基于“气血互根”理论与线粒体自噬探讨慢性心力衰竭的病机及其中医药治疗
Exploring the Pathogenesis and Traditional Chinese Medicine Therapy of Chronic Heart Failure Based on the Theory of “Interdependence of Qi and Blood” and Mitophagy
DOI: 10.12677/acm.2025.15123422, PDF,   
作者: 辛世龙：黑龙江中医药大学研究生院，黑龙江 哈尔滨；客 蕊*：黑龙江中医药大学附属第一医院老年病科，黑龙江 哈尔滨
关键词: 慢性心力衰竭；线粒体自噬；气血互根；心肺气虚；气虚血瘀；Chronic Heart Failure； Mitophagy； Interdependence of Qi and Blood； Heart and Lung Qi Deficiency； Qi Deficiency and Blood Stasis
摘要: 慢性心力衰竭是各种心血管疾病的终末期表现，严重威胁人类健康。线粒体自噬作为细胞质量控制的重要机制，在慢性心衰发病过程中的作用不可忽视。本文系统综述了线粒体自噬在慢性心衰发生发展中的分子机制，并探讨了中医“气血互根”理论与线粒体自噬的联系。通过分析相关文献，本文发现线粒体自噬异常是导致心肌细胞能量代谢障碍、氧化应激损伤和细胞凋亡的关键因素，而这些病理过程与中医“气血互根、气虚血瘀”的病机高度契合。同时，“气血互根”理论中气血相互转化、相互依存的关系与线粒体自噬调控能量代谢的功能有内在联系。本文旨在为慢性心衰的治疗提供新的理论基础和研究思路。
Abstract: Chronic heart failure (CHF) represents the terminal stage of various cardiovascular diseases and poses a severe threat to human health. Mitophagy, as a critical cellular quality control mechanism, plays an indispensable role in the pathogenesis of CHF. This study systematically reviews the molecular mechanisms of mitophagy in the development and progression of chronic heart failure and explores the connection between the Traditional Chinese Medicine (TCM) theory of “interdependence of qi and blood” and mitophagy. Through analysis of relevant literature, we identify that dysregulated mitophagy is a key factor leading to impaired myocardial cell energy metabolism, oxidative stress damage, and apoptosis. These pathological processes are highly consistent with the TCM pathogenic mechanism of “qi deficiency and blood stasis” under the “interdependence of qi and blood” theory. Furthermore, the mutual transformation and interdependence of qi and blood in TCM theory exhibit intrinsic correlation with the mitophagy-regulated energy metabolism function. This study aims to provide new theoretical foundations and research directions for the treatment of chronic heart failure.
文章引用：辛世龙, 客蕊. 基于“气血互根”理论与线粒体自噬探讨慢性心力衰竭的病机及其中医药治疗[J]. 临床医学进展, 2025, 15(12): 379-385. https://doi.org/10.12677/acm.2025.15123422

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