TERT启动子突变和膀胱癌临床病理特征关系的Meta分析

Association Between TERT Promoter Mutations and Clinicopathological Characteristics in Bladder Cancer: A Meta-Analysis

摘要: 目的：采用Meta分析评价TERT启动子突变和膀胱癌临床病理特征的关系。方法：检索Cochrane Library、Embase、PubMed、Web of Science、万方全文数据库、中国知网数据库，搜索与TERT启动子突变相关的膀胱癌的病例对照研究，检索截至2024年11月。两名研究人员独立筛选文献、提取信息、整理数据、评估纳入研究的偏倚风险，然后使用Review Manager 5.3进行汇总分析。结果：经数据库检索后，共检索到1575篇文献，排除综述论文、会议论文和无关研究等文献后，最终共纳入8篇文献，共1130例患者。Meta分析结果表明，TERT启动子突变与性别之间存在关联，男性患者比女性患者更易发生TERT启动子突变。结论：与女性膀胱癌患者相比，男性膀胱癌患者更容易出现TERT启动突变，这暗示了膀胱癌中存在与性别相关的潜在分子机制，为实验室和临床肿瘤研究提供了新的方向。

Abstract: Objective: To evaluate the relationship between TERT promoter mutations and clinical pathological features of bladder cancer using a Meta-analysis. Methods: We searched PubMed, the Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases for case-control studies on TERT promoter mutations in bladder cancer, with data up to November 2024. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies. Meta-analysis was conducted using Review Manager 5.3. Results: A total of 1575 studies were identified through database searches. After excluding review articles, conference papers, and irrelevant studies, 8 studies with a total of 1130 patients were included. The Meta-analysis results showed that TERT promoter mutations are somewhat related to gender, with males being more likely to have TERT promoter mutations than females. Conclusion: Male bladder cancer patients are more likely to experience TERT promoter mutations compared to female bladder cancer patients. This suggests the presence of gender-related potential molecular mechanisms in bladder cancer, providing new insights for laboratory and clinical cancer research.