血液五元素铜、锌、钙、镁、铁与结直肠癌生物学行为关系的分析

Relationship Analysis of Blood Elements Cu, Zn, Ca, Mg, Fe and Colorectal Cancer Biological Behavior

摘要: 目的：了解血液中五种元素铜(Cu)、锌(Zn)、钙(Ca)、镁(Mg)、铁(Fe)在结直肠癌生物学行为中的变化规律，分析其变化规律与结直肠癌组织分化程度、脉管侵犯、TNM分期、淋巴结转移、远处转移等的关系，同时比较五元素在结直肠癌患者与健康人群中的变化规律，为结直肠癌诊断及判断预后提供一种新的思路。方法：采用五元素分析仪，对50例结直肠癌患者和20例健康对照者的血液样本进行五元素检测。对数据采用SPSS 27.0软件进行数据的统计分析。结果：1) 血液Cu、Zn、Ca、Fe含量为：健康对照组 > 结直肠癌非远处转移组 > 结直肠癌远处转移组；2) Cu、Fe在男性结直肠癌非远处转移组高于远处转移组；3) 血液Cu含量为：30~49岁 < 50~69岁 < 70~84岁，血液Fe含量：30~49岁 > 50~69岁 > 70~84岁；4) Fe在有淋巴结转移结直肠癌组低于无淋巴结转移组；5) 结直肠癌：TNM I期至III期血液Fe呈逐渐下降，I期患者Cu水平低于III、IV期患者，II期患者Mg、Fe低于IV期患者。

Abstract: Objective: To understand the changing patterns of five elements Cu, Zn, Ca, Mg, and Fe in the blood in the biological behavior of colorectal cancer, and to analyze the relationship between the changing patterns and the degree of colorectal cancer tissue differentiation, vascular invasion, TNM stage, lymph node metastasis, and distant metastasis. At the same time, to compare the changing patterns of the five elements in colorectal cancer patients and healthy people, and to provide a new idea for the diagnosis and prognosis of colorectal cancer. Methods: Five elements were detected in blood samples of 50 colorectal cancer patients and 20 healthy controls using a five-element analyzer. SPSS 27.0 software was used for statistical analysis of the data. Results: 1) The blood Cu, Zn, Ca and Fe contents were as follows: healthy control group > colorectal cancer non-distant metastasis group > colorectal cancer distant metastasis group; 2) Cu and Fe in male colorectal cancer non-distant metastasis group were higher than those in distant metastasis group; 3) Blood Cu content was as follows: 30~49 years old < 50~69 years old < 70~84 years old; blood Fe content was as follows: 30~49 years old > 50~69 years old > 70~84 years old; 4) Fe in colorectal cancer group with lymph node metastasis was lower than that in group without lymph node metastasis; 5) Blood Fe decreased gradually from TNM stage I to stage III of colorectal cancer. The Cu level of patients in stage I was lower than that of patients in stages III and IV, and the Mg and Fe level of patients in stage II were lower than those in stage IV.