中药单体治疗多囊卵巢综合征高尿酸血症的研究进展
Research Progress on the Treatment of Hyperuricemia in Polycystic Ovary Syndrome with Monomers of Traditional Chinese Medicine
DOI: 10.12677/acm.2025.15113065, PDF,   
作者: 罗 娜:黑龙江中医药大学研究生院,黑龙江 哈尔滨;李 妍*:黑龙江中医药大学附属第一医院中医转化医学研究中心,黑龙江 哈尔滨
关键词: 多囊卵巢综合征高尿酸血症中药单体Polycystic Ovary Syndrome Hyperuricemia Traditional Chinese Medicine Monomer
摘要: 多囊卵巢综合征(PCOS)是育龄期女性常见的内分泌疾病,以排卵障碍、高雄激素血症、卵巢多囊样改变为主要特征。高尿酸血症(HUA)是指体内嘌呤代谢紊乱导致血液中尿酸水平升高的慢性代谢性疾病。近年越来越多研究表明,二者关系密切,相互影响。然而,PCOS-HUA的发病机制目前尚不明确,临床上也尚未形成系统的治疗方案,但部分中药单体在PCOS-HUA的治疗中展现出良好的效果,本文对相关内容进行归纳总结,期望对PCOS-HUA的临床诊疗及新药研发提供参考依据。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of childbearing age, characterized by ovulation disorders, hyperandrogenemia and ovarian polycystic changes. Hyperuricemia (HUA) refers to a chronic metabolic disease in which purine metabolism disorders in the body cause elevated uric acid levels in the blood. In recent years, more and more studies have shown that the two are closely related and interact with each other. However, the pathogenesis of PCOS-HUA is not clear at present, and a systematic treatment plan has not yet been formed clinically. However, some traditional Chinese medicine monomers have shown good results in the treatment of PCOS-HUA. This article summarizes the relevant content, hoping to provide a reference basis for the clinical diagnosis and treatment of PCOS-HUA and the research and development of new drugs.
文章引用:罗娜, 李妍. 中药单体治疗多囊卵巢综合征高尿酸血症的研究进展[J]. 临床医学进展, 2025, 15(11): 56-60. https://doi.org/10.12677/acm.2025.15113065

参考文献

[1] Escobar-Morreale, H.F. (2018) Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment. Nature Reviews Endocrinology, 14, 270-284. [Google Scholar] [CrossRef] [PubMed]
[2] Lee, J.W., Kwon, B.C. and Choi, H.G. (2021) Analyses of the Relationship between Hyperuricemia and Osteoporosis. Scientific Reports, 11, Article No. 12080. [Google Scholar] [CrossRef] [PubMed]
[3] 中国民族卫生协会重症代谢疾病分会, 高尿酸血症相关疾病诊疗多学科共识专家组. 中国高尿酸血症相关疾病诊疗多学科专家共识(2023年版) [J]. 中国实用内科杂志, 2023, 43(6): 461-480.
[4] El-Eshmawy, M.M., Ibrahim, A., Bahriz, R., Shams-Eldin, N. and Mahsoub, N. (2022) Serum Uric Acid/Creatinine Ratio and Free Androgen Index Are Synergistically Associated with Increased Risk of Polycystic Ovary Syndrome in Obese Women. BMC Endocrine Disorders, 22, Article No. 315. [Google Scholar] [CrossRef] [PubMed]
[5] Androulakis, I.I., Kandaraki, E., Christakou, C., Karachalios, A., Marinakis, E., Paterakis, T., et al. (2014) Visceral Adiposity Index (VAI) Is Related to the Severity of Anovulation and Other Clinical Features in Women with Polycystic Ovary Syndrome. Clinical Endocrinology, 81, 426-431. [Google Scholar] [CrossRef] [PubMed]
[6] 王梅, 王维静, 王芳. 复发性流产患者血清尿酸与胰岛素抵抗的关联分析[J]. 实用妇产科杂志, 2024, 40(9): 739-744.
[7] 夏依达·乌斯满江, 夏木斯叶·木依都力, 阿迪拉·苏力旦, 等. 高尿酸血症与中心性肥胖关系的研究进展[J]. 中国校医, 2024, 38(8): 627-630.
[8] 杨清, 李慕白. 黄连素治疗多囊卵巢综合征的作用机制[J]. 中文科技期刊数据库(全文版)医药卫生, 2021(11): 334-335.
[9] 郑慧颖, 叶南芳. 黄连素对多囊卵巢综合征大鼠高雄激素状态及性激素结合球蛋白的影响[J]. 中国医药指南, 2025, 23(10): 6-9.
[10] 杨宇琦, 吴丽娜, 孙克, 等. 黄连素通过重塑肠道菌群和调节PI3K/AKT信号通路改善多囊卵巢综合征小鼠的作用机制研究[J]. 疑难病杂志, 2024, 23(3): 352-359.
[11] 秦泽慧. 黄连素与牛磺胆酸钠自组装纳米粒的构建、释放及抗高尿酸血症药效评价[D]: [硕士学位论文]. 广州: 广州中医药大学, 2024.
[12] 徐碧林, 盛鲁光, 刘丹丹, 等. 虎杖及虎杖苷对肥胖小鼠脂肪组织脂质沉积的影响[J]. 中成药, 2025, 47(9): 2912-2917.
[13] 崔亚斌, 贾云涛, 邬朋格, 等. 虎杖苷联合甘草汁对大鼠血清性激素作用及与多囊卵巢综合征的研究[J]. 智慧健康, 2020, 6(34): 171-173+186.
[14] 高雪林. 虎杖苷对多囊卵巢综合征的治疗作用及其机制研究[D]: [硕士学位论文]. 兰州: 兰州大学, 2018.
[15] Li, N., Amatjan, M., He, P., Zhang, B., Mai, X., Jiang, Q., et al. (2022) Integration of Network Pharmacology and Intestinal Flora to Investigate the Mechanism of Action of Chinese Herbal Cichorium intybus Formula in Attenuating Adenine and Ethambutol Hydrochloride-Induced Hyperuricemic Nephropathy in Rats. Pharmaceutical Biology, 60, 2338-2354. [Google Scholar] [CrossRef] [PubMed]
[16] Jahan, S., Abid, A., Khalid, S., Afsar, T., Qurat-Ul-Ain, Shaheen, G., et al. (2018) Therapeutic Potentials of Quercetin in Management of Polycystic Ovarian Syndrome Using Letrozole Induced Rat Model: A Histological and a Biochemical Study. Journal of Ovarian Research, 11, Article No. 26. [Google Scholar] [CrossRef] [PubMed]
[17] 江雪娟, 陈晓菲, 俞佳, 等. 槲皮素对多囊卵巢综合征大鼠的改善作用[J]. 中成药, 2023, 45(7): 2179-2184.
[18] Neisy, A., Zal, F., Seghatoleslam, A. and Alaee, S. (2018) Amelioration by Quercetin of Insulin Resistance and Uterine GLUT4 and ERα Gene Expression in Rats with Polycystic Ovary Syndrome (PCOS). Reproduction, Fertility and Development, 31, 315-323. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, C., Wang, R., Zhang, G. and Gong, D. (2018) Mechanistic Insights into the Inhibition of Quercetin on Xanthine Oxidase. International Journal of Biological Macromolecules, 112, 405-412. [Google Scholar] [CrossRef] [PubMed]
[20] Hu, Q., Zhang, X., Wang, X., Jiao, R. and Kong, L. (2011) Quercetin Regulates Organic Ion Transporter and Uromodulin Expression and Improves Renal Function in Hyperuricemic Mice. European Journal of Nutrition, 51, 593-606. [Google Scholar] [CrossRef] [PubMed]
[21] 梁子俊, 梁广. 人参属植物珠子参的研究进展[J]. 中国现代应用药学, 2025, 42(16): 2911-2924.
[22] Choi, J.H., Jang, M., Kim, E., Lee, M.J., Park, K.S., Kim, S., et al. (2020) Korean Red Ginseng Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats via Its Antiinflammatory and Antioxidant Activities. Journal of Ginseng Research, 44, 790-798. [Google Scholar] [CrossRef] [PubMed]
[23] 朱子成, 潘具洁, 陈蓓蓓, 等. 植物雌激素防治高尿酸血症及其并发症的研究进展[J]. 现代药物与临床, 2025, 40(4): 1059-1064.
[24] 马晓艳, 戴江东, 胡书绮, 等. 丹参酮组分“液态自微乳-固态分散微片”复合载药系统的构建与应用[J/OL]. 中国中药杂志: 1-14. 2025-09-27.[CrossRef
[25] Jin, J., Hu, Q., Xu, W., Zhu, W., Liu, B., Liu, J., et al. (2019) Tanshinone IIA Attenuates Estradiol-Induced Polycystic Ovarian Syndrome in Mice by Ameliorating FSHR Expression in the Ovary. Experimental and Therapeutic Medicine, 17, 3501-3508. [Google Scholar] [CrossRef] [PubMed]
[26] Wei, Y., Gao, J., Qin, L., Xu, Y., Wang, D., Shi, H., et al. (2017) Tanshinone I Alleviates Insulin Resistance in Type 2 Diabetes Mellitus Rats through IRS-1 Pathway. Biomedicine & Pharmacotherapy, 93, 352-358. [Google Scholar] [CrossRef] [PubMed]
[27] 靳宜静, 李堪董, 詹智晖, 等. 丹参酮ⅡA对小鼠高尿酸血症及并发心肌损伤的影响[J]. 中国组织化学与细胞化学杂志, 2024, 33(3): 232-238.