OSCC组织中PDGF-BB蛋白的表达与患者临床病理特征的关系

The Relationship between the Expression of PDGF-BB Protein in OSCC Tissue and the Clinical Pathological Characteristics of Patients

摘要: 目的：探讨口腔鳞状细胞癌(Oral Squamous Cell Carcinoma, OSCC)组织中血小板衍生生长因子-BB (Platelet-Derived Growth Factor-BB, PDGF-BB)蛋白的表达情况与患者临床病理特征的关系。方法：收集2020年6月至2025年6月在我科住院经病理组织学检查诊断为OSCC患者的相关临床资料及石蜡组织标本共126例，采用免疫组织化学染色检测OSCC组织中PDGF-BB蛋白的表达情况，并分析其与患者临床病理特征的相关性。结果：OSCC组织中PDGF-BB蛋白的阳性表达率为77.0% (97/126)，显著高于癌旁正常组织13.3% (4/30)，差异有统计学意义(P < 0.05)；PDGF-BB蛋白的表达与OSCC肿瘤T分期(肿瘤直径)、颈部淋巴结转移以及远处脏器转移相关(P < 0.05)，而与患者的年龄、性别、肿瘤部位及组织分化程度无关(P > 0.05)。结论：PDGF-BB蛋白在OSCC组织中呈高表达，其表达与肿瘤T分期、颈部淋巴结转移及远处脏器转移密切相关，可能是评估OSCC患者预后的潜在生物学标志物。

Abstract: Objective: To investigate the relationship between the expression of platelet-derived growth factor-BB (PDGF-BB) protein in oral squamous cell carcinoma (OSCC) tissues and the clinicopathological characteristics of patients. Methods: Clinical data and tumor tissue specimens from 126 patients diagnosed with OSCC by histopathological examination in our department from June 2020 to June 2025 were collected. Immunohistochemical staining was used to detect the expression of PDGF-BB protein in OSCC tissues, and its correlation with clinicopathological features was analyzed. Results: The positive expression rate of PDGF-BB protein in OSCC tissues was 77.0% (97/126), significantly higher than that in adjacent normal tissues (13.3%, 4/30), with a statistically significant difference (P < 0.05). The expression of PDGF-BB protein was correlated with OSCC T stage (tumor diameter), cervical lymph node metastasis, and distant organ metastasis (P < 0.05), but not with age, gender, tumor location, or degree of tissue differentiation (P > 0.05). Conclusion: PDGF-BB protein is highly expressed in OSCC tissues, and its expression is closely related to tumor T stage, cervical lymph node metastasis, and distant organ metastasis. It may serve as a potential biological marker for evaluating the prognosis of OSCC patients.