卵圆孔未闭与不明原因晕厥及癫痫的关联机制和干预策略
The Association Mechanism and Intervention Strategies between Patent Foramen Ovale and Unexplained Syncope and Epilepsy
DOI: 10.12677/acm.2025.1582269, PDF,   
作者: 成嘉翔：延安大学延安医学院，陕西 延安；张义和：延安大学附属医院心脏血管医学中心，陕西 延安
关键词: 卵圆孔未闭；不明原因晕厥；癫痫；反常栓塞；封堵术；Patent Foramen Ovale； Unexplained Syncope； Epilepsy； Paradoxical Embolism；Occlusion Procedure
摘要: 卵圆孔未闭(PFO)作为临床上一种常见的先天性心脏结构异常，其在成年人中的发病率达20%~30%。已经有大量临床研究证实PFO与偏头痛、隐源性卒中、减压病、阻塞性睡眠呼吸暂停低通气综合征等疾病存在关联，近年来随着研究进一步深入，PFO疾病谱扩展至不明原因晕厥、癫痫等神经精神系统疾病，但病因及发病机制未完全明确。本文系统综述PFO与不明原因晕厥、癫痫的流行病学关联、潜在机制及干预效果，为临床上PFO合并不明原因晕厥、癫痫患者的诊断和治疗提供新的思路。
Abstract: Patent foramen ovale (PFO), as a common congenital cardiac structural abnormality in clinical practice, has an incidence rate of 20% to 30% among adults. A large number of clinical studies have confirmed that PFO is associated with diseases such as migraine, cryptogenic stroke, decompression sickness, and obstructive sleep apnea-hypopnea syndrome. In recent years, with further in-depth research, the disease spectrum of PFO has expanded to include neuropsychiatric disorders such as unexplained syncope and epilepsy, but the etiology and pathogenesis have not been fully clarified. This article systematically reviews the epidemiological association, potential mechanisms and intervention effects between PFO and syncope of unknown cause and epilepsy, providing new ideas for the diagnosis and treatment of patients with PFO combined with syncope of unknown cause and epilepsy in clinical practice.
文章引用：成嘉翔, 张义和. 卵圆孔未闭与不明原因晕厥及癫痫的关联机制和干预策略[J]. 临床医学进展, 2025, 15(8): 577-583. https://doi.org/10.12677/acm.2025.1582269

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