中医药调控生精细胞凋亡研究文献可视化分析

Visual Analysis of Research Literature on TCM Regulation of Spermatogenic Cell Apoptosis

摘要: 目的：分析中医药调控生精细胞凋亡领域的研究文献，了解该领域的研究现状和发展趋势。方法：以中国知网数据库为数据来源，检索建库至2024年7月31日收录的中医药调控生精细胞凋亡领域的研究文献。采用CiteSpace6.3.R1软件对研究作者、机构和关键词进行可视化分析。结果：纳入文献378篇，发文量整体呈阶梯式上升趋势；最高产的作者是张长城，形成以赵海霞、袁丁等作者为主的合作团队；全国中医药高校及其附属医院为核心发文机构，其中北京中医药大学是该领域发文量最多的研究机构；高频和高中心性关键词包括细胞凋亡、生精细胞、氧化应激、环磷酰胺等。结论：中医药调控生精细胞凋亡领域近年研究热度较高。实验研究、作用机制、病理生理、相关疾病和中医药干预为该领域研究热点。研究趋势以实验研究为基础，采用中医药干预的手段，探索中医药通过调控相关通路来调节生精细胞凋亡的具体分子机制，主要围绕自噬、氧化应激、生殖损伤等途径展开广泛研究。

Abstract: Objective: To analyze the research literature on the regulation of spermatogenic cell apoptosis by TCM, and to understand the research status and development trend in this field. Methods: Based on the data source of CNKI database, the research literature on the regulation of spermatogenic cell apoptosis by TCM from the establishment of the database to July 31, 2024 was retrieved. The study utilized CiteSpace6.3.R1 to perform visual analysis of authors, institutions, and keywords. Results: A total of 378 articles were included, and the overall number of publications showed a stepwise upward trend; The author of the highest yield is Zhang Changcheng, forming a cooperative team mainly composed of Zhao Haixia, Yuan Ding and other authors; The national TCM universities and their affiliated hospitals were the core publishing institutions, among which Beijing University of Chinese Medicine was the research institution with the largest number of publications in this field; High-frequency and high-center keywords include apoptosis, spermatogenic cells, oxidative stress, cyclophosphamide, etc. Conclusion: In recent years, the research on the regulation of spermatogenic cell apoptosis by TCM has been hot. Experimental research, mechanism of action, pathophysiology, related diseases and traditional Chinese medicine intervention are the research hotspots in this field. Research trend based on the experimental research, the intervention of traditional Chinese medicine was used to explore the specific molecular mechanism of Chinese medicine in regulating the apoptosis of spermatogenic cells by regulating related pathways, mainly focusing on autophagy, oxidative stress, reproductive damage and other ways to carry out extensive research.