中医药调控NF-κB信号通路治疗银屑病的研究进展

Advances in the Regulation of NF-κB Signaling Pathway by Traditional Chinese Medicine in the Treatment of Psoriasis

摘要: 银屑病，是一种常见的慢性复发性炎症性皮肤病，具有病程较长、病因复杂，病情变化多端等特点。近年来，对银屑病的研究不断深入，发现NF-κB信号通路与其发生、发展密切相关。生物制剂的局限性，也让中医药展现出独特的特色与优势。本文通过整理发现单味中药及其有效成分和中药复方调控NF-κB信号通路治疗银屑病有明显的疗效，为中医药治疗银屑病提供新思路和理论参考。银屑病，又称为牛皮癣，古籍中称银屑病为“白疕”“蛇虱”等，银屑病是一种常见的慢性复发性炎症性皮肤病，其临床表现为上覆鳞屑、薄膜现象和点状出血现象，具有病程较长、病因复杂，病情变化多端等特点。据统计，我国银屑病患病率在持续上升，对患者的身体、心理、经济以及生存质量均造成了严重的影响，也给社会公共健康带来极大负担。近年来，生物制剂的广泛应用已展现出不错的治疗效果，但其品类单一、价格高昂，且注射给药不便使用，使其有一定的局限性。中医药历史悠久，其生物活性成分高、多靶点、副作用较少、价格相对低廉，在治疗免疫调节和自身免疫性疾病上有独特的特色与优势。银屑病与单味中药有效成分、中药复方具有分子靶点对应关系。因此，中医药调控不同的信号通路对于银屑病的治疗有重要意义。

Abstract: Psoriasis, as a common chronic recurrent inflammatory skin disease, has the characteristics of a long course of disease, complex etiology, and varied conditions. In recent years, the study of psoriasis has been deepening, and it has been found that NF-κB signaling pathway is closely related to its occurrence and development. The limitations of biological agents also make traditional Chinese medicine show its unique characteristics and advantages. In this paper, it was found that single Chinese medicine and its active components and Chinese medicine compound regulate NF-κB signaling pathway have an obvious curative effect in the treatment of psoriasis, which provides a new idea and theoretical reference for the treatment of psoriasis with Chinese medicine. Psoriasis, also known as psoriasis, is referred to as “white crust” and “snake lice” in ancient books, etc. Psoriasis is a common chronic recurrent inflammatory skin disease with clinical manifestations of overlying scales, thin films and punctated bleeding. It is characterized by a long course of disease, complex etiology and variable disease. According to statistics, the prevalence rate of psoriasis in China continues to rise, which has a serious impact on patients’ physical, psychological, economic and quality of life, and also brings a great burden to social and public health. In recent years, the wide application of biologics has shown good therapeutic effects, but their single category, high price, and inconvenient injection of drugs make them have certain limitations. Traditional Chinese medicine has a long history, with high bioactive ingredients, multiple targets, few side effects, and relatively low price. It also has unique characteristics and advantages in the treatment of immune regulation and autoimmune diseases. Psoriasis has the corresponding molecular target relationship with the effective components of single Chinese medicine and Chinese medicine compound. Therefore, the regulation of different signaling pathways by traditional Chinese medicine is of great significance for the treatment of psoriasis.