臭氧自体血回输治疗带状疱疹顽固性瘙痒症
Ozone Autologous Blood Reinfusion Therapy for Intractable Pruritus of Herpes Zoster
DOI: 10.12677/acm.2025.1551474, PDF,   
作者: 马增全, 聂永帧:内蒙古医科大学附属肿瘤医院麻醉疼痛科,内蒙古 呼和浩特;程 芳:河北工程大学附属医院疼痛科,河北 邯郸
关键词: 带状疱疹疼痛瘙痒Herpes Zoster Pain Pruritus
摘要: 带状疱疹是水痘–疱疹病毒在人体免疫力低下时潜伏病毒被重新激活并引起明显疼痛或瘙痒,带状疱疹后疼痛是临床常见,但瘙痒不常见。带状疱疹后瘙痒对个人生活质量的影响不亚于疼痛,却容易被忽视。本研究是在临床工作中遇到的一例右颈胸部带状疱疹确诊后顽固性瘙痒为主要症状的病例。此患者瘙痒评分为10分(viisual analogue scale, VAS),夜间间断入眠3~4小时,病人极其痛苦,严重影响患者生活质量。试用多种治疗方法,效果不佳,而改用臭氧大自血疗法治疗取得良好效果。
Abstract: Herpes zoster is a condition where the varicella-zoster virus, which is latent in the body when immunity is low, is reactivated and causes significant pain or itching. Postherpetic neuralgia is a common clinical condition, but pruritus is less frequent. The impact of postherpetic pruritus on an individual’s quality of life is no less than that of pain, and it is easily overlooked. This study involved a case encountered in clinical practice where the main symptom was persistent pruritus after the diagnosis of herpes zoster on the right cervical and thoracic region. The patient’s pruritus score was 10 (visual analogue scale, VAS), and they experienced intermittent sleep disruption for 3~4 hours at night. The patient was extremely distressed and the quality of life was severely affected. Various treatment methods were attempted but with no satisfactory results. Instead, ozone autologous blood therapy was adopted and achieved good therapeutic effects.
文章引用:马增全, 聂永帧, 程芳. 臭氧自体血回输治疗带状疱疹顽固性瘙痒症 [J]. 临床医学进展, 2025, 15(5): 1131-1134. https://doi.org/10.12677/acm.2025.1551474

参考文献

[1] 吴雪, 曹灵敏, 郑凯, 等. 三氧自体血回输联合脉冲射频治疗带状疱疹后神经痛临床观察[J]. 社区医学杂志, 2023, 21(17): 894-897+904.
[2] Warner, B.E., Goins, W.F., Kramer, P.R., et al. (2023) A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia, The Future of HIV-1 Therapeutics. Current Topics in Microbiology and Immunology, 438, 189-221.
[3] Park, C., John, H., Lee, J., Hong, S., Kim, M., Park, S., et al. (2022) The Relative Frequency of Pruritus in Postherpetic Neuralgia Patients Presenting to the Pain Clinic and Associative Factors. Medicine, 101, e30208. [Google Scholar] [CrossRef] [PubMed]
[4] 王慧敏, 葛少莉, 李芙蓉. 马斯洛需要层次论下综合干预对带状疱疹伴瘙痒患者疾病知识掌握和自我负担的影响[J]. 中国医药导报, 2022, 19(27): 178-181.
[5] Özdemir, M. and Tüzün, Y. (2004) Herpes Zoster and Pruritus. International Journal of Dermatology, 43, 779-780. [Google Scholar] [CrossRef] [PubMed]
[6] 杨勇旺, 周修琴. 普瑞巴林治疗带状疱疹后瘙痒的效果观察[J]. 海峡药学, 2020, 32(9): 136-137.
[7] 王晓旭, 吴波, 路永红, 等. 带状疱疹神经性瘙痒的中西医研究现状[J]. 北京中医药, 2020, 39(12): 1324-1327.
[8] Cattel, F., Giordano, S., Bertiond, C., Lupia, T., Corcione, S., Scaldaferri, M., et al. (2021) Ozone Therapy in COVID-19: A Narrative Review. Virus Research, 291, Article ID: 198207. [Google Scholar] [CrossRef] [PubMed]
[9] Oliveira Modena, D.A., de Castro Ferreira, R., Froes, P.M., et al. (2022) Ozone Therapy for Dermatological Conditions: A Systematic Review. The Journal of Clinical and Aesthetic Dermatology, 15, 65-73.
[10] Delgadillo-Valero, L.F., Hernández-Cruz, E.Y. and Pedraza-Chaverri, J. (2023) The Protective Role of Ozone Therapy in Kidney Disease: A Review. Life, 13, Article No. 752. [Google Scholar] [CrossRef] [PubMed]
[11] Liu, L., Zeng, L., Gao, L., Zeng, J. and Lu, J. (2022) Ozone Therapy for Skin Diseases: Cellular and Molecular Mechanisms. International Wound Journal, 20, 2376-2385. [Google Scholar] [CrossRef] [PubMed]
[12] 赵艳红, 李明泽, 王连松, 等. C2背根神经节脉冲射频联合三氧自体血疗法治疗老年颈源性头痛的效果[J]. 国际老年医学杂志, 2024, 45(1): 36-40.
[13] 吴巧兰, 李林, 李雯丽. 医用三氧自体血回输疗法在12例失眠患者治疗中的应用[J]. 实用临床护理学电子杂志, 2020, 5(21): 93.
[14] 李素荣, 陈翠荣, 杨杰, 等. 免疫三氧自体血回输对老年带状疱疹后神经痛发病率的影响[J]. 河北医药, 2018, 40(14): 2135-2138.
[15] He, S., Chen, W., Xia, J., Lai, Z., Yu, D., Yao, J., et al. (2020) Effects of Ozone Autohemotherapy on Blood VEGF, TGF-β and PDGF Levels after Finger Replantation. Annals of Palliative Medicine, 9, 3332-3339. [Google Scholar] [CrossRef] [PubMed]
[16] Anitua, E., Zalduendo, M.M., Troya, M. and Orive, G. (2014) Ozone Dosing Alters the Biological Potential and Therapeutic Outcomes of Plasma Rich in Growth Factors. Journal of Periodontal Research, 50, 240-247. [Google Scholar] [CrossRef] [PubMed]
[17] 陈楠, 冯鹿方, 李美萱, 等. 臭氧自体血回输疗法治疗带状疱疹后神经痛疗效的系统评价[J]. 中国医药导刊, 2021, 23(9): 641-646.
[18] Shen, W., Liu, N., Ji, Z., Fang, H., Liu, F., Zhang, W., et al. (2022) Combining Ozonated Autohemotherapy with Pharmacological Therapy for Comorbid Insomnia and Myofascial Pain Syndrome: A Prospective Randomized Controlled Study. Pain Research and Management, 2022, Article ID: 3562191. [Google Scholar] [CrossRef] [PubMed]
[19] 李晓亮, 李琰光, 叶向阳, 等. 三氧自体血疗法(间接静脉内方法)的临床研究进展[J]. 中国合理用药探索, 2023, 20(10): 23-31.