联合5-羟色胺相关药物治疗慢性痒疹临床疗效观察

Clinical Observation of Combined with 5-Hydroxytryptamine Related Drugs in the Treatment of Chronic Prurigo

摘要: 目的：探讨联合5-羟色胺相关药物(依匹斯汀胶囊、赛庚啶片)治疗慢性痒疹的临床疗效。方法：全部病例随机分成两组：A组(观察组)共40例：采用口服依匹斯汀胶囊、赛庚啶片，采用氟芬那酸丁酯(布特)软膏，卤米松乳膏，两者混合外涂；B组(对照组)共40例：采用氟芬那酸丁酯(布特)软膏，卤米松乳膏，两者混合外涂。结果：两组皮疹消退对比：A组总有效率为87.5%，B组总有效率为55.0%，两组总有效率经χ²检验，χ² = 10.31，P < 0.01，差异有统计学意义。两组瘙痒消退对比：A组总有效率为85.0%，B组总有效率为55.0%，两组总有效率经χ²检验，χ² = 8.57，P < 0.01，差异有统计学意义。说明A组疗效优于B组疗效。结论：5-羟色胺相关药物(依匹斯汀胶囊、赛庚啶片)治疗慢性痒疹取得较好疗效，值得临床推广。

Abstract: Objective: To investigate the clinical effect of 5-hydroxytryptamine-related drugs (Epinastine capsule, cyproheptadine tablets) in the treatment of chronic prurigo. Methods: All the patients were randomly divided into two groups: group A (observation group) 40 cases in total: using oral administration of Epinastine capsule, cyproheptadine tablets, using bufloxacin (Bute) ointment, Halometasone Cream, both mixed external application; group B (control group) 40 cases in total: using bufloxacin (Bute) ointment, Halometasone Cream, both mixed external applications. Results: Comparison of two groups in the disappearance of rash: the total effective rate was 87.5% in group A and 55.0% in group B. The total effective rate of the two groups was tested by χ² test, χ² =10.31, P < 0.01, the difference was statistically significant. Comparison of pruritus relief between the two groups: The total effective rate of group A and group B was 85.0% and 55.0%, respectively. The total effective rate of the two groups was tested by χ² test, χ² = 8.57, P < 0.01, the difference was statistically significant. It shows that the effect of group A is better than that of group B. Conclusion: 5-hydroxytryptamine-related drugs (Epinastine capsule, cyproheptadine tablets) have a good effect on chronic prurigo, and are worth clinical promotion.