阿立哌唑治疗精神分裂症的血药浓度及疗效差异化研讨

Discussion on the Blood Drug Concentration and Efficacy Variations of Aripiprazole in the Treatment of Schizophrenia

摘要: 目的：探究阿立哌唑治疗精神分裂症患者不同时间段血药浓度数值、疗效的差异。方法：2024年5月~2025年3月在本院精神科的患者选取了86名精神分裂症患者，用阿立哌唑做为期8周的不固定剂量治疗，应用反向高效液相色谱技术(RP-HPLC)对治疗2、4、8周末的血药浓度测定，分析血药浓度与药物剂量、疗效相关性。结果：入组患者治疗第2、4、8周末血药浓度数值差异化显著(P < 0.05)。血药浓度与药物剂量呈显著正相关(r = 0.788, P < 0.01)；第2、4、8周末血药浓度与PANSS减分率呈显著正相关(r = 0.520、0.635、0.682，P均<0.05)；有效组患者第4、8周末血药浓度显著高于无效组(P < 0.01)。结果：阿立哌唑治疗精神分裂症的血药浓度越高，则临床疗效越好。

Abstract: Objective: To investigate the differences in blood drug concentration and efficacy of aripiprazole in patients with schizophrenia across different time periods. Methods: From May 2024 to March 2025, 86 schizophrenia patients were selected from the psychiatric department of our hospital. They received 8 weeks of fixed-dose aripiprazole treatment, and blood drug concentrations were measured at the end of weeks 2, 4, and 8 using reverse-phase high-performance liquid chromatography (RP-HPLC). The correlations between blood drug concentration, medication dosage, and efficacy were analyzed. Results: The blood drug concentration values at the end of weeks 2, 4, and 8 showed significant differences (P < 0.05). Blood drug concentration was significantly positively correlated with medication dosage (r = 0.788, P < 0.01). At the end of weeks 2, 4, and 8, blood drug concentration was also significantly positively correlated with the PANSS reduction rate (r = 0.520, 0.635, 0.682, all P < 0.05). The blood drug concentration at the end of weeks 4 and 8 was significantly higher in the effective group than in the ineffective group (P < 0.01). Conclusion: Higher blood drug concentration of aripiprazole in the treatment of schizophrenia correlates with better clinical efficacy.