“破瘀消癥杀胚方”联合米非司酮与甲氨蝶呤治疗输卵管妊娠的临床疗效

The Clinical Efficacy of the “Breaking Blood Stasis, Eliminating Symptoms and Killing Embryos Formula” Combined with Mifepristone and Methotrexate in the Treatment of Tubal Pregnancy

摘要: 目的：探讨破瘀消癥杀胚方联合米非司酮与甲氨蝶呤治疗输卵管妊娠的临床疗效。方法：选择2024年8月至2025年10月我院收治的宫外孕患者66例，按照随机分组的方式分为对照组和观察组，对照组实施保守治疗，观察组采取破瘀消癥杀胚方联合米非司酮与甲氨蝶呤治疗。探讨不同治疗方式对患者的临床效果。结果：观察组患者治疗后的腹痛、阴道出血、下腹包块等主要症状及腰酸、乏力、肛门坠胀等次要症状的中医症候积分均低于对照组(P < 0.05)。观察组的腹痛消失时间、包块消失时间、阴道出血持续时间均低于对照组(P < 0.05)。观察组不良反应发生率低于对照组(P < 0.05)。结论：破瘀消癥杀胚方联合米非司酮与甲氨蝶呤治疗输卵管妊娠能有效降低患者中医症候积分，缩短症状消失时间，临床疗效显著，值得推广。

Abstract: Objective: To explore the clinical efficacy of the prescription for Breaking Blood Stasis, Eliminating Symptoms and Killing Embryos combined with mifepristone and methotrexate in the treatment of tubal pregnancy. Methods: A total of 66 patients with ectopic pregnancy admitted to our hospital from August 2024 to October 2025 were selected and randomly divided into a control group and an observation group. The control group received conservative treatment, while the observation group was treated with the “Breaking Blood Stasis, Eliminating Symptoms and Killing Embryos Formula” combined with mifepristone and methotrexate, to explore the clinical effects of different treatment methods on patients. Result: The TCM syndrome scores of the main symptoms such as abdominal pain, vaginal bleeding, and lower abdominal mass, as well as the secondary symptoms such as lumbago, fatigue, and anal distension in the observation group after treatment were all lower than those in the control group (P < 0.05). The disappearance time of abdominal pain, the disappearance time of mass and the duration of vaginal bleeding in the observation group were all lower than those in the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). Conclusion: The combination of the “Breaking Blood Stasis, Eliminating Symptoms and Killing Embryos” formula with mifepristone and methotrexate in the treatment of tubal pregnancy can effectively reduce the TCM syndrome score of patients, shorten the time for symptom disappearance, and has significant clinical efficacy, which is worthy of promotion.