血府逐瘀胶囊联合低分子肝素钠在中低危肺栓塞患者中的应用效果

The Effect of XueFuZhuYu Capsule Combined with Low Molecular Heparin Sodium in Patients with Low to Medium Risk Pulmonary Embolism

摘要: 目的：观察血府逐瘀胶囊联合低分子肝素钠在中低危肺栓塞病的临床效果。方法：选取2024年1月至2025年1月山东第一医科大学第二附属医院收治的急性肺栓塞患者60例，根据治疗方法不同分为观察组(血府逐瘀胶囊联合低分子肝素钠)和对照组(低分子肝素钠)各30例。比较两组的中医症候积分、治疗效果、心率、氧饱和度、D二聚体、血气分析氧分压及氨基末端脑钠肽前体。结果：治疗2周后，观察组中医症候咳嗽、咳痰、喘息、鼻塞、流清涕积分明显缓解，观察组各项指标优于对照组，差异有统计学意义(P < 0.05)，发热证候均治愈，治疗后两组无统计学差异(P > 0.05)。两组临床疗效指数比较，观察组治疗总有效率为96.67% (29/30)，明显高于对照组的73.33% (28/30)，差异有统计学意义(P < 0.05)。治疗后两组心率、氧饱和度、D二聚体、SpO₂及NT-proBNP水平明显低于治疗前，差异有统计学意义(P < 0.05)，且观察组低于对照组，差异有统计学意义(P < 0.05)。结论：血府逐瘀胶囊联合低分子肝素钠效果显著，可促使肺栓塞患者症状缓解、利于心肺功能恢复。

Abstract: Objective: to observe the clinical effect of XueFuZhuYu capsule combined with low molecular heparin sodium in medium and low risk pulmonary embolism disease. Methods: 60 patients with acute pulmonary embolism admitted to the Second Affiliated Hospital of Shandong First Medical University from January 2024 to January 2025 were selected and divided into 30 cases each in the observation group (haemofoo by blood stasis capsule combined with low molecular heparin sodium) and the control group (low molecular heparin sodium) according to the different treatment methods. The TCM symptom score, treatment effect, heart rate, oxygen saturation, D-dimer, oxygen partial pressure of blood gas analysis and amino-terminal brain natriuretic peptide precursor were compared between the two groups. RESULTS: After 2 weeks of treatment, the Chinese medicine symptoms of cough, cough sputum, wheezing, nasal congestion and running nose were significantly relieved in the observation group, and the indicators of the observation group were better than those of the control group, with statistically significant differences (P < 0.05), and the fever symptoms were cured, and there was no statistically significant difference between the two groups after treatment (P > 0.05). Comparing the clinical efficacy index of the two groups, the total effective rate of treatment in the observation group was 96.67% (29/30), which was significantly higher than that of the control group (73.33%) (28/30), and the difference was statistically significant (P < 0.05). The heart rate, oxygen saturation, D-dimer, SpO₂ and NT-proBNP levels of the two groups were significantly lower than those before treatment, and the difference was statistically significant (P < 0.05), and the observation group was lower than the control group, and the difference was statistically significant (P < 0.05). Conclusion XueFuZhuYu capsule combined with low molecular heparin sodium is effective, which can promote the alleviation of symptoms and facilitate the recovery of cardiopulmonary function in patients with pulmonary embolism.