膝骨关节炎与肠道微生物的相关性研究进展
Research Progress on Relationship between Knee Osteoarthritis and Intestinal Flora
DOI: 10.12677/acm.2025.15103007, PDF,    科研立项经费支持
作者: 白曙明, 白福贵, 那阿乐木斯, 苏力德, 巴虎山*：内蒙古自治区国际蒙医医院蒙医骨伤科，内蒙古 呼和浩特
关键词: 膝骨关节炎；肠道微生物；代谢紊乱；免疫；Knee Osteoarthritis (KOA)； Intestinal Flora； Metabolic Disorders； Immune
摘要: 膝骨关节炎(knee osteoarthritis, KOA)是一种多因素多病理改变的全关节疾病，在中老年人群中患病率高、致残率高，给社会造成巨大经济负担，但目前KOA病理机制尚未阐明。随着年龄的增加，人体肠道菌群也逐渐发生改变。肠道微生物是一个复杂的微生态系统，研究表明肠道菌群在许多疾病包括骨关节炎在内的发病机制中扮演重要角色。本文基于“肠–关节”轴视角，综述了现代微生态学的观点对肠道微生物与KOA的相关性，还特别展望了传统蒙医药通过调节肠道微生态以防治KOA的潜在价值与未来研究方向，以期为今后该领域提供新的治疗思路。
Abstract: Knee osteoarthritis (KOA) is a total joint disease with multiple factors and pathological changes, which has a high prevalence and disability rate in middle-aged and elderly people, causing a huge economic burden to society. However, the pathological mechanism of KOA has not been clarified yet. With the increase of age, the human intestinal flora also gradually changes. Gut microbiota is a complex microecosystem, and studies have shown that gut microbiota plays an important role in the pathogenesis of many diseases, including osteoarthritis. Based on the perspective of the “Gut-Joint” Axis, this review expounded the correlation between intestinal microbiota and KOA from the viewpoints of modern microecology. It also particularly looks forward to the potential value and future research directions of traditional Mongolian medicine in preventing and treating KOA by regulating intestinal microecology, with the aim of providing new therapeutic ideas for this field in the future.
文章引用：白曙明, 白福贵, 那阿乐木斯, 苏力德, 巴虎山. 膝骨关节炎与肠道微生物的相关性研究进展[J]. 临床医学进展, 2025, 15(10): 2247-2251. https://doi.org/10.12677/acm.2025.15103007

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