中西医结合治疗狼疮性肾炎研究进展

Research Progress on Integrated Traditional Chinese and Western Medicine Treatment of Lupus Nephritis

摘要: 系统性红斑狼疮是一种累及多个系统的自身免疫性疾病，其主要病理机制涉及为自身抗体介导的免疫复合物沉积。狼疮性肾炎作为系统性红斑狼疮最严重的并发症之一，临床统计约50%~65%的系统性红斑狼疮患者会出现肾脏损害，这不仅成为继发性肾小球肾炎的首要诱因，更显著提升了患者的终末期肾病的发生率及整体预后风险。现代医学常规方案多采用糖皮质激素联合免疫抑制剂为主，近年虽引入生物制剂进行干预，但存在总体疗效不尽理想。传统西医治疗方法虽然能快速控制病情，但长期使用可能引发多种药物相关不良反应，且病情反复，临床症候改善不显著等不足之处。现代研究中西医结合诊疗方案具有独特优势，可起到减毒增效的作用，本文对近年来中西医治疗狼疮性肾炎的相关研究文献进行综述，旨在为临床防治狼疮性肾炎提供理论基础和新思路。

Abstract: Systemic lupus erythematosus is an autoimmune disease involving multiple systems, and its main pathological mechanism involves the deposition of immune complexes mediated by autoantibodies. Lupus nephritis, as one of the most serious complications of Systemic lupus erythematosus, is clinically estimated to cause kidney damage in approximately 50%~65% of Systemic lupus erythematosus patients. This not only becomes the primary cause of secondary glomerulonephritis, but also significantly increases the incidence and overall prognostic risk of end-stage renal disease in patients. Modern medical conventional protocols mainly use glucocorticoids combined with immunosuppressants. Although biological agents have been introduced for intervention in recent years, the overall efficacy is not ideal. Although traditional Western medicine treatment methods can quickly control the condition, long-term use may cause multiple drug-related adverse reactions, and the condition may recur, with insignificant improvement in clinical symptoms. The modern research on integrated diagnosis and treatment of traditional Chinese and Western medicine has unique advantages, which can play a role in reducing toxicity and increasing efficiency. This article reviews the relevant research literature on the treatment of lupus nephritis with traditional Chinese and Western medicine in recent years, aiming to provide theoretical basis and new ideas for the clinical prevention and treatment of lupus nephritis.