针药结合治疗肥胖型多囊卵巢综合征的研究进展
Progress on the Combination of Acupuncture and Medicine in the Treatment of Obese Polycystic Ovary Syndrome
DOI: 10.12677/acm.2025.15113126, PDF,    国家自然科学基金支持
作者: 王书芳:黑龙江中医药大学研究生院,黑龙江 哈尔滨;张跃辉*:黑龙江中医药大学附属第一医院妇科一科,黑龙江 哈尔滨
关键词: 针药结合多囊卵巢综合征肥胖胰岛素抵抗Combination of Acupuncture and Medicine Polycystic Ovary Syndrome Obesity Insulin Resistance
摘要: 多囊卵巢综合征(Polycystic Ovary Syndrome, PCOS)是育龄期女性常见的内分泌疾病,临床发病率较高,影响着6%~20%的育龄期妇女。PCOS患者大多伴有肥胖,肥胖型PCOS患者发生代谢综合征的几率高于非肥胖患者,且超过50%的PCOS患者存在胰岛素抵抗。本病常见的治疗有改善生活方式、口服药物,但存在依从性低、卵巢过度刺激征和禁忌症等。研究表明针灸作为中医辅助疗法,联合药物治疗本病具有疗效显著、副作用小、医疗成本低且安全性高的优点,故将其研究进展论述如下。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of childbearing age, with a relatively high clinical incidence rate, affecting 6% to 20% of women in this age group. Most PCOS patients are accompanied by obesity. The probability of metabolic syndrome in obese PCOS patients is higher than that in non-obese patients, and more than 50% of PCOS patients have insulin resistance. Common treatments for this disease include lifestyle improvement and oral medication, but they have disadvantages such as low compliance, ovarian hyperstimulation syndrome, and contraindications. Studies have shown that acupuncture, as an auxiliary therapy in traditional Chinese medicine, combined with drug treatment for this disease has the advantages of significant efficacy, few side effects, low medical costs, and high safety. Therefore, the research progress of this method is discussed as follows.
文章引用:王书芳, 张跃辉. 针药结合治疗肥胖型多囊卵巢综合征的研究进展[J]. 临床医学进展, 2025, 15(11): 522-527. https://doi.org/10.12677/acm.2025.15113126

参考文献

[1] Zhao, H., Zhang, J., Cheng, X., Nie, X. and He, B. (2023) Insulin Resistance in Polycystic Ovary Syndrome across Various Tissues: An Updated Review of Pathogenesis, Evaluation, and Treatment. Journal of Ovarian Research, 16, Article No. 9. [Google Scholar] [CrossRef] [PubMed]
[2] 周惠芳, 洪艳丽, 刁飞扬, 等. 多囊卵巢综合征中西医结合诊疗指南(2024年版) [J]. 中医杂志, 2025, 66(6): 649-656.
[3] Kim, C. and Lee, S. (2022) Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-analysis. Life, 12, Article 308. [Google Scholar] [CrossRef] [PubMed]
[4] 蔺文娟, 李鹤, 芮守月, 等. 基于IL-6/PI3K/AKT信号通路探讨补肾助排汤对多囊卵巢综合征伴胰岛素抵抗的干预机制[J/OL]. 中国中医药信息杂志: 1-7. 2025-03-15.[CrossRef
[5] 王阳, 林青, 杜贞苹, 等. 多囊卵巢综合征(肾虚痰湿型)患者胰岛素抵抗的临床特征及危险因素分析[J]. 时珍国医国药, 2024, 35(9): 2174-2176.
[6] Stańczak, N.A., Grywalska, E. and Dudzińska, E. (2024) The Latest Reports and Treatment Methods on Polycystic Ovary Syndrome. Annals of Medicine, 56, Article ID: 2357737. [Google Scholar] [CrossRef] [PubMed]
[7] Sadeghi, H.M., Adeli, I., Calina, D., Docea, A.O., Mousavi, T., Daniali, M., et al. (2022) Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. International Journal of Molecular Sciences, 23, Article 583. [Google Scholar] [CrossRef] [PubMed]
[8] Hoeger, K.M., Dokras, A. and Piltonen, T. (2020) Update on PCOS: Consequences, Challenges, and Guiding Treatment. The Journal of Clinical Endocrinology & Metabolism, 106, e1071-e1083. [Google Scholar] [CrossRef] [PubMed]
[9] 伍洲梁, 柴诚诚, 孟令萃, 等. 俞募配穴针灸治疗多囊卵巢综合征的临床研究[J]. 时珍国医国药, 2024, 35(7): 1685-1687.
[10] 贾凡, 刘新敏, 陈如枫, 等. 中医药治疗多囊卵巢综合征胰岛素抵抗的研究进展[J]. 时珍国医国药, 2022, 33(8): 1971-1974.
[11] 石学敏, 刘保延. 针药结合学[M]. 北京: 中国中医药出版社: 2021: 504.
[12] 余文彩, 王春霞, 李鹏超, 等. 中医诊疗多囊卵巢综合征的思路与方法[J]. 辽宁中医杂志, 2024, 51(12): 197-199.
[13] 施茵, 廖晏君, 虞莉青, 等. 针药结合治疗肥胖型多囊卵巢综合征患者33例临床观察[J]. 中医杂志, 2012, 53(22): 1930-1933.
[14] 颜艳芳, 陈理伟, 俞景晖, 等. 中药结合针灸疗法治疗肾虚痰瘀型多囊卵巢综合征30例临床观察[J]. 浙江中医杂志, 2022, 57(9): 666-667.
[15] 任秋伟, 孙杰, 崔绍彬, 等. 自拟五子泄浊汤联合针刺治疗肥胖型多囊卵巢综合征糖脂代谢及排卵率的影响[J]. 中华中医药学刊, 2025, 43(2): 229-232.
[16] 李香玉, 李久现, 孙烁, 等. 穴位埋线联合补肾利湿活血汤治疗PCOS合并IR [J]. 中医学报, 2025, 40(4): 876-883.
[17] 周全, 施斌, 黄梅花, 等. 苍附导痰丸联合腹针对肥胖型多囊卵巢综合征患者的临床疗效[J]. 中成药, 2024, 46(9): 2950-2953.
[18] 李永红, 刘玉洁, 赵燕燕, 等. 苍附导痰汤联合通元针法对脾虚痰湿型多囊卵巢综合征患者脂代谢、性激素和子宫内膜容受性的影响[J]. 现代生物医学进展, 2023, 23(3): 519-523.
[19] 毛雪文, 沈凌宇, 曾沁, 等. 针药联合治疗腹部肥胖型多囊卵巢综合征临床疗效研究[J]. 北京中医药, 2021, 40(12): 1321-1324.
[20] 罗佩, 侯丽莹, 邓丽玲, 等. 丹栀逍遥散联合针刺治疗多囊卵巢综合征30例临床观察[J]. 湖南中医杂志, 2017, 33(6): 19-20, 25.
[21] 赵振钏, 梁莹, 高星, 等. 针刺联合定坤丹治疗肝郁气滞型多囊卵巢综合征疗效[J]. 中华中医药学刊, 2020, 38(5): 194-198.
[22] 马桂芝, 胡智海, 施茵, 等. 穴位埋线联合二甲双胍对肥胖型多囊卵巢综合征患者糖脂代谢的影响[J]. 上海针灸杂志, 2020, 39(9): 1123-1127.
[23] 何丹娟, 梁少荣, 葛曼, 等. 穴位埋线联合二甲双胍对肥胖型多囊卵巢综合征患者糖脂代谢的影响[J]. 上海针灸杂志, 2020, 39(12): 1516-1520.
[24] 吴丹, 王晓滨, 丛慧芳, 等. 针灸对肥胖型多囊卵巢综合征患者卵巢功能的影响[J]. 世界中医药, 2020, 15(16): 2482-2485.
[25] 毕富玺, 吴林玲, 张晗, 等. 苍附导痰汤结合腹针治疗痰湿型多囊卵巢综合征的疗效观察[J]. 辽宁中医杂志, 2023, 50(11): 88-91.
[26] 邓晓丰, 徐琳. 针刺联合化痰助孕方对多囊卵巢综合征患者(痰湿困阻型)IL-6、HOMA-IR、HS-CRP、性激素及妊娠结局的影响[J]. 中国免疫学杂志, 2024, 40(1): 163-167.
[27] 滕婧, 杨柳. 祛湿化痰方联合针刺治疗脾虚痰湿型多囊卵巢综合征疗效研究[J]. 陕西中医, 2023, 44(12): 1813-1818.
[28] 李媛媛, 张佳, 常增伟, 等. 补肾化痰汤联合针刺治疗肥胖型多囊卵巢综合征的临床研究[J]. 转化医学杂志, 2024, 13(6): 953-957.
[29] 梁议方. 针药结合联合二甲双胍治疗肥胖型多囊卵巢综合征43例[J]. 环球中医药, 2018, 11(6): 958-960.