该技术为胆囊切除及肝内胆管癌手术提供了精确导航；在胰腺外科方面，其可有效协助病变定位及淋巴结清扫；同时，该技术可降低术后胆漏及肝功能衰竭的风险。通过结合三维重建技术，ICG-FI实现了肿瘤精确定位及周边血管胆管结构的清晰辨识，促进了手术方案的优化，推动了肝胆胰外科向微创化、精准化方向发展。

Abstract: Indocyanine green fluorescence imaging (ICG-FI) is an imaging modality that utilizes near-infrared light to excite fluorescence. This study systematically elucidates the imaging mechanism, administration protocols, and clinical safety of this technology. In the field of hepatic surgery, ICG-FI has been extensively applied for tumor boundary delineation, assessment of liver functional reserve, hepatic segment staining and localization, and bile leak prevention. In biliary surgery, the technique provides precise navigation for cholecystectomy and surgery for intrahepatic cholangiocarcinoma. In pancreatic surgery, it effectively assists in lesion localization and lymph node dissection. Additionally, ICG-FI reduces the risk of postoperative bile leaks and hepatic failure. By integrating three-dimensional reconstruction technology, ICG-FI enables precise tumor localization and clear identification of surrounding vascular and biliary structures, thereby facilitating the optimization of surgical strategies. This advancement propels hepatobiliary and pancreatic surgery toward minimally invasive and precision-oriented approaches.