阿芬太尼用于无痛胃肠镜检查的研究进展

Research Progress of Alfentanil in Painless Gastrointestinal Endoscopy Examination

摘要: 胃肠镜检查是消化系统疾病诊疗的金标准，具有直观、准确等优点，但其属于侵入操作，操作过程中由于刺激患者咽喉部，可引起呛咳、恶心、呕吐、心率加快、躁动、血压升高等一系列不良反应。随着胃镜技术的不断发展和人们对诊疗需求、舒适需求的提高，无痛胃肠镜成为患者检查的首选，目前已广泛应用于消化系统疾病的临床诊疗中。阿芬太尼作为新型的超短效μ受体镇痛药，具有起效快，作用持续时间短，对呼吸的抑制小等优点，目前小剂量的阿芬太尼复合丙泊酚已在临床广泛应用。本文就近年来行无痛胃肠镜检查的麻醉药物选择作一简要综述，以期为无痛胃镜检查的合理化用药提供一定的依据。

Abstract: Gastrointestinal endoscopy is the gold standard for the diagnosis and treatment of digestive system diseases, with advantages such as direct visualization and accuracy. However, it is an invasive procedure, and during the operation, stimulation of the patient’s pharynx can cause a series of adverse reactions such as coughing, nausea, vomiting, increased heart rate, restlessness, and elevated blood pressure. With the continuous development of gastroscopy technology and the increasing demands for diagnosis and treatment as well as comfort, painless gastrointestinal endoscopy has become the preferred choice for patients and is now widely used in the clinical diagnosis and treatment of digestive system diseases. Alfentanil, as a new ultra-short-acting μ-receptor analgesic, has the advantages of rapid onset, short duration of action, and minimal respiratory depression. Currently, low-dose alfentanil combined with propofol is widely used in clinical practice. This article provides a brief review of the selection of anesthetic drugs for painless gastrointestinal endoscopy in recent years, with the aim of providing a certain basis for rational drug use in painless gastroscopy.