基于络病理论探讨康复新液对宫腔粘连的影响

Discussion on the Influence of Kangfuxin Liquid on Intrauterine Adhesion Based on the Collateral Disease Theory

摘要: 本研究以络病理论为核心，系统探讨康复新液干预宫腔粘连的作用机制及其中西医结合理论基础。宫腔粘连因手术创伤、感染等因素导致病程迁延，符合中医“久病入络”、“络脉瘀阻”的病理特征，其核心病机为络脉瘀阻与胞宫胞脉损伤的恶性循环。康复新液作为通利血脉、养阴生肌的中药制剂，在宫腔粘连病理进程中通过多途径发挥作用：1) 促进血管内皮生长因子(VEGF)分泌，改善胞宫微循环并诱导血管新生；2) 降低肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)等炎性细胞因子水平，减轻炎症反应；3) 抑制转化生长因子-β1 (TGF-β1)/Smads信号通路激活，抑制纤维化并调控细胞增殖分化。上述作用共同促进受损络脉的结构性修复与功能性重建。本综述为临床应用康复新液防治宫腔粘连提供理论依据，并展望其与现代医学结合的研究方向，以期为中西医结合治疗开拓新思路。

Abstract: This study takes the Collateral Disease Theory as its core to systematically explore the mechanisms of Kangfuxin Liquid in intervening with intrauterine adhesion (IUA) and its theoretical basis for integrating traditional Chinese and Western medicine. IUA, caused by factors such as surgical trauma and infection, leads to a prolonged course of disease, which aligns with the pathological characteristics of “chronic disease invading collaterals” and “collateral blood stasis” in traditional Chinese medicine (TCM). Its core pathogenesis is a vicious cycle of collateral blood stasis and damage to the uterine collaterals. As a TCM preparation with the effects of unblocking collateral circulation and nourishing yin to promote tissue regeneration, Kangfuxin Liquid exerts its effects through multiple pathways in the pathological process of IUA: 1) Promoting the secretion of vascular endothelial growth factor (VEGF) to improve uterine microcirculation and induce angiogenesis; 2) Reducing the levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) to alleviate inflammatory responses; 3) Inhibiting the activation of the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway to suppress fibrosis and regulate cell proliferation and differentiation. These combined effects promote the structural repair and functional reconstruction of damaged collaterals. This review provides a theoretical basis for the clinical application of Kangfuxin Liquid in the prevention and treatment of IUA and prospects its research directions in combination with modern medicine, aiming to open new avenues for integrative medicine therapy.