氧化苦参碱治疗带状疱疹后神经痛的临床疗效

Clinical Efficacy of Oxymatrine in the Treatment of Postherpetic Neuralgia

摘要: 目的：比较普瑞巴林和氧化苦参碱在带状疱疹后神经痛患者中的临床疗效和安全性。方法：研究对象为40例带状疱疹后神经痛患者。根据数字表法随机分为普瑞巴林胶囊组(对照组)和氧化苦参碱组(观察组)，每组各20例患者。治疗周期为2周。采用视觉模拟评分(VAS)评估两组患者治疗前后疼痛严重程度；采用睡眠质量量表(SQS)和匹兹堡睡眠质量指数(PSQI)来评估两组患者治疗前后睡眠质量；采用焦虑/抑郁自评量表(SAS/SDS)评估两组患者治疗前后的焦虑和抑郁。结果：与治疗前相比，治疗后两组患者VAS评分均降低(所有P < 0.05)，而且观察组评分低于对照组(P < 0.05)；治疗后两组患者SQS和PSQI评分均降低(所有P < 0.05)，而且观察组评分低于对照组(P < 0.05)；治疗后两组患者SAS和SDS评分均降低(所有P < 0.05)，而且观察组评分低于对照组(P < 0.05)。此外，与对照组相比，观察组患者疼痛缓解时间更短(P < 0.05)。两组患者不良反应发生率无统计学差异。结论：氧化苦参碱是一种有效且安全的治疗带状疱疹后神经痛的药物，可以改善镇痛效果和睡眠质量，缓解负面情绪。

Abstract: Objective: To compare the clinical efficacy and safety of pregabalin and oxymatrine in patients with postherpetic neuralgia. Methods: The research subjects are 40 patients with postherpetic neuralgia. According to the numerical table method, patients were randomly divided into a pregabalin capsule group (control group) and oxymatrine group (observation group), with 20 patients in each group. The treatment cycle was 2 weeks. Visual Analog Scale (VAS) was used to evaluate the severity of pain in two groups of patients before and after treatment; The Sleep Quality Scale (SQS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the sleep quality of two groups of patients before and after treatment; The Self Rating Anxiety/Depression Scale (SAS/SDS) was used to evaluate the anxiety and depression of two groups of patients before and after treatment. Results: Compared with before treatment, the VAS scores of both groups of patients decreased after treatment (all P < 0.05), and the observation group had lower scores than the control group (P < 0.05); After treatment, the SQS and PSQI scores of both groups of patients decreased (all P < 0.05), and the observation group had lower scores than the control group (P < 0.05); After treatment, the SAS and SDS scores of both groups of patients decreased (all P < 0.05), and the observation group had lower scores than the control group (P < 0.05). In addition, compared with the control group, the observation group had a shorter pain relief time (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients. Conclusion: Oxymatrine was an effective and safe medication for treating postherpetic neuralgia, which could improve analgesic effects, sleep quality, and alleviate negative emotions.