TCT联合HPV及宫颈刮片在宫颈癌及癌前病变筛查的应用研究

Application of TCT Combined with HPV and Cervical Scraping in Screening for Cervical Cancer and Precancerous Lesions

摘要: 目的：主要针对宫颈癌及癌前病变筛查中HPV检测、TCT及宫颈刮片的应用效果进行研究。方法：选择我院体检中心2020年5月~2022年4月期间体检人群16,472例进行回顾性分析，其中4108例选择HPV筛查，本文选择350例病理学检查阳性人群，对TCT联合HPV筛查以及宫颈刮片检查进行分析，了解检查情况以及检出率。结果：HPV + TCT检测阳性检出率为96.86%，高于宫颈刮片57.43%，存在统计学意义P < 0.05的差异。浸润癌的HPV + TCT检测、CIN I、CIN II、CIN III，浸润癌的检出率和高度病变的检出率分别为(95.23%, 97.65%, 96.19%, 98.19%, 98.27%)，均高于宫颈刮片(52.38%, 47.06%, 57.14%, 70.65%, 60.55%)，相差显著，P < 0.05。结论：宫颈癌及癌前病变筛查采用HPV + TCT检测可获得理想效果，提高诊断效率。

Abstract: The purpose of this study is to investigate the application effects of HPV testing, TCT, and cervical scraping in the screening of cervical cancer and precancerous lesions. Method: A retrospective analysis was conducted on 16,472 individuals who underwent physical examinations at our hospital’s physical examination center from May 2020 to April 2022. Among them, 4108 individuals underwent HPV screening, and 350 individuals who tested positive underwent pathological examination and were selected for TCT combined with HPV screening and cervical scraping examination to understand the examination results and detection rates. Result: The positive detection rate of HPV + CT was 96.86%, which was higher than that of cervical scraping at 57.43%, with a statistically significant difference of P < 0.05. The detection rates of HPV + TCT for invasive cancer, CIN I, CIN II, CIN III, invasive cancer, and highly pathological lesions were 95.23%, 97.65%, 96.19%, 98.19%, and 98.27%, respectively, which were significantly higher than those of cervical scraping (52.38%, 47.06%, 57.14%, 70.65%, and 60.55%), P < 0.05. Conclusion: HPV + TCT testing can achieve ideal results and improve diagnostic efficiency in screening cervical cancer and precancerous lesions.