糖尿病下肢血管病变的中西医治疗进展
Progress of Chinese and Western Medicine in the Treatment of Diabetic Lower Extremity Vascular Disease
DOI: 10.12677/jcpm.2025.46480, PDF,    科研立项经费支持
作者: 高 慧:黑龙江中医药大学研究生院,黑龙江 哈尔滨;王 景*:黑龙江中医药大学附属第二医院周围血管科,黑龙江 哈尔滨
关键词: 糖尿病下肢血管病变发病机制中西医治疗综述 Diabetic Lower Extremity Vascular Disease Pathogenesis Chinese and Western Medicine Treatment Review
摘要: 糖尿病下肢血管病变是常见的糖尿病并发症,严重危害患者健康,并带来沉重的经济负担。为梳理该病的最新治疗研究进展,本文综述了近年相关文献,重点探讨其中西医发病机制及常用治疗策略。结果表明,西医治疗在血管腔内技术等方面取得进展,但尚有再狭窄、感染等风险;中医通过辨证论治及外治法显示出良好疗效,但其起效的物质基础与作用机制尚未明确,制约了临床推广。中西医结合疗法在该病治疗中展现出独特优势,具有广阔的研究前景。
Abstract: Diabetic lower extremity vascular disease is a common complication of diabetes, posing a serious threat to patients’ health and imposing a significant economic burden. To summarize the latest research advances in the treatment of this condition, this review article summarizes recent relevant literature, focusing on the pathogenesis and common treatment strategies from both Western and traditional Chinese medicine perspectives. The results indicate that Western medicine has made progress in vascular endovascular techniques, but there are still risks such as restenosis and infection; traditional Chinese medicine has shown good efficacy through syndrome differentiation and treatment, as well as external therapies, but the material basis and mechanisms of action underlying its efficacy remain unclear, limiting its clinical application. Integrated traditional Chinese and Western medicine therapies demonstrate unique advantages in the treatment of this condition and hold promising research prospects.
文章引用:高慧, 王景. 糖尿病下肢血管病变的中西医治疗进展[J]. 临床个性化医学, 2025, 4(6): 77-84. https://doi.org/10.12677/jcpm.2025.46480

参考文献

[1] Zhang, X., Ran, X., Xu, Z., Cheng, Z., Shen, F., Yu, Y., et al. (2018) Epidemiological Characteristics of Lower Extremity Arterial Disease in Chinese Diabetes Patients at High Risk: A Prospective, Multicenter, Cross-Sectional Study. Journal of Diabetes and Its Complications, 32, 150-156. [Google Scholar] [CrossRef] [PubMed]
[2] Gao, Q., He, B., Zhu, C., Xiao, Y., Wei, L. and Jia, W. (2016) Factors Associated with Lower Extremity Atherosclerotic Disease in Chinese Patients with Type 2 Diabetes Mellitus. Medicine, 95, e5230. [Google Scholar] [CrossRef] [PubMed]
[3] 贾睿博, 徐琳. 2型糖尿病患者下肢血管病变相关危险因素调查研究[J]. 陕西医学杂志, 2019, 48(11): 1567-1570.
[4] 韩宇南, 李琳, 李玉洪, 等. 氧化应激在糖尿病并发症发病机制及治疗中的研究进展[J]. 中国临床研究, 2025, 38(4): 515-519.
[5] 杨晶, 赵衡, 刘江华. 内皮细胞在血管钙化进程中的作用[J]. 临床与病理杂志, 2020, 40(1): 130-135.
[6] 陈雄林, 曹小明, 张杰, 等. 细胞因子在糖尿病足发病机制中的作用及相关信号通路的研究进展[J]. 中国细胞生物学学报, 2025, 47(4): 975-980.
[7] 张梦丹, 朱凌燕, 刘玉. 糖尿病性下肢血管病变发病机制的研究进展[J]. 临床合理用药杂志, 2021, 14(6): 174-177.
[8] Yang, M., Liu, J., Zhou, X., Ding, H., Xu, J., Yang, B., et al. (2019) Correlation Analysis between Serum Vitamin D Levels and Lower Extremity Macrovascular Complications in Individuals with Type 2 Diabetes Mellitus. Journal of Diabetes Research, 2019, Article ID: 4251829. [Google Scholar] [CrossRef] [PubMed]
[9] Lin, C., Armstrong, D.G., Lin, C., Liu, P., Hung, S., Lee, S., et al. (2019) Nationwide Trends in the Epidemiology of Diabetic Foot Complications and Lower-Extremity Amputation over an 8-Year Period. BMJ Open Diabetes Research & Care, 7, e000795. [Google Scholar] [CrossRef] [PubMed]
[10] Hussain, M.A., Al-Omran, M., Salata, K., Sivaswamy, A., Forbes, T.L., Sattar, N., et al. (2019) Population-Based Secular Trends in Lower-Extremity Amputation for Diabetes and Peripheral Artery Disease. Canadian Medical Association Journal, 191, E955-E961. [Google Scholar] [CrossRef] [PubMed]
[11] Nativel, M., Potier, L., Alexandre, L., Baillet-Blanco, L., Ducasse, E., Velho, G., et al. (2018) Lower Extremity Arterial Disease in Patients with Diabetes: A Contemporary Narrative Review. Cardiovascular Diabetology, 17, Article ID: 138. [Google Scholar] [CrossRef] [PubMed]
[12] Hess, C.N., Norgren, L., Ansel, G.M., Capell, W.H., Fletcher, J.P., Fowkes, F.G.R., et al. (2017) A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease with a Focus on Revascularization. Circulation, 135, 2534-2555. [Google Scholar] [CrossRef] [PubMed]
[13] 白善姬. 浅析阿司匹林药理作用及不良反应[J]. 世界最新医学信息文摘, 2016, 16(15): 93.
[14] 黄晓晖, 刘雪姣, 周国华. 氯吡格雷个体化用药研究进展[J]. 医学研究生学报, 2019, 32(4): 443-448.
[15] 乔文豪, 王秀, 王佳丽, 等. 抗血小板药物药理作用和临床应用的研究进展[J]. 安徽医药, 2014, 18(9): 1621-1625.
[16] Bedenis, R., Stewart, M., Cleanthis, M., Robless, P., Mikhailidis, D.P. and Stansby, G. (2014) Cilostazol for intermittent claudication. Cochrane Database of Systematic Reviews, No. 10, CD003748. [Google Scholar] [CrossRef] [PubMed]
[17] de Donato, G., Setacci, F., Mele, M., Giannace, G., Galzerano, G. and Setacci, C. (2017) Restenosis after Coronary and Peripheral Intervention: Efficacy and Clinical Impact of Cilostazol. Annals of Vascular Surgery, 41, 300-307. [Google Scholar] [CrossRef] [PubMed]
[18] 张词侠, 张桂林, 李志勇, 等. 己酮可可碱的药理特性和治疗用途的研究进展[J]. 中国临床药理学杂志, 2008(1): 74-77.
[19] McCarty, M.F., O’Keefe, J.H. and DiNicolantonio, J.J. (2016) Pentoxifylline for Vascular Health: A Brief Review of the Literature. Open Heart, 3, e000365. [Google Scholar] [CrossRef] [PubMed]
[20] 季顺东. 血栓形成机制及抗凝药物的药理特点[J]. 中国计划生育和妇产科, 2021, 13(3): 25-28.
[21] 张天娇, 陈潮, 陈倩倩, 等. 中药对华法林药动学及抗凝作用影响的研究进展[J]. 中成药, 2023, 45(2): 488-493.
[22] Anand, S.S., Bosch, J., Eikelboom, J.W., Connolly, S.J., Diaz, R., Widimsky, P., et al. (2018) Rivaroxaban with or without Aspirin in Patients with Stable Peripheral or Carotid Artery Disease: An International, Randomised, Double-Blind, Placebo-Controlled Trial. The Lancet, 391, 219-229. [Google Scholar] [CrossRef] [PubMed]
[23] Govsyeyev, N., Nehler, M., Conte, M.S., Debus, S., Chung, J., Dorigo, W., et al. (2023) Rivaroxaban in Patients with Symptomatic Peripheral Artery Disease after Lower Extremity Bypass Surgery with Venous and Prosthetic Conduits. Journal of Vascular Surgery, 77, 1107-1118.e2. [Google Scholar] [CrossRef] [PubMed]
[24] Kavanagh, C.M., Heidenreich, M.J., Albright, J.J. and Aziz, A. (2016) Hybrid External Iliac Selective Endarterectomy Surgical Technique and Outcomes. Journal of Vascular Surgery, 64, 1327-1334. [Google Scholar] [CrossRef] [PubMed]
[25] 蔡冠军, 谭最. 动脉内膜剥脱术治疗下肢缺血性疾病的临床效果[J]. 世界最新医学信息文摘, 2016, 16(94): 257.
[26] 王晓, 崔世军, 谷涌泉, 等. 经皮腔内血管成形术与单纯药物治疗膝下动脉缺血临床疗效对比研究[J]. 中华老年心脑血管病杂志, 2018, 20(5): 458-461.
[27] 张温温, 孙灿龙. 经皮腔内支架成形术和动脉内膜剥脱术治疗下肢动脉硬化闭塞症的对比研究[J]. 临床医学, 2022, 42(2): 18-20.
[28] 刘海涛, 孙浩淼. 下肢动脉硬化闭塞症患者经皮腔内血管成形术治疗后再狭窄的影响因素[J]. 河南外科学杂志, 2025, 31(2): 149-152.
[29] Byrne, R.A., Joner, M., Alfonso, F. and Kastrati, A. (2013) Drug-Coated Balloon Therapy in Coronary and Peripheral Artery Disease. Nature Reviews Cardiology, 11, 13-23. [Google Scholar] [CrossRef] [PubMed]
[30] Giacoppo, D., Cassese, S., Harada, Y., Colleran, R., Michel, J., Fusaro, M., et al. (2016) Drug-Coated Balloon versus Plain Balloon Angioplasty for the Treatment of Femoropopliteal Artery Disease: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials. JACC: Cardiovascular Interventions, 9, 1731-1742. [Google Scholar] [CrossRef] [PubMed]
[31] 胡灵, 赵晓旭, 李玉姣. 药物涂层球囊在老年下肢动脉硬化闭塞症患者治疗中的疗效观察及其对血管内皮功能的影响[J]. 中国医学工程, 2023, 31(2): 113-116.
[32] Katsanos, K., Spiliopoulos, S., Reppas, L. and Karnabatidis, D. (2017) Debulking Atherectomy in the Peripheral Arteries: Is There a Role and What Is the Evidence? CardioVascular and Interventional Radiology, 40, 964-977. [Google Scholar] [CrossRef] [PubMed]
[33] 李梓伦, 吴伟滨, 王冕, 等. 定向斑块旋切系统在股腘动脉支架内再狭窄治疗中的应用效果[J]. 血管与腔内血管外科杂志, 2022, 8(3): 263-267, 283.
[34] 张传奇, 许斌. 脱疽病病因病机理论框架结构研究[J]. 浙江中医药大学学报, 2017, 41(10): 800-802, 805.
[35] 赵泽阳, 杨宇峰, 石岩. 糖尿病高危足中医病因病机及内治法探析[J]. 辽宁中医药大学学报, 2021, 23(3): 143-146.
[36] 张伟胜, 贾文魁, 郭志芹, 等. 贾文魁从肾虚血瘀角度治疗糖尿病下肢血管病变经验[J]. 中医药临床杂志, 2023, 35(10): 1928-1931.
[37] 石礼静. 基于中医传承辅助平台探讨吴深涛教授治疗糖尿病性下肢血管病变的用药规律及临证经验[D]: [硕士学位论文]. 天津: 天津中医药大学, 2022.
[38] 李萌, 徐强, 张朝晖. 张朝晖教授从脾胃论治糖尿病下肢血管病变经验简介[J]. 内蒙古中医药, 2018, 37(9): 32-34.
[39] 李品川, 张朝晖, 马静, 等. 湿痰瘀分型治疗糖尿病下肢血管病变[J]. 陕西中医, 2013, 34(2): 203-204.
[40] 周煜敏, 王明强. 基于“甘守津还”理论探讨糖尿病下肢血管病变的辨治[J]. 中医临床研究, 2025, 17(13): 41-45.
[41] 贾琳, 申小娜, 田琳. 黄芪桂枝五物汤加减对2型糖尿病下肢血管病变患者踝肱指数血流动力学的影响[J]. 中国药物与临床, 2024, 24(22): 1435-1438.
[42] 孟繁烨, 陈胜男, 谢敏, 等. 当归四逆汤治疗糖尿病下肢血管病变临床观察[J]. 四川中医, 2023, 41(12): 138-139.
[43] 施森, 刘勇, 曾宏, 等. 顾步汤加减改善2型糖尿病下肢动脉粥样硬化病变热毒伤阴、瘀阻脉络证患者血管内皮功能及对血流动力学的影响[J]. 中国中医基础医学杂志, 2021, 27(10): 1627-1630.
[44] 李汉生, 鲁德甫, 张娟. 血府逐瘀汤联合阿托伐他汀治疗2型糖尿病下肢血管病变临床疗效[J]. 湖北中医药大学学报, 2022, 24(3): 67-69.
[45] 王春辉, 常乐, 孟楠, 等. 中药黄芪的药理作用及临床应用效果观察[J]. 中医临床研究, 2018, 10(35): 104-107.
[46] 李昕统, 徐明月, 高丽君, 等. 黄芪当归药对治疗糖尿病下肢血管病变研究进展[J]. 山东中医杂志, 2021, 40(7): 774-777.
[47] 段峻青. 黄芪通脉汤辅助治疗2型糖尿病下肢动脉病变及对炎性因子和血管内皮功能的影响[J]. 陕西中医, 2016, 37(10): 1377-1379.
[48] 朱旭, 王新蕊, 文毅, 等. 黄芪葛根汤治疗糖尿病及其并发症的研究进展[J]. 中草药, 2025, 56(15): 5699-5708.
[49] 周书敏, 朱美蓉, 冯晓丹. 黄芪治疗糖尿病的临床进展[J]. 现代医学与健康研究电子杂志, 2024, 8(17): 130-133.
[50] 黄运超, 王益琼, 张婷, 等. 西红花酸通过抗炎促血管新生改善糖尿病下肢缺血作用研究[J]. 中国临床药理学与治疗学, 2025, 30(7): 899-906.
[51] 王景, 于洋, 张海丽, 等. 足三里穴位注射银杏叶提取物对糖尿病周围血管病变患者下肢动脉血流、血液流变学及血管新生指标的影响[J]. 中国医药导报, 2020, 17(18): 81-86.
[52] 黎传宝, 万兴富, 符关浩. 川芎嗪穴位注射治疗糖尿病下肢动脉病变疗效观察[J]. 现代中西医结合杂志, 2018, 27(28): 3135-3138.
[53] 徐文琦. 针刺夹脊穴干预脱疽静息痛的临床研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2017.
[54] 罗星子. 温和灸背俞穴治疗2型糖尿病下肢血管病变临床观察[D]: [硕士学位论文]. 合肥: 安徽中医药大学, 2021.
[55] 石光煜, 于国强, 张雪松, 等. 腹针联合大黄蛰虫丸治疗糖尿病下肢动脉硬化闭塞症的疗效观察[J]. 上海针灸杂志, 2021, 40(12): 1465-1469.
[56] 朱星, 靳宏光, 黄永生. 动脉粥样硬化的中医诊治研究概况[J]. 中国中医基础医学杂志, 2019, 25(8): 1164-1167.
[57] 庞晓英, 孙志. 针灸改善胰岛β细胞功能研究进展[J]. 针灸临床杂志, 2014, 30(4): 75-77.
[58] 周玲, 郑晓佳, 陈玲, 等. 中药熏洗治疗瘀血阻络型糖尿病下肢血管病变临床研究[J]. 新中医, 2025, 57(8): 70-75.
[59] 冯菲, 王文平, 宋玲玉, 等. 中药泡洗联合耳穴贴压治疗对糖尿病下肢血管病变患者症状及疗效的影响[C]//重庆市健康促进与健康教育学会. 临床医学健康与传播学术研讨会论文集(第一册). 2025: 75-78.