蒙西医治疗多发性骨髓瘤周围神经病变研究进展

Research Progress on the Treatment of Peripheral Neuropathy in Multiple Myeloma with Mongolian and Western Medicine

摘要: 多发性骨髓瘤(multiple myeloma, MM)属于血液系统恶性疾病，其特征为骨髓内浆细胞的异常克隆性增生。在血液系统肿瘤中，该病的发病率仅次于白血病，约占所有血液恶性肿瘤病例的10%。近年来随着化疗药物、新型靶向药物等被广泛应用于临床，MM治疗疗效有了显著的提高，但同时也增加了周围神经病变(peripheral neuropathy, PN)的发生率，不仅影响治疗效果，还对患者的生存质量造成严重损害。目前针对PN仍缺乏特异性治疗手段，临床主要采取预防和症状缓解策略，包括调整用药剂量、优化给药方案以及使用神经营养药物等支持性治疗。蒙医通过辨证施治和综合调理改善患者症状，提高生活质量。本文归纳、分析了蒙医对多发性骨髓瘤周围神经病变的认识，并对常用的蒙药方剂及五疗等作一综述，为今后满足患者需求提供有益的临床指导。

Abstract: Multiple myeloma (MM) is a malignant tumor characterized by clonal proliferation of plasma cells in the bone marrow. Among hematologic malignancies, this disease has the second-highest incidence rate after leukemia, accounting for approximately 10% of all hematologic malignancies. In recent years, with the extensive application of chemotherapy drugs and novel targeted drugs in clinical practice, the therapeutic efficacy of MM has significantly improved. However, this has also led to an increased incidence of peripheral neuropathy (PN), which seriously affects the therapeutic outcome and reduces the quality of life of patients. Currently, there are no effective treatment methods, and the focus is on prevention and symptomatic treatment. Western medicine mainly employs measures such as adjusting drug dosages, changing administration methods, and providing neurotrophic agents for symptomatic treatment. Mongolian medicine improves patient symptoms and enhances quality of life through syndrome differentiation and comprehensive conditioning. This article summarizes and analyzes the Mongolian medical understanding of peripheral neuropathy in multiple myeloma and provides a review of commonly used Mongolian medicinal formulas and five therapies, aiming to offer beneficial clinical guidance for meeting patient needs in the future.