相关信号通路下桂枝芍药知母汤治疗类风湿关节炎研究进展

Research Progress of Guizhi Shaoyao Zhimu Decoction in the Treatment of Rheumatoid Arthritis Based on Related Signaling Pathways

摘要: 类风湿关节炎(rheumatoid arthritis, RA)是一种自身免疫性疾病。主要病理特征包括滑膜炎、炎症细胞浸润以及骨组织损伤等。临床上常见症状为对称性的多关节疼痛，严重情况下可能导致关节畸形、关节功能下降甚至残疾。虽然RA的发病机制仍然不够清楚，但大量临床观察和动物实验的证据都表明，炎症与其发病及进展有着密切关系。提示抑制炎症反应或许是类风湿关节炎治疗的关键方向。桂枝芍药知母汤(Guizhi Shaoyao Zhimu Decoction, GSZD)为治疗RA经典方剂，通过检索近20年有关桂枝芍药知母汤治疗RA的文献资料，作者如PubMed、WOSCC、CNKI、Wanfang、VIP，以综述其炎症通路方面，为进一步研究桂枝芍药知母汤联合靶向治疗提供了强有力的支持。概述其调控RA相关炎性信号通路的最新研究进展，以理论指导桂枝白芍知母汤靶向治疗。

Abstract: Rheumatoid arthritis (RA) is an autoimmune disease. Its main pathological features include synovitis, inflammatory cell infiltration, and bone tissue damage. Common clinical symptoms are symmetrical polyarthritis pain. In severe cases, it may lead to joint deformity, decreased joint function, and even disability. Although the pathogenesis of RA is still not fully understood, a large amount of clinical observations and animal experiments have shown that inflammation is closely related to its onset and progression. This suggests that inhibiting the inflammatory response may be a key direction for the treatment of RA. Guizhi Shaoyao Zhimu Decoction (GSZD) is a classic prescription for treating RA. By searching for literature on GSZD for RA treatment in the past 20 years in databases such as PubMed, WOSCC, CNKI, Wanfang, and VIP, this paper reviews its inflammatory pathways, providing strong support for further research on the combination of GSZD and targeted therapy. It summarizes the latest research progress on the regulation of RA-related inflammatory signaling pathways by GSZD, providing theoretical guidance for targeted therapy with GSZD.