中医干预MicroRNA调控治疗特应性皮炎的研究进展
Research Progress of Chinese Medicine Intervention in MicroRNA Treatment of Atopic Dermatitis
DOI: 10.12677/jcpm.2025.43336, PDF,   
作者: 吴绍青：黑龙江中医药大学研究生院，黑龙江 哈尔滨；马天明*：黑龙江中医药大学附属第二医院皮肤科，黑龙江 哈尔滨
关键词: 特应性皮炎；MicroRNA；中药；Atopic Dermatitis； MicroRNA； Traditional Chinese Medicine
摘要: 特应性皮炎(AD)是一种病因复杂的慢性复发性炎症性皮肤病，表现为干燥、瘙痒、多形损害等，是临床上亟待解决的皮肤病。microRNA作为一种内源性非编码RNA，在与靶基因microRNA的3'非翻译区(3'UTR)结合后，抑制了靶基因翻译、促进其降解，使其转录后水平调控基因表达。研究表明，多种microRNA在特应性皮炎的发病过程中发挥重要作用，如miR-146a可通过调控炎症相关基因表达，影响特应性皮炎的炎症反应，miR-155则参与调节Th1/Th2细胞平衡，进而影响疾病进程。中药调控microRNA可以抑制白细胞介素6受体(IL-6R)和蛋白酶体β-8亚基(PSMB-8)进行免疫调节、阻断NF-κB信号通路、控制炎症因子分泌、抑制角质形成细胞增殖等改善AD病变。本文综述近年来中药干预microRNA调控治疗AD的研究进展，以期为中药治疗AD提供更新的策略。
Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with genetic hypersensitivity, characterized by pruritus, polymorphic lesion, and exudation tendency. microRNA is a non-coding single-stranded RNA molecule that participates in post-transcriptional gene expression regulation in animals and plants, and plays an important role in the occurrence and development of AD by affecting cell development, differentiation and signal transduction, thereby changing cell function and controlling the release of inflammatory mediators. Intervention in the regulation of microRNA may be a new direction for the treatment of AD. Chinese medicines can inhibit interleukin-6 receptor (IL-6R) and proteasome β by targeting microRNA regulation. The β-8 subunit (PSMB-8) is responsible for immune regulation, blocking NF-κB signaling pathway, controlling the secretion of inflammatory factors, inhibiting the proliferation of keratinocytes, regulating Th2 cytokine secretion and inflammatory cell infiltration, maintaining the skin barrier, and activating platelets. In this paper, we reviewed the recent research progress of Chinese medicine intervention in the treatment of AD by microRNA regulation, in order to provide updated strategies for the treatment of AD by Chinese medicine.
文章引用：吴绍青, 马天明. 中医干预MicroRNA调控治疗特应性皮炎的研究进展[J]. 临床个性化医学, 2025, 4(3): 217-222. https://doi.org/10.12677/jcpm.2025.43336

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