腹腔镜阑尾切除术的研究现状与进展
Research Status and Progress of Laparoscopic Appendectomy
摘要: 腹腔镜阑尾切除术(Laparoscopic appendectomy, LA)作为一种微创手术方式,较传统开腹阑尾切除术(Open appendectomy, OA)具有创伤小、术后恢复快等优势。随着设备与技术的不断进步,LA已成为急性阑尾炎的主流治疗手段。然而,其在特殊病情(如阑尾周围脓肿、妊娠期阑尾炎等)、术式选择(如SILA、NOTES)、术后疼痛管理及成本效益等方面仍存在诸多争议与优化空间。本文旨在系统综述LA的研究现状与最新进展,重点剖析目前存在争议的临床问题,评估不同术式的真实效益,探讨快速康复外科(ERAS)理念及区域神经阻滞等疼痛管理新策略在LA中的应用,并提出未来研究方向与临床实践建议,以期为LA的规范化、个体化应用提供理论依据。
Abstract: Laparoscopic appendectomy (LA), as a minimally invasive surgical approach, offers advantages such as reduced trauma and faster postoperative recovery compared to traditional open appendectomy (OA). With the continuous advancement of equipment and techniques, LA has become the mainstream treatment for acute appendicitis. However, there remain numerous controversies and areas for optimization in special conditions (such as periappendiceal abscess, pregnancy-related appendicitis), surgical technique selection (such as single-incision LA, Natural Orifice Transluminal Endoscopic Surgery—NOTES), postoperative pain management, and cost-effectiveness. This article aims to systematically review the current research status and latest progress of LA, with a focus on analyzing currently controversial clinical issues, evaluating the true benefits of different surgical techniques, exploring the application of Enhanced Recovery after Surgery (ERAS) concepts and new pain management strategies such as regional nerve blockade in LA, and proposing future research directions and clinical practice recommendations. The goal is to provide a theoretical basis for the standardized and individualized application of LA.
文章引用:刘立民, 万柏江, 刘卓. 腹腔镜阑尾切除术的研究现状与进展[J]. 临床医学进展, 2025, 15(10): 2077-2087. https://doi.org/10.12677/acm.2025.15102986

参考文献

[1] Yu, M.C., Feng, Y.J., Wang, W., et al. (2017) Is Laparoscopic Appendectomy Feasible for Complicated Appendicitis? A Systematic Review and Meta-Analysis. International Journal of Surgery, 40, 187-197. [Google Scholar] [CrossRef] [PubMed]
[2] Kirkpatrick, J., Wang, Y., Greene, M., Armstrong, D., Srinivasa, S. and Koea, J. (2024) The Increasing Use of Minimally Invasive Surgery in Acute General Surgical Conditions: A Decade of Results from a National Data Set. Surgery, 175, 1205-1211. [Google Scholar] [CrossRef] [PubMed]
[3] Köckerling, F., Schug-Paß, C. and Grund, S. (2009) Laparoskopische Appendektomie. Der Chirurg, 80, 594-601. [Google Scholar] [CrossRef] [PubMed]
[4] 段立纪, 王存川, 陈鋆. 腹腔镜阑尾切除术安全性的Meta分析[J]. 中国内镜杂志, 2001, 7(6): 18-20.
[5] Shiihara, M., Sudo, Y., Matsushita, N., Kubota, T., Hibi, Y., Osugi, H., et al. (2023) Therapeutic Strategy for Acute Appendicitis Based on Laparoscopic Surgery. BMC Surgery, 23, Article No. 161. [Google Scholar] [CrossRef] [PubMed]
[6] 郑宗珩, 魏波, 陈图锋, 等. 腹腔镜阑尾切除与开腹阑尾切除术的对比研究及Meta分析[J]. 中华普通外科学文献(电子版), 2009, 3(5): 438-442.
[7] Arang, H. and El Boghdady, M. (2023) Robotic Appendicectomy. Sultan Qaboos University Medical Journal, 23, 440-446. [Google Scholar] [CrossRef] [PubMed]
[8] 阿合提别克·塔布斯, 周军, 李剑辉, 等. 腹腔镜探查并阑尾切除术治疗异位阑尾炎19例临床分析[J]. 国际外科学杂志, 2015, 42(7): 460-462.
[9] 刘强, 杨峥. 急性阑尾炎肥胖患者腹腔镜与开腹手术的对比研究[J]. 中国微创外科杂志, 2014(10): 903-905.
[10] 孔韦奇, 陈中皓, 胡月梅, 等. 急性阑尾炎腹腔镜阑尾切除术后病理诊断为阑尾憩室炎一例[J]. 临床外科杂志, 2022, 30(6): 559-560.
[11] 王生, 朱委, 王威, 等. 坏疽性阑尾炎行腹腔镜手术的治疗体会[J]. 腹腔镜外科杂志, 2021, 26(12): 955-957.
[12] 黎朝良, 方兰, 黄建朋, 等. 腹腔镜阑尾切除术治疗腹部手术史急性阑尾炎的临床研究[J]. 国际外科学杂志, 2013, 40(7): 447-450.
[13] 彭靖, 王保臣, 王春, 等. 腹腔镜阑尾切除术中转开腹相关危险因素的分析[J]. 腹腔镜外科杂志, 2017, 22(9): 685-687.
[14] Erdem, V.M., Donmez, T., Uzman, S., Ferahman, S., Hatipoglu, E. and Sunamak, O. (2018) Spinal/Epidural Block as an Alternative to General Anesthesia for Laparoscopic Appendectomy: A Prospective Randomized Clinical Study. Videosurgery and Other Miniinvasive Techniques, 13, 148-156. [Google Scholar] [CrossRef] [PubMed]
[15] 李建桥, 文竹, 鲁鸿, 等. 不同麻醉方法对糖尿病患者阑尾切除术应激反应的影响[J]. 医学综述, 2013, 19(5): 940-941.
[16] 王绍廷. 腰硬联合麻醉和硬膜外麻醉在阑尾炎手术中应用效果对比[J]. 齐齐哈尔医学院学报, 2019, 40(1): 36-38.
[17] Basukala, S., Thapa, N., Bhusal, U., Shrestha, O., Karki, S., Regmi, S.K., et al. (2023) Comparison of Outcomes of Open and Laparoscopic Appendectomy: A Retrospective Cohort Study. Health Science Reports, 6, e1483. [Google Scholar] [CrossRef] [PubMed]
[18] 马洪新, 李桂华. 免气腹腹腔镜阑尾切除术、气腹腹腔镜阑尾切除术治疗老年阑尾炎的临床效果研究[J]. 中外医疗, 2023, 42(5): 50-53.
[19] Sartelli, M., Baiocchi, G.L., Di Saverio, S., et al. (2018) Prospective Observational Study on Acute Appendicitis Worldwide (POSAW). World Journal of Emergency Surgery, 13, Article No. 19.
[20] Schildberg, C., Weber, U., König, V., Linnartz, M., Heisler, S., Hafkesbrink, J., et al. (2025) Laparoscopic Appendectomy as the Gold Standard: What Role Remains for Open Surgery, Conversion, and Disease Severity? World Journal of Emergency Surgery, 20, Article No. 53. [Google Scholar] [CrossRef] [PubMed]
[21] 孙静秋, 朱从元, 王珂, 等. 三种不同戳孔入路在腹腔镜阑尾切除术中的对比研究[J]. 临床外科杂志, 2019, 27(12): 1037-1040.
[22] 李海军, 王举, 顾新, 等. 阑尾残端荷包缝合处理在两孔腹腔镜阑尾切除术的应用研究[J]. 内蒙古医科大学学报, 2022, 44(4): 383-385+388.
[23] 祁海燕, 刘晓光. 经脐缘两孔法腹腔镜阑尾切除术的临床疗效[J]. 腹腔镜外科杂志, 2022, 27(11): 854-857.
[24] Tyagi, S., Sinha, R. and Tyagi, A. (2017) Single Incision Laparoscopic Cholecystectomy: Less Scar, Less Pain. Journal of Minimal Access Surgery, 13, 118-123. [Google Scholar] [CrossRef] [PubMed]
[25] 韩福洲, 屈桓玮, 李文强, 等. 经脐单孔腹腔镜阑尾切除术在急性复杂性阑尾炎治疗中的有效性及安全性分析: 一项单中心、回顾性研究[J]. 临床外科杂志, 2023, 31(12): 1172-1175.
[26] Han, Y., Yuan, H., Li, S. and Wang, W. (2024) Single-Incision versus Conventional Three-Port Laparoscopic Appendectomy for Acute Appendicitis: A Meta-Analysis of Randomized Controlled Trials. Asian Journal of Surgery, 47, 864-873. [Google Scholar] [CrossRef] [PubMed]
[27] Cirocchi, R., Cianci, M.C., Amato, L., Properzi, L., Buononato, M., Di Rienzo, V.M., et al. (2024) Laparoscopic Appendectomy with Single Port vs Conventional Access: Systematic Review and Meta-Analysis of Randomized Clinical Trials. Surgical Endoscopy, 38, 1667-1684. [Google Scholar] [CrossRef] [PubMed]
[28] Cai, Y., Lopata, L., Roh, A., Huang, M., Monteleone, M.A., Wang, S., et al. (2017) Factors Influencing Postoperative Pain Following Discharge in Pediatric Ambulatory Surgery Patients. Journal of Clinical Anesthesia, 39, 100-104. [Google Scholar] [CrossRef] [PubMed]
[29] 王子恺, 李闻. 经自然腔道内镜外科学(NOTES)研究进展[J]. 胃肠病学和肝病学杂志, 2012, 21(4): 298-303.
[30] Slouha, E., Biput, S.J., Krumbach, B., Clunes, L.A. and Kollias, T.F. (2024) Transvaginal Laparoscopic Appendectomy: A Systematic Review. Cureus, 16, e51962. [Google Scholar] [CrossRef] [PubMed]
[31] Khan, A.Q., Liu, E., Niu, W., Li, P., Gul, H., Fokeerchand, J., et al. (2016) Transvaginal Laparoscopically-Assisted Endoscopic Appendectomy: A Major Hybrid Natural Orifice Transluminal Endoscopic Surgery Case Series in Asia. International Surgery, 101, 153-160. [Google Scholar] [CrossRef] [PubMed]
[32] 张继新, 胡军红, 谢爽, 等. 经阴道单孔腹腔镜阑尾切除术可行性及近期疗效分析[J]. 中华结直肠疾病电子杂志, 2023, 12(6): 460-465.
[33] 黄鹏宇, 郭先文. NOTES相关并发症的研究进展[J]. 微创医学, 2014, 9(3): 327-330.
[34] 刘丹. 经自然腔道内镜阑尾切除术的发展现状与前景[C]//《中国微创外科杂志》编辑部. 2011年全国微创外科高峰论坛暨《中国微创外科杂志》创刊十周年庆典论文集. 2011: 149-151.
[35] 韩小宏, 蒋建庭, 李立波, 等. 肥胖女性患者腹腔镜阑尾切除术53例报告[J]. 中国微创外科杂志, 2010, 10(1): 84-85.
[36] 郑永波, 阎春雷, 马翔, 等. 腹腔镜阑尾切除术的临床优势[J]. 白求恩军医学院学报, 2012, 10(1): 46-47.
[37] 张庆鹏, 卫勃, 陈凛. 腹腔镜在65岁以上胃肠外科急腹症患者手术中的应用[J]. 中华胃肠外科杂志, 2015(8): 797-800.
[38] Markides, G., Subar, D. and Riyad, K. (2010) Laparoscopic versus Open Appendectomy in Adults with Complicated Appendicitis: Systematic Review and Meta-Analysis. World Journal of Surgery, 34, 2026-2040. [Google Scholar] [CrossRef] [PubMed]
[39] Yilmaz, S., Donmez, T., Ferahman, S., Akarsu, C., Bulut, S., Ozcevik, H., et al. (2021) Partial Cecum Resection Using Endostapler in Acute Complicated Appendicitis with Appendiceal Base Necrosis. Videosurgery and Other Miniinvasive Techniques, 17, 143-149. [Google Scholar] [CrossRef] [PubMed]
[40] 张永旺, 侯花屏, 李文斌, 等. 早期手术与传统非手术治疗阑尾周围脓肿的临床效果比较[J]. 临床医学研究与实践, 2025, 10(7): 82-85.
[41] 焦宇文, 傅跃, 高官壮, 等. 不同方式治疗阑尾周围脓肿的临床效果观察[J]. 手术电子杂志, 2022, 9(6): 21-25.
[42] 叶中伟. I期手术切除治疗阑尾周围脓肿的效果研究[J]. 中国实用医药, 2019, 14(16): 56-57.
[43] Rifai, A.O., Rembetski, E.M., Stutts, L.C., Mazurek, Z.D., Yeh, J.L., Rifai, K., et al. (2023) Retrospective Analysis of Operative Time and Time to Discharge for Laparoscopic vs Robotic Approaches to Appendectomy and Cholecystectomy. Journal of Robotic Surgery, 17, 2187-2193. [Google Scholar] [CrossRef] [PubMed]
[44] You, K.S., Kim, D.H., Yun, H.Y., et al. (2012) The Value of a Laparoscopic Interval Appendectomy for Treatment of a Periappendiceal Abscess: Experience of a Single Medical Center. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 22, 127-130. [Google Scholar] [CrossRef] [PubMed]
[45] Mohammed, O.H., Humidan, A.A.M., Ahmed, A.S., Ahmed, S.S., Ibrahim, R.F., Omer, M.A.E., et al. (2024) Efficacy of Antibiotic Therapy Alone versus Antibiotics with Percutaneous Drainage in Periappendiceal Abscess: A Systematic Review and Meta-Analysis. Cureus, 16, e73979. [Google Scholar] [CrossRef] [PubMed]
[46] Chang, C.R. and Cheng, C.Y. (2014) Drainage of Periappendiceal Abscess and Removal of Free Fecalith—Extraperitoneal Approach. International Surgery, 99, 379-383. [Google Scholar] [CrossRef] [PubMed]
[47] 王鑫慧, 冯伟, 王月, 等. 保守治疗与早期阑尾切除术对阑尾周围脓肿疗效比较的Meta分析[J]. 天津医科大学学报, 2020, 26(6): 563-568.
[48] 董翼, 谈善军, 方勇, 等. 腹腔镜手术与保守方法治疗阑尾周围脓肿的Meta分析[J]. 中华胃肠外科杂志, 2018, 21(12): 1433-1438.
[49] 季添翼, 邱思桐, 曹国锋, 等. 单孔腹腔镜与传统腹腔镜在治疗儿童急性阑尾炎中的疗效对比研究[J]. 南通大学学报(医学版), 2024, 44(2): 150-153.
[50] Pogorelic, Z., Buljubasic, M., Susnjar, T., Jukic, M., Pericic, T.P. and Juric, I. (2019) Comparison of Open and Laparoscopic Appendectomy in Children: A 5-Year Single Center Experience. Indian Pediatrics, 56, 299-303. [Google Scholar] [CrossRef
[51] McMullin, J.L., Hu, Q.L., Merkow, R.P., Bilimoria, K.Y., Hu, Y., Ko, C.Y., et al. (2022) Are Kids More than Just Little Adults? A Comparison of Surgical Outcomes. Journal of Surgical Research, 279, 586-591. [Google Scholar] [CrossRef] [PubMed]
[52] Hernandez, M.C., Finnesgard, E.J., Aho, J.M., Jenkins, D.H. and Zielinski, M.D. (2018) Association of Postoperative Organ Space Infection after Intraoperative Irrigation in Appendicitis. Journal of Trauma and Acute Care Surgery, 84, 628-635. [Google Scholar] [CrossRef] [PubMed]
[53] Johnson, K.N., Linnaus, M. and Notrica, D.M. (2018) Conversion from Laparoscopic to Open Appendectomy: Decreased Risk at Dedicated Children’s Hospitals. Pediatric Surgery International, 34, 873-877. [Google Scholar] [CrossRef] [PubMed]
[54] Rolle, U., Bechstein, W.O., Fahlenbrach, C., Heller, G., Meyer, H., Schuler, E., et al. (2024) The Outcome of Laparoscopic versus Open Appendectomy in Childhood. Deutsches Ärzteblatt International, 21, 39-44. [Google Scholar] [CrossRef] [PubMed]
[55] 冯健, 崔乃强. 老年急性阑尾炎患者单孔腹腔镜和腹腔镜与开腹阑尾切除术的对比研究[J]. 中华老年医学杂志, 2019, 38(11): 1266-1269.
[56] 杨志勇, 吴永哲, 安宏超, 等. 腹腔镜阑尾切除术治疗老年急性阑尾炎的疗效[J]. 中国老年学杂志, 2017, 37(9): 2249-2250.
[57] Wang, D., Dong, T., Shao, Y., Gu, T., Xu, Y. and Jiang, Y. (2019) Laparoscopy versus Open Appendectomy for Elderly Patients, a Meta-Analysis and Systematic Review. BMC Surgery, 19, Article No. 54. [Google Scholar] [CrossRef] [PubMed]
[58] Kot, A., Kenig, J. and Wałęga, P. (2016) Treatment of Acute Appendicitis in Geriatric Patients—Literature Review. Polish Journal of Surgery, 88, 136-141. [Google Scholar] [CrossRef] [PubMed]
[59] Moon, K.S., Jung, Y.H., Lee, E.H. and Hwang, Y.H. (2012) Clinical Characteristics and Surgical Safety in Patients with Acute Appendicitis Aged over 80. Journal of the Korean Society of Coloproctology, 28, 94-99. [Google Scholar] [CrossRef] [PubMed]
[60] Prodromidou, A., Machairas, N., Kostakis, I.D., Molmenti, E., Spartalis, E., Kakkos, A., et al. (2018) Outcomes after Open and Laparoscopic Appendectomy during Pregnancy: A Meta-Analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 225, 40-50. [Google Scholar] [CrossRef] [PubMed]
[61] Cheng, V., Ashbrook, M., Youssefzadeh, A.C., et al. (2023) Management for Acute Uncomplicated Appendicitis during Pregnancy: National Trends and Patient Outcomes. Annals of Surgery, 278, 932-936. [Google Scholar] [CrossRef] [PubMed]
[62] Lipping, E., Saar, S., Rull, K., Tark, A., Tiiman, M., Jaanimäe, L., et al. (2023) Open versus Laparoscopic Appendectomy for Acute Appendicitis in Pregnancy: A Population-Based Study. Surgical Endoscopy, 37, 6025-6031. [Google Scholar] [CrossRef] [PubMed]
[63] Seok, J.W., Son, J., Jung, K.U., Lee, S.R. and Kim, H.O. (2021) Safety of Appendectomy during Pregnancy in the Totally Laparoscopic Age. Journal of Minimally Invasive Surgery, 24, 68-75. [Google Scholar] [CrossRef] [PubMed]
[64] Guňková, P., Tulinský, L., Toman, D., Martínek, L., Vrtková, A., Špaček, R., et al. (2024) Acute Appendicitis in Pregnancy—Do We Treat Correctly, or Do We Delay Unnecessarily? Ginekologia Polska, 95, 126-131. [Google Scholar] [CrossRef] [PubMed]
[65] Şengel, A., Büyükfırat, E., Seçilmiş, S., Altay, N., Atlas, A. and Karahan, M.A. (2025) Comparison of Bilateral versus Unilateral Transversus Abdominis Plane Block Combined with Spinal Anesthesia in Laparoscopic Appendectomy: A Retrospective Observational Study. Diagnostics, 15, Article 2122. [Google Scholar] [CrossRef
[66] 杨健发, 王俊晖, 邓媛, 等. 腹横肌平面阻滞联合舒芬太尼对腹腔镜阑尾切除术患者术后镇痛的影响[J]. 中国医学创新, 2024, 21(17): 37-40.
[67] 韩彬, 王武涛, 何爱萍. 超声引导下腰方肌阻滞或腹横肌平面阻滞联合舒芬太尼PCIA在阑尾切除术后镇痛中的比较[J]. 临床麻醉学杂志, 2017, 33(10): 984-986.
[68] Sandeman, D.J., Bennett, M., Dilley, A.V., Perczuk, A., Lim, S. and Kelly, K.J. (2011) Ultrasound-Guided Transversus Abdominis Plane Blocks for Laparoscopic Appendicectomy in Children: A Prospective Randomized Trial. British Journal of Anaesthesia, 106, 882-886. [Google Scholar] [CrossRef] [PubMed]
[69] 中华医学会外科学分会, 中华医学会麻醉学分会. 中国加速康复外科临床实践指南(2021版) [J]. 中国实用外科杂志, 2021, 41(9): 961-992.
[70] 高晋鸿, 郝少龙, 刘勇, 等. 加速康复外科理念下围手术期疼痛管理在日间腹腔镜阑尾切除术中的应用[J]. 中华普通外科学文献(电子版), 2022, 16(2): 146-150.
[71] Dai, L. and Shuai, J. (2017) Laparoscopic versus Open Appendectomy in Adults and Children: A Meta‐Analysis of Randomized Controlled Trials. United European Gastroenterology Journal, 5, 542-553. [Google Scholar] [CrossRef] [PubMed]
[72] Wei, H.B., Huang, J.L., Zheng, Z.H., et al. (2009) Laparoscopic versus Open Appendectomy: A Prospective Randomized Comparison. Surgical Endoscopy, 24, 266-269. [Google Scholar] [CrossRef] [PubMed]
[73] Waghmare, P. and Shih, I. (2024) RWD25 Trends and Utilization of Open, Laparoscopic, and Robotic-Assisted Appendectomy: A Retrospective Database Study. Value in Health, 27, S361. [Google Scholar] [CrossRef