煅石膏在创面修复领域中应用前景的探讨

Exploring the Application Prospects of Calcined Gypsum in the Field of Wound Repair

摘要: 煅石膏在古籍与现代药典记载中具有收湿敛疮、生肌止血的功效，常外用于溃疡，但临床作用于糖尿病足溃疡等创面修复的案例并不多，笔者从历史沿革与现代研究中，以文献挖掘的方式，对关于煅石膏与创面相关的现代研究进行整理和分析，为糖尿病溃疡等创面修复领域在临床治疗方案提供参考，以此进行阐述。煅石膏在促进创面愈合有良好的抗感染、抗菌和抗炎作用，特别是创面当中常见的大肠杆菌和金黄色葡萄球菌，通过抑制促炎细胞因子：肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、前列腺素E₂ (PGE₂)等炎性因子的表达起到抗炎的效果；其微量元素Ca²⁺参与机体凝血过程，还参与免疫系统吞噬细胞的应答。笔者通过对煅石膏在创面的相关研究进行总结，进一步了解到煅石膏的生物相容性和可塑性强，与中药和化学药物配伍使用能达到个体化治疗，如能作为新型敷料运用于创面修复，既可减轻患者经济负担，又可减轻清创换药带来的痛苦。

Abstract: Calcined gypsum, as recorded in ancient texts and modern pharmacopoeias, possesses the properties of absorbing dampness, healing sores, promoting tissue regeneration, and stopping bleeding. It is commonly used externally for ulcers; however, there are limited cases of its clinical application in the repair of chronic wounds such as diabetic foot ulcers. Through literature mining, the author has compiled and analyzed modern research related to calcined gypsum and infected wounds, drawing from historical evolution and contemporary studies, to provide references for clinical treatment strategies in the field of diabetic ulcer wound healing. Calcined gypsum demonstrates good anti-infective, antibacterial, and anti-inflammatory effects in promoting the healing of infected wounds, particularly against Escherichia coli and Staphylococcus aureus, which are commonly found in infected wounds. It exerts anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and prostaglandin E₂ (PGE₂). Additionally, its trace element Ca²⁺ is involved in the body’s coagulation process and the immune system’s phagocytic response. By summarizing the relevant research on calcined gypsum in infected wounds, the author has gained a deeper understanding of its strong biocompatibility and plasticity. When used in combination with traditional Chinese medicines and chemical drugs, it can achieve individualized treatment. If calcined gypsum can be applied as a novel dressing for chronic wounds such as diabetic foot ulcers, it can not only reduce the economic burden on patients but also alleviate the pain associated with wound debridement and dressing changes.