离心联合精滤板过滤技术用于提高藿香正气合剂的稳定性

Centrifugation Combined with Fine Filter Plate Filtration Technology Is Used to Improve the Stability of Huoxiang Zhengqi Mixture

摘要: 目的：优化藿香正气合剂的生产工艺，提高药物的稳定性。方法：以药液浊度、橙皮苷含量作为评价指标，通过考察滤膜过滤、滤芯过滤、纸板过滤、高速离心等不同方式处理药液的性状及稳定性，进行比较分析，筛选出最佳的制剂工艺。结果：将藿香正气合剂药液通过管式离心机高速离心处理后，经精滤板过滤可制备出药液澄明度佳、稳定性良好的藿香正气合剂药液。结论：新工艺稳定可行。该结果可指导口服液体制剂提高产品稳定性。

Abstract: Objective: To optimize the production technology of Huoxiang Zhengqi mixture and improve the stability of the drug. Methods: Taking the turbidity and hesperidin content of the liquid medicine as evaluation indices, the properties and stability of the liquid medicine treated by different methods, such as membrane filtration, filter element filtration, cardboard filtration and high-speed centrifugation, were compared and analyzed, and the best preparation technology was selected. Results: The Huoxiang Zhengqi mixture liquid medicine with good clarity and stability can be prepared by high-speed centrifugal treatment with a tube centrifuge and filtration with a fine filter plate. Conclusion: The new technology is stable and feasible. The results can guide oral liquid preparation to improve product stability.