艾瑞昔布联合玻璃酸钠治疗膝骨关节炎的疗效及其对患者炎性反应的影响

The Efficacy of Celecoxib Combined with Sodium Hyaluronate in the Treatment of Knee Osteoarthritis and Its Impact on Patients’ Inflammatory Response

摘要: 目的：分析针对膝骨关节炎(KOA)患者，联合应用艾瑞昔布、玻璃酸钠治疗对改善其炎症因子的价值。方法：收集2025.01~2025.10于本院就诊的KOA患者70例。简单随机化法分设组别，参比组(玻璃酸钠治疗，n = 35)，分析组(玻璃酸钠 + 艾瑞昔布治疗，n = 35)。汇总反馈数据。结果：分析组干预后炎性因子水平较参比组显著降低，且疼痛感知也显著降低，P < 0.05。分析组干预后在HSS评分各维度上分值均高于参比组，P < 0.05。分析组干预后不良反应发生率均显著低于参比组，P < 0.05。结论：针对KOA患者，联合应用艾瑞昔布与玻璃酸钠治疗，可有效减轻其炎症因子水平，并降低其对疼痛的感知，还可改善其膝关节功能，降低并发症发生率，应用价值高。

Abstract: Objective: to analyze the value of the combined application of irecoxib and sodium hyaluronate in improving inflammatory factors in patients with knee osteoarthritis. Methods: 70 patients with knee osteoarthritis were selected from January 2025 to October 2025 in our hospital. The simple randomization method was divided into the reference group (sodium hyaluronate treatment, n = 35) and the analysis group (sodium hyaluronate + irecoxib treatment, n = 35). Summarize the feedback data. Results: after the intervention, the levels of inflammatory factors in the analysis group were significantly lower than those in the reference group, and the pain perception was also significantly lower, P < 0.05. After the intervention, the score of HSS score in the analysis group was higher than that in the reference group, P < 0.05. The incidence of adverse reactions after the intervention in the analysis group was significantly lower than that in the reference group, P < 0.05. Conclusion: for patients with knee osteoarthritis, the combined application of irecoxib and sodium hyaluronate can effectively reduce the level of inflammatory factors, reduce their perception of pain, improve their knee function, reduce the incidence of complications, and has high application value.