儿脾醒颗粒治疗小儿功能性消化不良综合征临床疗效观察

Clinical Efficacy Observation of Erpixing Granules in Treating Functional Dyspepsia Syndrome in Children

摘要: 目的：探讨儿脾醒颗粒治疗小儿功能性消化不良综合征临床疗效及安全性。方法：选取我院2022年2月~2025年2月收治的90例功能性消化不良的患儿作为研究对象。采用随机数字法进行分组，分为对照组：45例；观察组：45例。对照组给予西药治疗，观察组联合儿脾醒颗粒治疗。比较两组患者的临床疗效、中医证候评分、胃肠功能指标(胃泌素、胃动素)及不良反应。结果：对照组总有效率为82.22%，观察组总有效率为95.56%，两组患者临床疗效相比，具有统计学意义(χ² = 11.465, P = 0.024)。治疗后与对照组相比，观察组在嗳气、早饱、恶心、腹部胀痛、食欲减退中医证候积分均明显降低，具有统计学意义(P < 0.05)。观察组在治疗后MTL、GAS水平均明显高于对照组，具有统计学意义(P < 0.05)。两组患者不良反应发生率相比，无统计学意义(P > 0.05)。结论：儿脾醒颗粒联合枯草杆菌二联活菌颗粒治疗小儿功能性消化不良，临床疗效确切，能改善患者临床症状及胃肠功能，提高患者生活质量，且临床用药安全性较好。

Abstract: Objective: To explore the clinical effect of Erpixing Granules in treating pediatric functional dyspepsia syndrome. Methods: 90 patients with functional dyspepsia were admitted to our hospital from February 2022~February 2025. It was divided into control group (45 cases); observation group (45 cases). The control group was given western medicine treatment, and the observation group was treated with Erpixing Granules. Comparing the clinical efficacy, Traditional Chinese Medicine (TCM) syndrome scores, gastrointestinal function indicators (gastrin, motilin), and adverse reactions between two groups of patients. Results: The total response rate of the control group was 82.22%, and the observation group was 95.56%, with statistically significant (χ² = 11.465, P = 0.024). After treatment, compared with the control group, the observation group showed significantly lower TCM syndrome scores in belching, early satiety, nausea, abdominal distension and pain, and decreased appetite, with statistical significance (P < 0.05). The observation group had significantly higher levels of MTL and GAS than the control group after treatment (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The combination of Erpixing granules and Live combined bacillus subtilis and enterococcus faecium granules in treating pediatric functional dyspepsia demonstrates definite clinical efficacy, improves patients’ clinical symptoms and gastrointestinal function, enhances their quality of life, and exhibits good clinical medication safety.