维生素D治疗支气管肺发育不良的研究进展
Research Progress of Vitamin D in the Treatment of Bronchopulmonary Dysplasia
DOI: 10.12677/acm.2025.1541305, PDF,   
作者: 张莉欣：重庆医学大学附属儿童医院新生儿科，重庆；李 芳*：重庆医学大学附属儿童医院新生儿科，重庆；重庆医科大学附属妇女儿童医院儿科，重庆
关键词: 炎症与氧化应激；维生素D；早产儿；支气管肺发育不良；补充剂量；Inflammation and Oxidative Stress； Vitamin D； Preterm Infants； Bronchopulmonary Dysplasia； Supplemental Dose
摘要: 支气管肺发育不良(Bronchopulmonary Dysplasia, BPD)是早产儿常见肺部疾病，其主要特征包括肺损伤、炎症反应、氧化应激、肺血管异常以及肺发育受损。BPD的早期干预对于改善早产儿的预后具有重要意义。目前临床上主要采用咖啡因、利尿剂和糖皮质激素等药物进行治疗，但这些药物通常需在生后较晚阶段使用，且其安全性和长期效果仍存争议。近年来，维生素D因其良好的安全性、低成本和广泛的生理作用，成为BPD治疗的潜在新选择。越来越多的研究表明，早期应用维生素D可能有助于改善BPD的病理进程，提高治疗效果。本文将对维生素D在BPD治疗中的研究进展进行综述，以期为临床实践提供参考。
Abstract: Bronchopulmonary dysplasia (BPD) is a common lung disease in preterm infants, characterized mainly by lung injury, inflammatory response, oxidative stress, lung vascular abnormalities, and impaired lung development. Early intervention for BPD is of great significance for improving the prognosis of preterm infants. Currently, caffeine, diuretics, and glucocorticoids are primarily used in clinical settings, but their use is often delayed and their long-term safety is debated. In recent years, vitamin D has emerged as a potential new treatment for BPD due to its good safety profile, low cost, and wide-ranging physiological effects. An increasing number of studies suggest that early vitamin D use may improve the disease process and treatment outcomes of BPD. This article reviews the research progress of vitamin D in BPD treatment to inform clinical practice.
文章引用：张莉欣, 李芳. 维生素D治疗支气管肺发育不良的研究进展[J]. 临床医学进展, 2025, 15(4): 3349-3356. https://doi.org/10.12677/acm.2025.1541305

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