NT-100校正眼压公式的临床验证研究

Clinical Validation of the Corrected Intraocular Pressure Formula for the NT-100

摘要: 目的：比较屈光手术后全自动智能非接触式眼压计(Auto-NCT, NT-100)内置校正眼压公式适用情况。方法：前瞻性研究，收集2024年8月~2024年11月在重庆眼视光眼科医院屈光手术科行角膜激光手术的患者31例(59眼)，其中行全飞秒手术者(small-incision lenticule extraction, SMILE) 8例(16眼)，行半飞秒手术者(laser in situ keratomileusis, LASIK) 23例(43眼)。获取术前及术后1月NT-100和角膜生物力学分析仪(corneal visualization scheimpflug technology, Corvis-ST)测得眼压值，联合Pentacam眼前节分析仪和NT-100得出5种校正眼压结果。应用独立样本t检验比较术前术后5种校正眼压值与Corvis-ST测得生物力学校正眼压(bIOP)，采用配对样本t检验比较术前术后校正眼压值。结果：本次共收集31例(59眼)患者，术前及术后Ehler校正眼压值、Orssengo/Pye校正眼压值和Kohlhaas校正眼压值及Auto-NCT、bIOP、IOPc测量值的差异具有统计学意义(P均 < 0.01)，Shah校正眼压值和Dresden校正眼压值差异无统计学意义(P > 0.05)，其中Shah校正眼压值差异最小。术前术后bIOP变化较小(1.23 ± 1.96 mmHg)，术前bIOP与5种校正眼压值存在显著差异(P < 0.001)，术后bIOP与Shah校正眼压值无明显差异(P > 0.05)，而与另外4种校正眼压值有显著差异(P < 0.001)。结论：针对中低度近视行板层角膜屈光术后患者，在NT-100内置5种校正眼压公式中，Shah公式相对可靠，对临床医师准确获得屈光术后眼压以及术后用药有一定的指导意义。

Abstract: Objective: To compare the application of the built-in corrected intraocular pressure formula of the fully automatic intelligent non-contact tonometer (Auto-NCT, NT-100) after refractive surgery. Methods: A prospective study was conducted to collect 31 cases (59 eyes) of patients who underwent corneal laser surgery in the refractive surgery department of Chongqing Ophthalmology Hospital from August 2024 to November 2024, of which 8 cases (16 eyes) underwent full-femtosecond (SMILE) surgery, 8 cases (16 eyes) underwent half-femtosecond (laser-in situ keratomileusis, SMILE) surgery, and 1 case (16 eyes) underwent half-femtosecond (laser-in situ keratomileusis, SMILE) surgery. Among them, 8 cases (16 eyes) underwent full femtosecond (SMILE) surgery and 23 cases (43 eyes) underwent laser in situ keratomileusis (LASIK) surgery. Preoperative and 1-month postoperative IOP values were obtained from NT-100 and corneal visualization scheimpflug technology (Corvis-ST), and five corrected IOP results were obtained by combining the Pentacam anterior segment analyzer and NT-100. An independent samples t-test was applied to compare the preoperative and postoperative values of the five corrected IOPs with the biomechanically corrected intraocular pressure (bIOP) measured by Corvis-ST, and a paired samples t-test was used to compare the preoperative and postoperative values of the corrected IOPs. Results: A total of 31 patients (59 eyes) were collected, and the differences between preoperative and postoperative Ehler-corrected IOP values, Orssengo/Pye-corrected IOP values and Kohlhaas-corrected IOP values, and Auto-NCT, bIOP, and IOPc measurements were statistically significant (all P < 0.01), and the differences between Shah-corrected and Dresden-corrected IOP values were not statistically significant (P > 0.05), and the difference in Shah-corrected IOP values was the smallest. The preoperative and postoperative bIOP changes were small (1.23 ± 1.96 mmHg), with a significant difference between the preoperative bIOP and the five corrected IOP values (P < 0.001), and the postoperative bIOP was not significantly different from the Shah-corrected IOP values (P > 0.05), whereas it was significantly different from the other four corrected IOP values (P < 0.001). Conclusion: For patients undergoing lamellar corneal refractive surgery for low to moderate myopia, among the five built-in corrected IOP formulas in NT-100, the Shah formula is relatively reliable, and it is of some significance in guiding clinicians to accurately obtain the post-refractive IOP as well as postoperative medication.