腹腔镜全子宫切除术的快速康复外科多模式镇痛管理
Rapid Recovery Surgical Multimodal Pain Management for Laparoscopic Hysterectomy
摘要: 腹腔镜全子宫切除术具有创伤小、恢复快等优点,是治疗女性生殖系统疾病的主要术式,但其术后仍存在明显疼痛,增加了不良反应发生率,影响手术效果及预后。多模式疼痛管理是加速康复外科中的关键环节,通过多种镇痛方式和不同机制镇痛药物的协同治疗,达到个体化用药,镇痛效果确切,减少患者应激反应,减少阿片类药物的用药剂量,最大幅度地降低不良反应,促进患者术后快速康复。本文总结了腹腔镜子宫切除术多模式镇痛管理的相关进展以及未来的趋势,以期实现更安全、高效、精准化、人性化的围术期疼痛管理,推动腹腔镜子宫切除术多模式镇痛发展,给广大患者带来满意的麻醉体验。
Abstract: Laparoscopic hysterectomy has the advantages of minimal trauma and rapid recovery, making it a primary surgical procedure for treating female reproductive system diseases. However, significant postoperative pain can still occur, increasing the incidence of adverse reactions and affecting surgical effectiveness and prognosis. Multimodal pain management is a key component of enhanced recovery after surgery. By combining multiple analgesic modalities and analgesics with different mechanisms, it achieves personalized medication, precise analgesic efficacy, reduced patient stress response, reduced opioid dosage, minimized adverse reactions, and promoted rapid postoperative recovery. This article summarizes the progress and future trends in multimodal analgesia management for laparoscopic hysterectomy, aiming to achieve safer, more efficient, precise, and user-friendly perioperative pain management, promote the development of multimodal analgesia for laparoscopic hysterectomy, and provide patients with a satisfactory anesthesia experience.
文章引用:王银顺, 黎娟娟, 黄明艺, 施乐邦, 杨毅. 腹腔镜全子宫切除术的快速康复外科多模式镇痛管理[J]. 临床医学进展, 2025, 15(9): 975-983. https://doi.org/10.12677/acm.2025.1592582

参考文献

[1] 肖锐. 不同气腹压力联合不同神经肌肉阻滞深度对老年RARP患者术后肾功能的影响[D]: [硕士学位论文]. 长沙: 中南大学, 2022.
[2] Muallem, M.Z., Dimitrova, D., Pietzner, K., et al. (2016) Implementation of Enhanced Recovery After Surgery (ERAS) Pathways in Gynecologic Oncology. A NOGGO-AGO Survey of 144 Gynecological Departments in Germany. Anticancer Research, 36, 4227-4232.
[3] 张努, 徐连生. 右美托咪定联合利多卡因静脉输注对腹腔镜全子宫切除术患者氧化应激水平及炎性反应的影响[J]. 中国医药导报, 2018, 15(10): 95-98+134.
[4] Mian, M.U., Afzal, M., Butt, A.A., Ijaz, M., Khalil, K., Abbasi, M., et al. (2024) Neuropharmacology of Neuropathic Pain: A Systematic Review. Cureus, 16, e69028. [Google Scholar] [CrossRef] [PubMed]
[5] Krishnan, M., Narice, B., Cheong, Y.C., Lumsden, M.A., Daniels, J.P., Hickey, M., et al. (2024) Surgery and Minimally Invasive Treatments for Uterine Fibroids. Cochrane Database of Systematic Reviews, No. 6, CD015650. [Google Scholar] [CrossRef] [PubMed]
[6] 田晓涛, 张宪宦, 韩景田, 等. 超声引导下胸椎旁神经阻滞在食管癌全麻患者术中应激状况及苏醒质量的影响[J]. 贵州医药, 2018, 42(12): 1458-1460.
[7] Clarke, H., Poon, M., Weinrib, A., Katznelson, R., Wentlandt, K. and Katz, J. (2015) Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain. Drugs, 75, 339-351. [Google Scholar] [CrossRef] [PubMed]
[8] Kehlet, H. (1997) Multimodal Approach to Control Postoperative Pathophysiology and Rehabilitation. British Journal of Anaesthesia, 78, 606-617. [Google Scholar] [CrossRef] [PubMed]
[9] Mathiesen, O., Dahl, B., Thomsen, B.A., Kitter, B., Sonne, N., Dahl, J.B., et al. (2013) A Comprehensive Multimodal Pain Treatment Reduces Opioid Consumption after Multilevel Spine Surgery. European Spine Journal, 22, 2089-2096. [Google Scholar] [CrossRef] [PubMed]
[10] 张静, 夏瑜, 陆希, 等. 加速康复外科模式下妇科良性疾病腹腔镜手术多模式镇痛与传统镇痛方案效果比较研究[J]. 中国实用妇科与产科杂志, 2024, 40(6): 657-660.
[11] 李秋红, 徐铭军. 妇科手术患者围手术期镇痛药物及方法的应用进展[J]. 山东医药, 2017, 57(3): 104-106.
[12] Jin, Z., Zhu, M., Gupta, A., Page, C., Gan, T.J. and Bergese, S.D. (2022) Evaluating Oliceridine as a Treatment Option for Moderate to Severe Acute Post-Operative Pain in Adults. Expert Opinion on Pharmacotherapy, 23, 9-17. [Google Scholar] [CrossRef] [PubMed]
[13] 余剑鹏, 刘颖, 陈诗怡, 等. 奥赛利定的临床应用进展[J]. 实用药物与临床, 2025, 28(2): 156-160.
[14] Ibrahim, A.M., Obaidi, Z., Ruan, G., Adaramola, D. and Onguti, S. (2018) Nalbuphine for Opioid-Induced Urine Retention. Annals of Internal Medicine, 169, 894-895. [Google Scholar] [CrossRef] [PubMed]
[15] 杨青青, 胡宪文, 李云, 等. 不同剂量纳布啡复合舒芬太尼用于腹腔镜全子宫切除术后患者自控静脉镇痛的效果[J]. 临床麻醉学杂志, 2020, 36(2): 140-143.
[16] 段函宇, 刘子嘉, 许广艳, 等. 胸腔镜肺叶切除术的快速康复外科多模式镇痛管理[J]. 中国医学科学院学报, 2021, 43(1): 136-143.
[17] 刘晴, 李晓东, 覃旺军, 等. 选择性COX-2抑制剂用于髋/膝关节置换术超前镇痛有效性及安全性的Meta分析[J]. 中国药房, 2022, 33(19): 2409-2413.
[18] Batchelor, T.J.P., Rasburn, N.J., Abdelnour-Berchtold, E., Brunelli, A., Cerfolio, R.J., Gonzalez, M., et al. (2019) Guidelines for Enhanced Recovery after Lung Surgery: Recommendations of the Enhanced Recovery after Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS). European Journal of Cardio-Thoracic Surgery, 55, 91-115. [Google Scholar] [CrossRef] [PubMed]
[19] 纪丹丹, 朱萍莉. 氟比洛芬酯超前镇痛对腹腔镜子宫切除术患者疼痛介质水平及免疫抑制的影响[J]. 中国计划生育学杂志, 2023, 31(6): 1326-1330.
[20] Harrer, S., Yayac, M., White, P.B., Toci, G.R., Levicoff, E., Courtney, P.M., et al. (2024) Efficacy of Liposomal Bupivacaine Versus a Traditional Local Anesthetic in Periarticular Injections during Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. Journal of Surgical Orthopaedic Advances, 33, 143-151. [Google Scholar] [CrossRef
[21] 陈军, 张南南, 张帆, 等. 布比卡因脂质体腹横肌平面阻滞在腹腔镜妇科手术镇痛中的应用效果观察[J]. 山东医药, 2024, 64(29): 34-38.
[22] 艾司氯胺酮临床应用专家指导意见专家组, 严敏. 艾司氯胺酮临床应用专家指导意见[J]. 国际麻醉学与复苏杂志, 2023, 44(8): 785-793.
[23] 徐慧, 解成兰, 王艺倩, 等. 不同剂量艾司氯胺酮对腹腔镜全子宫切除术患者术后疼痛和情绪状态的影响[J]. 现代生物医学进展, 2024, 24(6): 1176-1181.
[24] 吴瑶, 李亚玲, 李建长. 右美托咪定对全身麻醉下腹腔镜子宫切除术中血流动力学及应激反应的影响[J]. 临床和实验医学杂志, 2020, 19(10): 1108-1113.
[25] 范冬燕, 庄新元. 帕瑞昔布钠术前给药对腹腔镜子宫切除术后患者应激反应及血清miR-150、miR-155表达的影响[J]. 中国计划生育学杂志, 2020, 28(2): 198-202.
[26] Benabou, K., Kim, S., Tierney, C.H., Messom, J.E., Kyriakides, T.C., Kashani, S.M., et al. (2020) Laparoscopic Posterior versus Lateral Transversus Abdominis Plane Block in Gynecology. JSLS: Journal of the Society of Laparoscopic & Robotic Surgeons, 24, e2020.00032. [Google Scholar] [CrossRef] [PubMed]
[27] 汪伟, 程勤耘, 杜伏杨, 等. 剖宫产术后地塞米松、右美托咪定复合罗哌卡因行腹横肌平面阻滞镇痛效果[J]. 中国计划生育学杂志, 2024, 32(7): 1513-1518.
[28] 朱礼耀, 陈萌萌. 超声引导下腹横肌平面阻滞麻醉对腹腔镜子宫切除术患者术后镇痛的效果及早期康复的影响[J]. 现代医学与健康研究电子杂志, 2024, 8(2): 62-65.
[29] 王丽, 自华芬. 超声引导下后路腰方肌阻滞对腹腔镜子宫切除术患者应激水平和微循环影响[J]. 中国计划生育学杂志, 2022, 30(1): 55-59.
[30] 刘祥波, 欧册华, 母国. 腰方肌阻滞与腹横肌平面阻滞用于成人腹部手术术后镇痛效果的Meta分析[J]. 临床麻醉学杂志, 2020, 36(7): 677-684.
[31] 谭佳. 腹横肌平面阻滞与腰方肌阻滞用于腹部手术术后镇痛的应用比较[D]: [硕士学位论文]. 广州: 南方医科大学, 2020.
[32] 张春梅, 张江川, 陈运良, 等. 超声引导下腰方肌后路阻滞联合全身麻醉在腹腔镜全子宫切除术中的应用效果[J]. 中国计划生育学杂志, 2025, 33(4): 792-798.
[33] 周桂云, 杨小林, 任映梅, 等. 弓状韧带上腰方肌阻滞对妇科腹腔镜全子宫切除术后镇痛的影响[J]. 临床麻醉学杂志, 2024, 40(4): 389-392.
[34] 余高锋, 金尚怡, 李会仁, 等. 腰方肌阻滞在剖宫产术后镇痛的效果评估[J]. 实用医学杂志, 2018, 34(15): 2567-2570.
[35] Sugihara, M., Miyake, T., Miyagi, Y., Oda, T., Hazama, Y., Sano, R., et al. (2018) Does Local Infiltration Anesthesia on Laparoscopic Surgical Wounds Reduce Postoperative Pain? Randomized Control Study. Reproductive Medicine and Biology, 17, 474-480. [Google Scholar] [CrossRef] [PubMed]
[36] Frost, A.S., Kohn, J.R., Le Neveu, M., Brah, T., Okonkwo, O., Borahay, M.A., et al. (2023) Laparoscopic Administration of Bupivacaine at the Uterosacral Ligaments during Benign Laparoscopic and Robotic Hysterectomy: A Randomized Controlled Trial. American Journal of Obstetrics and Gynecology, 229, 526.e1-526.e14. [Google Scholar] [CrossRef] [PubMed]
[37] Simpson, J., Bao, X. and Agarwala, A. (2019) Pain Management in Enhanced Recovery after Surgery (ERAS) Protocols. Clinics in Colon and Rectal Surgery, 32, 121-128. [Google Scholar] [CrossRef] [PubMed]
[38] Samer, C.F., Desmeules, J.A. and Dayer, P. (2006) Individualizing Analgesic Prescription Part I: Pharmacogenetics of Opioid Analgesics. Personalized Medicine, 3, 239-269. [Google Scholar] [CrossRef] [PubMed]
[39] 中华医学会麻醉学分会“智能化病人自控镇痛管理专家共识”工作小组, 熊利泽. 智能化病人自控镇痛管理专家共识[J]. 中华麻醉学杂志, 2018, 38(10): 1161-1165.
[40] 王建东, 胡强夫, 郑鹏远, 等. 智能化自控静脉镇痛在老年患者腹腔镜结直肠癌根治术后应用的效果[J]. 临床麻醉学杂志, 2022, 38(4): 341-345.